Gene/Proteome Database (LMPD)

LMPD ID
LMP003334
Gene ID
11818
Species
Mus musculus (Mouse)
Gene Name
apolipoprotein H
Gene Symbol
Apoh
Synonyms
B2GPI; beta-2-GPI; beta2-GPI
Alternate Names
beta-2-glycoprotein 1; apo-H; beta(2)GPI; APC inhibitor; beta-2-glycoprotein I; activated protein C-binding protein
Chromosome
11
Map Location
11 D|11 71.8 cM

Proteins

beta-2-glycoprotein 1 precursor
Refseq ID NP_038503
Protein GI 160358825
UniProt ID Q01339
mRNA ID NM_013475
Length 345
RefSeq Status VALIDATED
MVSPVLALFSAFLCHVAIAGRICPKPDDLPFATVVPLKTSYDPGEQIVYSCKPGYVSRGGMRRFTCPLTGMWPINTLRCVPRVCPFAGILENGIVRYTSFEYPKNISFACNPGFFLNGTSSSKCTEEGKWSPDIPACARITCPPPPVPKFALLKDYRPSAGNNSLYQDTVVFKCLPHFAMIGNDTVMCTEQGNWTRLPECLEVKCPFPPRPENGYVNYPAKPVLLYKDKATFGCHETYKLDGPEEAECTKTGTWSFLPTCRESCKLPVKKATVLYQGMRVKIQEQFKNGMMHGDKIHFYCKNKEKKCSYTVEAHCRDGTIEIPSCFKEHSSLAFWKTDASELTPC
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1989 peptide sequence: MVSPVLALFSAFLCHVAIA mat_peptide: 20..345 product: beta-2-glycoprotein 1 calculated_mol_wt: 36648 peptide sequence: GRICPKPDDLPFATVVPLKTSYDPGEQIVYSCKPGYVSRGGMRRFTCPLTGMWPINTLRCVPRVCPFAGILENGIVRYTSFEYPKNISFACNPGFFLNGTSSSKCTEEGKWSPDIPACARITCPPPPVPKFALLKDYRPSAGNNSLYQDTVVFKCLPHFAMIGNDTVMCTEQGNWTRLPECLEVKCPFPPRPENGYVNYPAKPVLLYKDKATFGCHETYKLDGPEEAECTKTGTWSFLPTCRESCKLPVKKATVLYQGMRVKIQEQFKNGMMHGDKIHFYCKNKEKKCSYTVEAHCRDGTIEIPSCFKEHSSLAFWKTDASELTPC

Gene Information

Entrez Gene ID
11818
Gene Name
apolipoprotein H
Gene Symbol
Apoh
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IEA:Ensembl C cell surface
GO:0042627 IEA:Ensembl C chylomicron
GO:0031012 IEA:Ensembl C extracellular matrix
GO:0005615 IDA:MGI C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0034364 IEA:Ensembl C high-density lipoprotein particle
GO:0034361 IEA:Ensembl C very-low-density lipoprotein particle
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0060230 IEA:Ensembl F lipoprotein lipase activator activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0007597 IEA:Ensembl P blood coagulation, intrinsic pathway
GO:0016525 IEA:Ensembl P negative regulation of angiogenesis
GO:0030195 IEA:Ensembl P negative regulation of blood coagulation
GO:0010596 IEA:Ensembl P negative regulation of endothelial cell migration
GO:0001937 IEA:Ensembl P negative regulation of endothelial cell proliferation
GO:0051918 IEA:Ensembl P negative regulation of fibrinolysis
GO:0033033 IEA:Ensembl P negative regulation of myeloid cell apoptotic process
GO:0034392 IEA:Ensembl P negative regulation of smooth muscle cell apoptotic process
GO:0031639 IEA:Ensembl P plasminogen activation
GO:0051006 IEA:Ensembl P positive regulation of lipoprotein lipase activity
GO:0030193 IMP:MGI P regulation of blood coagulation
GO:0006641 IEA:Ensembl P triglyceride metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR015104 Beta-2-glycoprotein-1 fifth domain
IPR000436 Sushi/SCR/CCP domain

UniProt Annotations

Entry Information

Gene Name
apolipoprotein H
Protein Entry
APOH_MOUSE
UniProt ID
Q01339
Species
Mouse

Comments

Comment Type Description
Function Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Similarity Contains 4 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
Subcellular Location Secreted.
Tissue Specificity Expressed by the liver and secreted in plasma.

Identical and Related Proteins

Unique RefSeq proteins for LMP003334 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160358825 RefSeq NP_038503 345 beta-2-glycoprotein 1 precursor

Identical Sequences to LMP003334 proteins

Reference Database Accession Length Protein Name
GI:160358825 DBBJ BAA00945.1 345 beta-2-glycoprotein I [Mus musculus]
GI:160358825 EMBL CAA72190.1 345 apolipoprotein H [Mus musculus]
GI:160358825 GenBank AAH19811.1 345 Apolipoprotein H [Mus musculus]
GI:160358825 GenBank AAH53338.1 345 Apolipoprotein H [Mus musculus]
GI:160358825 GenBank EDL34341.1 345 apolipoprotein H [Mus musculus]
GI:160358825 SwissProt Q01339.1 345 RecName: Full=Beta-2-glycoprotein 1; AltName: Full=APC inhibitor; AltName: Full=Activated protein C-binding protein; AltName: Full=Apolipoprotein H; Short=Apo-H; AltName: Full=Beta-2-glycoprotein I; Short=B2GPI; Short=Beta(2)GPI; Flags: Precursor [Mus musculus]

Related Sequences to LMP003334 proteins

Reference Database Accession Length Protein Name
GI:160358825 DBBJ BAB27271.1 345 unnamed protein product [Mus musculus]
GI:160358825 EMBL CAA69401.1 323 beta-2 glycoprotein I, partial [Mus musculus]
GI:160358825 GenBank AAB30789.1 345 beta 2-glycoprotein I [Mus sp.]
GI:160358825 GenBank AAH88180.1 345 Apolipoprotein H (beta-2-glycoprotein I) [Rattus norvegicus]
GI:160358825 GenBank EDM06447.1 345 apolipoprotein H [Rattus norvegicus]
GI:160358825 RefSeq NP_001009626.1 345 beta-2-glycoprotein 1 precursor [Rattus norvegicus]