Gene/Proteome Database (LMPD)

LMPD ID
LMP003239
Gene ID
56305
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol transfer protein, beta
Gene Symbol
Pitpnb
Synonyms
PI-TP-beta
Alternate Names
phosphatidylinositol transfer protein beta isoform; Pitp beta; ptdInsTP beta; ptdIns transfer protein beta; phosphotidylinositol transfer protein, beta
Chromosome
5
Map Location
5 F|5
Summary
This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded protein catalyzes the transfer of phospholipids (phosphatidylinositol and phosphatidylcholine) between membranes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Orthologs
View orthologs and multiple alignments for Pitpnb

Proteins

phosphatidylinositol transfer protein beta isoform isoform 1
Refseq ID NP_001288572
Protein GI 675294839
UniProt ID Q8JZZ5
mRNA ID NM_001301643
Length 272
RefSeq Status REVIEWED
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETLRSQGQVRGTSAACDD
phosphatidylinositol transfer protein beta isoform isoform 2
Refseq ID NP_062614
Protein GI 9790159
UniProt ID P53811
mRNA ID NM_019640
Length 271
RefSeq Status REVIEWED
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA
phosphatidylinositol transfer protein beta isoform isoform 3
Refseq ID NP_001288573
Protein GI 675294842
UniProt ID P53811
mRNA ID NM_001301644
Length 198
RefSeq Status REVIEWED
MIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA
phosphatidylinositol transfer protein beta isoform isoform 4
Refseq ID NP_001288595
Protein GI 675294851
UniProt ID Q8JZZ5
mRNA ID NM_001301666
Length 244
RefSeq Status REVIEWED
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENDYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETLRSQGQVRGTSAACDD

Gene Information

Entrez Gene ID
56305
Gene Name
phosphatidylinositol transfer protein, beta
Gene Symbol
Pitpnb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005543 ISA:MGI F phospholipid binding
GO:0001701 IMP:MGI P in utero embryonic development
GO:0006810 IEA:UniProtKB-KW P transport

REACTOME Pathway Links

REACTOME Pathway ID Description
5892983 Glycerophospholipid biosynthesis
5892760 Metabolism
5893988 PI Metabolism
5893987 PI and PC transport between ER and Golgi membranes

Domain Information

InterPro Annotations

Accession Description
IPR001666 Phosphatidylinositol transfer protein
IPR023393 START-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol transfer protein, beta
Protein Entry
Q8JZZ5_MOUSE
UniProt ID
Q8JZZ5
Species
Mouse

Comments

Comment Type Description
Function Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Ptm Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting. {ECO:0000269|PubMed:11953429}.
Similarity Belongs to the PtdIns transfer protein family. PI transfer class I subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm. Golgi apparatus.

Identical and Related Proteins

Unique RefSeq proteins for LMP003239 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
675294839 RefSeq NP_001288572 272 phosphatidylinositol transfer protein beta isoform isoform 1
9790159 RefSeq NP_062614 271 phosphatidylinositol transfer protein beta isoform isoform 2
675294842 RefSeq NP_001288573 198 phosphatidylinositol transfer protein beta isoform isoform 3
675294851 RefSeq NP_001288595 244 phosphatidylinositol transfer protein beta isoform isoform 4

Identical Sequences to LMP003239 proteins

Reference Database Accession Length Protein Name
GI:9790159 DBBJ BAC25830.1 271 unnamed protein product [Mus musculus]
GI:9790159 GenBank AAA87593.1 271 phosphatidylinositol transfer protein beta isoform [Mus musculus]
GI:9790159 GenBank ABK42307.1 271 PI-TP beta [synthetic construct]
GI:9790159 SwissProt P53811.2 271 RecName: Full=Phosphatidylinositol transfer protein beta isoform; Short=PI-TP-beta; Short=PtdIns transfer protein beta; Short=PtdInsTP beta [Mus musculus]

Related Sequences to LMP003239 proteins

Reference Database Accession Length Protein Name
GI:9790159 DBBJ BAA04669.1 271 phosphatidylinositol transfer protein [Rattus norvegicus]
GI:9790159 GenBank EDL19992.1 271 phosphatidylinositol transfer protein, beta [Mus musculus]
GI:9790159 PDB 2A1L 270 Chain A, Rat Pitp-Beta Complexed To Phosphatidylcholine
GI:9790159 RefSeq NP_446194.1 271 phosphatidylinositol transfer protein beta isoform [Rattus norvegicus]
GI:9790159 RefSeq XP_005344271.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X2 [Microtus ochrogaster]
GI:9790159 SwissProt P53812.2 271 RecName: Full=Phosphatidylinositol transfer protein beta isoform; Short=PI-TP-beta; Short=PtdIns transfer protein beta; Short=PtdInsTP beta [Rattus norvegicus]