Gene/Proteome Database (LMPD)

LMPD ID
LMP003345
Gene ID
23533
Species
Homo sapiens (Human)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 5
Gene Symbol
PIK3R5
Synonyms
F730038I15Rik; FOAP-2; P101-PI3K; p101
Chromosome
17
Map Location
17p13.1
Summary
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Orthologs
View orthologs and multiple alignments for PIK3R5

Proteins

phosphoinositide 3-kinase regulatory subunit 5 isoform 1
Refseq ID NP_055123
Protein GI 217330622
UniProt ID Q8WYR1
mRNA ID NM_014308
Length 880
RefSeq Status REVIEWED
MQPGATTCTEDRIQHALERCLHGLSLSRRSTSWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTREVQEKGTYDLLTPLALLFYSTVLCTPHFPPDSDLLLKAASTYHRFLTWPVPYCSICQELLTFIDAELKAPGISYQRLVRAEQGLPIRSHRSSTVTVLLLNPVEVQAEFLAVANKLSTPGHSPHSAYTTLLLHAFQATFGAHCDVPGLHCRLQAKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAVGEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDSFDILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGHCAERDSLLSTSSLASHDSTLSLASSQASGPALSRHLLTSFVSGLSDGMDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
phosphoinositide 3-kinase regulatory subunit 5 isoform 1
Refseq ID NP_001136105
Protein GI 217330639
UniProt ID Q8WYR1
mRNA ID NM_001142633
Length 880
RefSeq Status REVIEWED
Protein sequence is identical to GI:217330622 (mRNA isoform)
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID NP_001238781
Protein GI 353411950
UniProt ID Q8WYR1
mRNA ID NM_001251852
Length 494
RefSeq Status REVIEWED
MDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID NP_001238784
Protein GI 353523787
UniProt ID Q8WYR1
mRNA ID NM_001251855
Length 494
RefSeq Status REVIEWED
Protein sequence is identical to GI:353411950 (mRNA isoform)
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID NP_001238780
Protein GI 353523783
UniProt ID Q8WYR1
mRNA ID NM_001251851
Length 494
RefSeq Status REVIEWED
Protein sequence is identical to GI:353411950 (mRNA isoform)
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID NP_001238782
Protein GI 353523785
UniProt ID Q8WYR1
mRNA ID NM_001251853
Length 494
RefSeq Status REVIEWED
Protein sequence is identical to GI:353411950 (mRNA isoform)

Gene Information

Entrez Gene ID
23533
Gene Name
phosphoinositide-3-kinase, regulatory subunit 5
Gene Symbol
PIK3R5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0016020 ISS:UniProtKB C membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005944 ISS:UniProtKB C phosphatidylinositol 3-kinase complex, class IB
GO:0046935 IEA:Ensembl F 1-phosphatidylinositol-3-kinase regulator activity
GO:0031683 ISS:UniProtKB F G-protein beta/gamma-subunit complex binding
GO:0007596 TAS:Reactome P blood coagulation
GO:0008219 IEA:UniProtKB-KW P cell death
GO:0007186 ISS:UniProtKB P G-protein coupled receptor signaling pathway
GO:0014065 ISS:UniProtKB P phosphatidylinositol 3-kinase signaling
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0030168 TAS:Reactome P platelet activation
GO:0043406 ISS:UniProtKB P positive regulation of MAP kinase activity
GO:0051897 ISS:UniProtKB P positive regulation of protein kinase B signaling
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa04024 cAMP signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells

Domain Information

InterPro Annotations

Accession Description
IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 5
Protein Entry
PI3R5_HUMAN
UniProt ID
Q8WYR1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WYR1-1; Sequence=Displayed; Name=2; IsoId=Q8WYR1-2; Sequence=VSP_016388; Note=No experimental confirmation available.;
Disease Ataxia-oculomotor apraxia 3 (AOA3) [MIM
Domain The heterodimerization region allows the binding to the catalytic subunit.
Enzyme Regulation Greatly activated by G gamma proteins.
Function Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Subcellular Location Nucleus . Cytoplasm {ECO
Subunit Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.
Tissue Specificity Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP003345 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
217330622 RefSeq NP_055123 880 phosphoinositide 3-kinase regulatory subunit 5 isoform 1
353411950 RefSeq NP_001238781 494 phosphoinositide 3-kinase regulatory subunit 5 isoform 2

