Gene/Proteome Database (LMPD)

LMPD ID
LMP003717
Gene ID
394436
Species
Mus musculus (Mouse)
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A1
Gene Symbol
Ugt1a1
Synonyms
Gnt1; UDPGT 1-1; UGT1A01; Udpgt-1a; UgtBr1
Alternate Names
UDP-glucuronosyltransferase 1-1; UDPGT; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1 family, polypeptide A1
Chromosome
1
Map Location
1 D|1 44.55 cM
EC Number
2.4.1.17

Proteins

UDP-glucuronosyltransferase 1-1 precursor
Refseq ID NP_964007
Protein GI 145699099
UniProt ID Q63886
mRNA ID NM_201645
Length 535
RefSeq Status VALIDATED
MTVVCWSSRLLLLLPYLLLCVFGPSASHAGRLLVFPMDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTLRKFPVPFQKENVTATLVELGRTAFNQDSFLLRVVKIYMKVKRDSSMLLAGCSHLLHNAEFMASLEESHFDALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPVPLSYVPKSLSFNSDRMNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQKEVTVQDLLSPASIWLMRSDFVKDYPRPIMPNMVFIGGINCLQKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH
sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3191 peptide sequence: MTVVCWSSRLLLLLPYLLLCVFGPSASHA mat_peptide: 30..535 product: UDP-glucuronosyltransferase 1-1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q63886.2) calculated_mol_wt: 56875 peptide sequence: GRLLVFPMDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTLRKFPVPFQKENVTATLVELGRTAFNQDSFLLRVVKIYMKVKRDSSMLLAGCSHLLHNAEFMASLEESHFDALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPVPLSYVPKSLSFNSDRMNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQKEVTVQDLLSPASIWLMRSDFVKDYPRPIMPNMVFIGGINCLQKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH

Gene Information

Entrez Gene ID
394436
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A1
Gene Symbol
Ugt1a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070069 IEA:Ensembl C cytochrome complex
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005887 IDA:MGI C integral component of plasma membrane
GO:0004857 IEA:Ensembl F enzyme inhibitor activity
GO:0015020 ISA:MGI F glucuronosyltransferase activity
GO:0001972 IEA:Ensembl F retinoic acid binding
GO:0005496 IEA:Ensembl F steroid binding
GO:0006953 IEA:Ensembl P acute-phase response
GO:0070980 IEA:Ensembl P biphenyl catabolic process
GO:0071361 IEA:Ensembl P cellular response to ethanol
GO:0071385 IEA:Ensembl P cellular response to glucocorticoid stimulus
GO:0051552 IEA:Ensembl P flavone metabolic process
GO:0052696 IEA:Ensembl P flavonoid glucuronidation
GO:0001889 IEA:Ensembl P liver development
GO:2001030 IEA:Ensembl P negative regulation of cellular glucuronidation
GO:0031100 IEA:Ensembl P organ regeneration
GO:0042493 IEA:Ensembl P response to drug
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0007584 IEA:Ensembl P response to nutrient
GO:0042594 IEA:Ensembl P response to starvation
GO:0052697 IEA:Ensembl P xenobiotic glucuronidation

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A1
Protein Entry
UD11_MOUSE
UniProt ID
Q63886
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=Q63886-1; Sequence=Displayed;
Catalytic Activity UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Induction By dioxin.
Similarity Belongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular Location Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Subunit Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Tissue Specificity Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine. {ECO:0000269|PubMed:14672974}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003717 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145699099 RefSeq NP_964007 535 UDP-glucuronosyltransferase 1-1 precursor

Identical Sequences to LMP003717 proteins

Reference Database Accession Length Protein Name
GI:145699099 GenBank AAH93516.1 535 UDP glucuronosyltransferase 1 family, polypeptide A1 [Mus musculus]
GI:145699099 SwissProt Q63886.2 535 RecName: Full=UDP-glucuronosyltransferase 1-1; Short=UDPGT 1-1; Short=UGT1*1; Short=UGT1-01; Short=UGT1.1; AltName: Full=UDP-glucuronosyltransferase 1A1; AltName: Full=UGTBR1; Flags: Precursor [Mus musculus]

Related Sequences to LMP003717 proteins

Reference Database Accession Length Protein Name
GI:145699099 GenBank AAB26033.2 535 UDP-glucuronosyltransferase [Mus sp.]
GI:145699099 GenBank AAL67852.1 535 UDP-glucuronosyltransferase 1A1 [Rattus norvegicus]
GI:145699099 GenBank AAP48593.1 535 UDP glycosyltransferase 1 family polypeptide A1 [Mus musculus]
GI:145699099 GenBank EDL40129.1 535 mCG14318, isoform CRA_i [Mus musculus]
GI:145699099 GenBank EDL92105.1 535 rCG55639, isoform CRA_c [Rattus norvegicus]
GI:145699099 PRF - 535 UDP glucuronosyltransferase [Rattus norvegicus]