Gene/Proteome Database (LMPD)

LMPD ID
LMP003686
Gene ID
51205
Species
Homo sapiens (Human)
Gene Name
acid phosphatase 6, lysophosphatidic
Gene Symbol
ACP6
Synonyms
ACPL1; LPAP; PACPL1
Alternate Names
lysophosphatidic acid phosphatase type 6; acid phosphatase like 1; acid phosphatase-like protein 1; lysophosphatidic acid phosphatase 6
Chromosome
1
Map Location
1q21
EC Number
3.1.3.2

Proteins

lysophosphatidic acid phosphatase type 6 precursor
Refseq ID NP_057445
Protein GI 523498731
UniProt ID Q9NPH0
mRNA ID NM_016361
Length 428
RefSeq Status VALIDATED
MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE
transit_peptide: 1..32 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (Q9NPH0.2) calculated_mol_wt: 3591 peptide sequence: MITGVFSMRLWTPVGVLTSLAYCLHQRRVALA mat_peptide: 33..428 product: Lysophosphatidic acid phosphatase type 6 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9NPH0.2) calculated_mol_wt: 45313 peptide sequence: ELQEADGQCPVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE

Gene Information

Entrez Gene ID
51205
Gene Name
acid phosphatase 6, lysophosphatidic
Gene Symbol
ACP6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0003993 IEA:UniProtKB-EC F acid phosphatase activity
GO:0052642 IDA:UniProtKB F lysophosphatidic acid phosphatase activity
GO:0016311 IDA:GOC P dephosphorylation
GO:2001311 IDA:UniProtKB P lysobisphosphatidic acid metabolic process
GO:0006644 IMP:UniProtKB P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00740 Riboflavin metabolism
ko00740 Riboflavin metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
NADPHOS-DEPHOS-PWY NAD phosphorylation and dephosphorylation
NAD-BIOSYNTHESIS-II NAD salvage pathway II

Domain Information

InterPro Annotations

Accession Description
IPR029033 Histidine phosphatase superfamily
IPR000560 Histidine phosphatase superfamily, clade-2

UniProt Annotations

Entry Information

Gene Name
acid phosphatase 6, lysophosphatidic
Protein Entry
PPA6_HUMAN
UniProt ID
Q9NPH0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPH0-1; Sequence=Displayed; Name=2; IsoId=Q9NPH0-2; Sequence=VSP_014121, VSP_014122; Note=No experimental confirmation available.;
Catalytic Activity A phosphate monoester + H(2)O = an alcohol + phosphate.
Caution It is uncertain whether Met-1 or Met-8 is the initiator.
Caution Was originally reported to be located in the mitochondrion, but the evidence seems to be weak and contradictory with the presence of a cleaved signal sequence.
Function Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO
Induction Induced with the differentiation from myoblast to myotube.
Sequence Caution Sequence=BAA89311.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAD92485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the histidine acid phosphatase family.
Subcellular Location Mitochondrion .
Subunit Monomer.
Tissue Specificity Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP003686 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
523498731 RefSeq NP_057445 428 lysophosphatidic acid phosphatase type 6 precursor

Identical Sequences to LMP003686 proteins

Reference Database Accession Length Protein Name
GI:523498731 GenBank ADS26207.1 428 Sequence 102 from patent US 7777007
GI:523498731 GenBank ADS58588.1 428 Sequence 102 from patent US 7807385
GI:523498731 GenBank AEH74947.1 428 Sequence 6 from patent US 7956237
GI:523498731 GenBank AFL59725.1 428 Sequence 330 from patent US 8106156
GI:523498731 GenBank AHW56399.1 428 lysophosphatidic acid phosphatase 6 isoform C, partial [Homo sapiens]
GI:523498731 GenBank AIC56412.1 428 ACP6, partial [synthetic construct]

Related Sequences to LMP003686 proteins

Reference Database Accession Length Protein Name
GI:523498731 EMBL CAI15199.1 428 acid phosphatase 6, lysophosphatidic [Homo sapiens]
GI:523498731 GenBank JAA01159.1 428 acid phosphatase 6, lysophosphatidic [Pan troglodytes]
GI:523498731 GenBank AIC56413.1 428 ACP6, partial [synthetic construct]
GI:523498731 RefSeq XP_513753.3 428 PREDICTED: lysophosphatidic acid phosphatase type 6 isoform X1 [Pan troglodytes]
GI:523498731 RefSeq XP_004026556.1 428 PREDICTED: lysophosphatidic acid phosphatase type 6 [Gorilla gorilla gorilla]
GI:523498731 SwissProt Q9NPH0.2 428 RecName: Full=Lysophosphatidic acid phosphatase type 6; AltName: Full=Acid phosphatase 6, lysophosphatidic; AltName: Full=Acid phosphatase-like protein 1; AltName: Full=PACPL1; Flags: Precursor [Homo sapiens]