Gene/Proteome Database (LMPD)

LMPD ID
LMP003230
Gene ID
71584
Species
Mus musculus (Mouse)
Gene Name
glycerophosphodiester phosphodiesterase domain containing 2
Gene Symbol
Gdpd2
Synonyms
9130017L10Rik; Gde3; Obdpf
Alternate Names
glycerophosphoinositol inositolphosphodiesterase GDPD2; glycerophosphodiester phosphodiesterase 3; osteoblast differentiation promoting factor; glycerophosphodiester phosphodiesterase domain-containing protein 2
Chromosome
X
Map Location
X|X C2
EC Number
3.1.4.43

Proteins

glycerophosphoinositol inositolphosphodiesterase GDPD2
Refseq ID NP_076097
Protein GI 12963749
UniProt ID Q9ESM6
mRNA ID NM_023608
Length 539
RefSeq Status VALIDATED
MADSPGCCSIWARCLHCLYSCHWRKYPKQKMQTSKCDCIWFGLLFLTFLLSLGWLYIGLILLNDLHNFNEFLFRHWGHWMDWSLIVLLVVSLLVTYASLLLLLGLLLQLCGQPLHLHSLHKVLLLLIVLLVAAGLVGLDIQWRQEWHSLRLSLQATAPFLHIGAVAGITLLAWPVADTFYRIHPRGPKVLLLLLFFGVTLVIYLMPLLFISSPCIMKLRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGAAVFETDVMVSSDGVPFLMHDERLSRTTNVASVFPERISAHSSDFSWAELQRLNAGTWFLERQPFWGAKKLSGSDRKEAENQTIPALEELLKEAAALNLSIMFDLRRPPRNHTYYDTFVNQTLEAVLSANVSQAMVLWLPDEDRANVQQRAPRMRQIYGHQGGNWTERPQFLNLPYQDLPALDIKALHQDNISVNLFVVNKPWLFSLLWCAGVDSVTTNACQLLQQMQNPLWLLPPQKYLMIWVITDCASILLLLSIFLLRGGCAKRNRTGLETAVLLTKINNFASE

Gene Information

Entrez Gene ID
71584
Gene Name
glycerophosphodiester phosphodiesterase domain containing 2
Gene Symbol
Gdpd2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008889 IEA:InterPro F glycerophosphodiester phosphodiesterase activity
GO:0047394 IEA:UniProtKB-EC F glycerophosphoinositol inositolphosphodiesterase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase domain containing 2
Protein Entry
GDPD2_MOUSE
UniProt ID
Q9ESM6
Species
Mouse

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=97.2 mM for glycerophosphoinositol {ECO:0000269|PubMed:19596859}; Vmax=1.9 nmol/min/mg enzyme {ECO:0000269|PubMed:19596859};
Catalytic Activity 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = glycerol + 1D-myo-inositol 1-phosphate.
Caution The catalytic domain of Gdpd2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected. {ECO:0000305}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Developmental Stage Up-regulated during osteoblast differentiation. Detected at low levels in mature osteoblasts.
Function Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:12933806, ECO:0000269|PubMed:19596859}.
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
Similarity Contains 1 GP-PDE domain. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12933806}; Multi-pass membrane protein {ECO:0000269|PubMed:12933806}. Cytoplasm {ECO:0000269|PubMed:12933806}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12933806}. Note=Colocalizes with the actin cytoskeleton.
Tissue Specificity Detected in spleen, femur and calvaria. {ECO:0000269|PubMed:12933806, ECO:0000269|PubMed:15276213}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003230 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12963749 RefSeq NP_076097 539 glycerophosphoinositol inositolphosphodiesterase GDPD2

Identical Sequences to LMP003230 proteins

Reference Database Accession Length Protein Name
GI:12963749 GenBank AAH38274.1 539 Glycerophosphodiester phosphodiesterase domain containing 2 [Mus musculus]
GI:12963749 GenBank ABH98219.1 539 Sequence 2 from patent US 7070946
GI:12963749 GenBank EDL14170.1 539 glycerophosphodiester phosphodiesterase domain containing 2, isoform CRA_b [Mus musculus]
GI:12963749 RefSeq XP_006528358.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Mus musculus]
GI:12963749 RefSeq XP_006528359.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2 [Mus musculus]
GI:12963749 SwissProt Q9ESM6.1 539 RecName: Full=Glycerophosphoinositol inositolphosphodiesterase GDPD2; AltName: Full=Glycerophosphodiester phosphodiesterase 3; AltName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 2; AltName: Full=Osteoblast differentiation promoting factor [Mus musculus]

Related Sequences to LMP003230 proteins

Reference Database Accession Length Protein Name
GI:12963749 GenBank EDL14169.1 604 glycerophosphodiester phosphodiesterase domain containing 2, isoform CRA_a, partial [Mus musculus]
GI:12963749 GenBank EDL95923.1 538 glycerophosphodiester phosphodiesterase domain containing 2 (predicted), isoform CRA_a [Rattus norvegicus]
GI:12963749 RefSeq NP_001100414.1 538 glycerophosphoinositol inositolphosphodiesterase GDPD2 [Rattus norvegicus]
GI:12963749 RefSeq XP_006257125.1 567 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2 [Rattus norvegicus]
GI:12963749 RefSeq XP_006257126.1 538 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Rattus norvegicus]
GI:12963749 RefSeq XP_006257127.1 538 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Rattus norvegicus]