Gene/Proteome Database (LMPD)

LMPD ID
LMP003662
Gene ID
99010
Species
Mus musculus (Mouse)
Gene Name
lysophosphatidylcholine acyltransferase 4
Gene Symbol
Lpcat4
Synonyms
AI505034; Agpat7; Aytl3; LPEAT2
Alternate Names
lysophospholipid acyltransferase LPCAT4; 1-AGPAT 7; plasmalogen synthase; acyltransferase like 3; acyltransferase-like 3; 1-AGP acyltransferase 7; 1-acylglycerophosphoserine O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; lysophosphatidylethanolamine acyltransferase 2; 1-alkylglycerophosphocholine O-acetyltransferase; 1-alkenylglycerophosphoethanolamine O-acyltransferase; -acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
Chromosome
2
Map Location
2 E3|2
EC Number
2.3.1.23

Proteins

lysophospholipid acyltransferase LPCAT4
Refseq ID NP_997089
Protein GI 46402175
UniProt ID Q6NVG1
mRNA ID NM_207206
Length 524
RefSeq Status VALIDATED
MSQGSPGAWAPLDPTSGSSASPNPFVHELHLSGLQRVKFCLLGVLLAPIRVLLAFIVLFLLWPFAWLQVAGLTEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYQPSLEESKDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGQLKVALEPQLWELAKVLQKAGLSPGFVDMGAEPGRSRMISQEAFAQQLQLSDPQTVAGAFSYFQQDAKGLVDFRNVALALAALDGGRSLEELTRLAFELFAEEQAEGSDRLLYKDGFSTILHLLLGSPRPAATTLHAELCQPGCSQGLSLCQFQNFSLHDPLYGKLFSAYLRPPHKPRSTSQIPNASSPSSPTALANGTVQAPKQKGD

Gene Information

Entrez Gene ID
99010
Gene Name
lysophosphatidylcholine acyltransferase 4
Gene Symbol
Lpcat4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISO:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047184 IEA:UniProtKB-EC F 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047166 IEA:UniProtKB-EC F 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
GO:0047192 IEA:UniProtKB-EC F 1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0071617 ISO:MGI F lysophospholipid acyltransferase activity
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0006644 ISO:MGI P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00565 Ether lipid metabolism
mmu00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893975 Acyl chain remodelling of PG
5893980 Acyl chain remodelling of PS

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
lysophosphatidylcholine acyltransferase 4
Protein Entry
LPCT4_MOUSE
UniProt ID
Q6NVG1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. {ECO:0000269|PubMed:18156367}.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. {ECO:0000269|PubMed:18156367}.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. {ECO:0000269|PubMed:18156367}.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:18156367}.
Catalytic Activity Acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine. {ECO:0000269|PubMed:18156367}.
Function Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity). Converts lysophosphatidylcholine to phosphatidycholine. {ECO:0000250, ECO:0000269|PubMed:18156367}.
Pathway Lipid metabolism; phospholipid metabolism.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed with much higher level in brain. Expressed in erythroleukemic cells but not in reticulocytes. {ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:18458083}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003662 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46402175 RefSeq NP_997089 524 lysophospholipid acyltransferase LPCAT4

Identical Sequences to LMP003662 proteins

Reference Database Accession Length Protein Name
GI:46402175 GenBank AAH68131.1 524 Lysophosphatidylcholine acyltransferase 4 [Mus musculus]
GI:46402175 GenBank EDL27834.1 524 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta) [Mus musculus]
GI:46402175 SwissProt Q6NVG1.1 524 RecName: Full=Lysophospholipid acyltransferase LPCAT4; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 7; Short=1-AGP acyltransferase 7; Short=1-AGPAT 7; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=1-acylglycerophosphoserine O-acyltransferase; AltName: Full=1-alkenylglycerophosphoethanolamine O-acyltransferase; AltName: Full=1-alkylglycerophosphocholine O-acetyltransferase; AltName: Full=Acyltransferase-like 3; AltName: Full=Lysophosphatidylcholine acyltransferase 4; AltName: Full=Lysophosphatidylethanolamine acyltransferase 2; AltName: Full=Plasmalogen synthase [Mus musculus]

Related Sequences to LMP003662 proteins

Reference Database Accession Length Protein Name
GI:46402175 GenBank AAH80829.1 524 Lysophosphatidylcholine acyltransferase 4 [Mus musculus]
GI:46402175 GenBank EDL79794.1 522 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta) (predicted) [Rattus norvegicus]
GI:46402175 GenBank EGV93165.1 524 Lysophosphatidylcholine acyltransferase 4 [Cricetulus griseus]
GI:46402175 RefSeq NP_001099964.1 522 lysophospholipid acyltransferase LPCAT4 [Rattus norvegicus]
GI:46402175 RefSeq XP_003503627.1 524 PREDICTED: lysophospholipid acyltransferase LPCAT4 [Cricetulus griseus]
GI:46402175 RefSeq XP_005364294.1 524 PREDICTED: lysophospholipid acyltransferase LPCAT4 [Microtus ochrogaster]