LIPID MAPS

LMPD ID

LMP003227

Gene ID

168391

Species

Homo sapiens (Human)

Gene Name

polypeptide N-acetylgalactosaminyltransferase-like 5

Gene Symbol

GALNTL5

Synonyms

GALNACT19; GALNT15; GalNAc-T5L

Alternate Names

inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; galNAc-T15; pp-GaNTase 15; polypeptide GalNAc transferase 15; polypeptide GalNAc transferase-like 5; protein-UDP acetylgalactosaminyltransferase 15; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15; putative polypeptide N-acetylgalactosaminyltransferase-like protein 5; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5

Chromosome

7

Map Location

7q36.1

inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
Refseq ID	NP_660335
Protein GI	281485547
UniProt ID	Q7Z4T8
mRNA ID	NM_145292
Length	443
RefSeq Status	VALIDATED
MRNAIIQGLFYGSLTFGIWTALLFIYLHHNHVSSWQKKSQEPLSAWSPGKKVHQQIIYGSEQIPKPHVIVKRTDEDKAKSMLGTDFNHTNPELHKELLKYGFNVIISRSLGIEREVPDTRSKMCLQKHYPARLPTASIVICFYNEECNALFQTMSSVTNLTPHYFLEEIILVDDMSKVDDLKEKLDYHLETFRGKVKIIRNKKREGLIRARLIGASHASGDVLVFLDSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLEYKPSPLVRGTFDWNLQFKWDNVFSYEMDGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQLFIIPCSRVGHISKKQTGKPSTIISAMTHNYLRLVHVWLDEYKEQFFLRKPGLKYVTYGNIRERVELRKRLGCKSFQWYLDNVFPELEASVNSL

Entrez Gene ID

168391

Gene Name

polypeptide N-acetylgalactosaminyltransferase-like 5

Gene Symbol

GALNTL5

Species

Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005768	IEA:UniProtKB-KW	C	endosome
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0007286	IMP:UniProtKB	P	spermatid development

KEGG Pathway Links

KEGG Pathway ID	Description
hsa00512	Mucin type O-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_200727	O-linked glycosylation
REACT_115606	O-linked glycosylation of mucins

InterPro Annotations

Accession	Description
IPR001173	Glycosyltransferase 2-like
IPR029044	Nucleotide-diphospho-sugar transferases

Entry Information

Gene Name

polypeptide N-acetylgalactosaminyltransferase-like 5

Protein Entry

GLTL5_HUMAN

UniProt ID

Q7Z4T8

Species

Human

Comments

Comment Type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z4T8-1; Sequence=Displayed; Name=2; IsoId=Q7Z4T8-2; Sequence=VSP_011227, VSP_011228; Note=No experimental confirmation available.;
Caution	In contrast to other members of the family, lacks the C- terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. No glycosyltransferase activity has been detected in an in vitro assay (PubMed:24398516).
Cofactor	Name=Mn(2+); Xref=ChEBI
Disease	Note=Defects in GALNTL5 have been found in a patient with primary infertility due to asthenozoospermia.
Domain	There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
Function	Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.
Sequence Caution	Sequence=AAM20912.1; Type=Frameshift; Positions=114, 122; Evidence= ; Sequence=AAP97318.1; Type=Frameshift; Positions=114, 122; Evidence= ;
Similarity	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Subcellular Location	Late endosome membrane ; Single-pass type II membrane protein . Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity).
Tissue Specificity	Mainly expressed in testis. Weakly or not expressed in other tissues.
Web Resource	Name=Functional Glycomics Gateway - GTase; Note=Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_498";
Web Resource	Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNTL5";

Unique RefSeq proteins for LMP003227 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
281485547	RefSeq	NP_660335	443	inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

Identical Sequences to LMP003227 proteins

Reference	Database	Accession	Length	Protein Name
GI:281485547	RefSeq	XP_006715925.1	443	PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase-like protein 5 isoform X1 [Homo sapiens]
GI:281485547	RefSeq	XP_006715926.1	443	PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase-like protein 5 isoform X2 [Homo sapiens]
GI:281485547	SwissProt	Q7Z4T8.3	443	RecName: Full=Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; AltName: Full=Polypeptide GalNAc transferase 15; Short=GalNAc-T15; Short=pp-GaNTase 15; AltName: Full=Protein-UDP acetylgalactosaminyltransferase 15; AltName: Full=UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15 [Homo sapiens]

Related Sequences to LMP003227 proteins

Reference	Database	Accession	Length	Protein Name
GI:281485547	EMBL	CBH30722.1	443	unnamed protein product [Homo sapiens]
GI:281485547	GenBank	AAH22021.1	443	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 [Homo sapiens]
GI:281485547	GenBank	EAL24517.1	443	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15 [Homo sapiens]
GI:281485547	GenBank	ABM84871.1	443	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5, partial [synthetic construct]
GI:281485547	GenBank	AHD79136.1	443	Sequence 28780 from patent US 8586006
GI:281485547	GenBank	AIC57915.1	443	GALNTL5, partial [synthetic construct]