Identical Sequences to LMP003345 proteins

Reference Database Accession Length Protein Name
GI:353411950 GenBank AAH28212.1 494 PIK3R5 protein [Homo sapiens]
GI:217330622 GenBank EAW90035.1 880 phosphoinositide-3-kinase, regulatory subunit 5, p101, isoform CRA_a [Homo sapiens]
GI:217330622 GenBank EAW90036.1 880 phosphoinositide-3-kinase, regulatory subunit 5, p101, isoform CRA_a [Homo sapiens]
GI:217330622 GenBank ABY87553.1 880 phosphoinositide-3-kinase, regulatory subunit 5, p101 [Homo sapiens]
GI:217330622 GenBank AGC09603.1 880 phosphoinositide-3-kinase, regulatory subunit 5 [Homo sapiens]
GI:353411950 GenBank AIC62712.1 494 PIK3R5, partial [synthetic construct]
GI:217330622 RefSeq NP_001136105.1 880 phosphoinositide 3-kinase regulatory subunit 5 isoform 1 [Homo sapiens]
GI:353411950 RefSeq NP_001238780.1 494 phosphoinositide 3-kinase regulatory subunit 5 isoform 2 [Homo sapiens]
GI:353411950 RefSeq NP_001238782.1 494 phosphoinositide 3-kinase regulatory subunit 5 isoform 2 [Homo sapiens]
GI:353411950 RefSeq NP_001238784.1 494 phosphoinositide 3-kinase regulatory subunit 5 isoform 2 [Homo sapiens]
GI:217330622 RefSeq XP_005256636.1 880 PREDICTED: phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [Homo sapiens]

Related Sequences to LMP003345 proteins

Reference Database Accession Length Protein Name
GI:217330622 GenBank AAD33397.1 880 PI3 kinase regulatory subunit P101 [Homo sapiens]
GI:217330622 GenBank AAE00191.1 880 Sequence 12 from patent US 5856132
GI:217330622 GenBank AAE62743.1 880 Sequence 2 from patent US 6200777
GI:217330622 GenBank AAE96564.1 880 Sequence 4 from patent US 6358721
GI:353411950 GenBank EAW90035.1 880 phosphoinositide-3-kinase, regulatory subunit 5, p101, isoform CRA_a [Homo sapiens]
GI:353411950 GenBank EAW90036.1 880 phosphoinositide-3-kinase, regulatory subunit 5, p101, isoform CRA_a [Homo sapiens]
GI:353411950 GenBank ABY87553.1 880 phosphoinositide-3-kinase, regulatory subunit 5, p101 [Homo sapiens]
GI:217330622 GenBank AHD75938.1 880 Sequence 18321 from patent US 8586006
GI:353411950 RefSeq NP_055123.2 880 phosphoinositide 3-kinase regulatory subunit 5 isoform 1 [Homo sapiens]
GI:353411950 RefSeq NP_001136105.1 880 phosphoinositide 3-kinase regulatory subunit 5 isoform 1 [Homo sapiens]
GI:217330622 RefSeq XP_005256637.1 879 PREDICTED: phosphoinositide 3-kinase regulatory subunit 5 isoform X2 [Homo sapiens]
GI:353411950 SwissProt Q8WYR1.1 880 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 5; Short=PI3-kinase regulatory subunit 5; AltName: Full=PI3-kinase p101 subunit; AltName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; Short=PtdIns-3-kinase regulatory subunit; AltName: Full=Protein FOAP-2; AltName: Full=PtdIns-3-kinase p101; AltName: Full=p101-PI3K [Homo sapiens]