Gene/Proteome Database (LMPD)
LMPD ID
LMP003735
Gene ID
Species
Homo sapiens (Human)
Gene Name
free fatty acid receptor 1
Gene Symbol
Synonyms
FFA1R; GPCR40; GPR40
Alternate Names
free fatty acid receptor 1; G protein-coupled receptor 40; G-protein coupled receptor 40
Chromosome
19
Map Location
19q13.1
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Orthologs
Proteins
| free fatty acid receptor 1 | |
|---|---|
| Refseq ID | NP_005294 |
| Protein GI | 4885327 |
| UniProt ID | O14842 |
| mRNA ID | NM_005303 |
| Length | 300 |
| RefSeq Status | REVIEWED |
| MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0005085 | TAS:Reactome | F | guanyl-nucleotide exchange factor activity |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0006112 | TAS:Reactome | P | energy reserve metabolic process |
| GO:0042593 | IEA:Ensembl | P | glucose homeostasis |
| GO:0030073 | IEA:Ensembl | P | insulin secretion |
| GO:0043547 | TAS:GOC | P | positive regulation of GTPase activity |
| GO:0050796 | TAS:Reactome | P | regulation of insulin secretion |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04911 | Insulin secretion |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_24019 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| REACT_23824 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Enzyme Regulation | The receptor is strongly activated by gamma- linolenic acid, while myristate gives a lower response. It is also activated by phytanic acid and pristanic acid (PubMed:21570468). Is also activated by synthetic agonists, such as TAK-875 (fasiglifam); this compound is a partial agonist and potentiates the activity of the endogenous ligand gamma-linolenic acid (PubMed:24130766). {ECO |
| Function | G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. {ECO |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane {ECO |
| Tissue Specificity | Detected in brain and pancreas. Detected in pancreatic beta cells. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP003735 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4885327 | RefSeq | NP_005294 | 300 | free fatty acid receptor 1 |
Identical Sequences to LMP003735 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4885327 | DBBJ | BAG74049.1 | 300 | free fatty acid receptor 1, partial [synthetic construct] |
| GI:4885327 | GenBank | ABU33413.1 | 300 | Sequence 2 from patent US 7241579 |
| GI:4885327 | GenBank | ACC10871.1 | 300 | Sequence 2 from patent US 7335481 |
| GI:4885327 | GenBank | ACH30193.1 | 300 | Sequence 250 from patent US 7410777 |
| GI:4885327 | GenBank | AEI20902.1 | 300 | Sequence 5 from patent US 7960369 |
| GI:4885327 | GenBank | AFQ84286.1 | 300 | Sequence 2 from patent US 8252521 |
Related Sequences to LMP003735 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4885327 | GenBank | AAP64876.1 | 300 | Sequence 272 from patent US 6555339 |
| GI:4885327 | GenBank | ABY87912.1 | 300 | free fatty acid receptor 1 [Homo sapiens] |
| GI:4885327 | GenBank | ACH30198.1 | 300 | Sequence 272 from patent US 7410777 |
| GI:4885327 | GenBank | AEJ67273.1 | 300 | Sequence 4 from patent US 7968552 |
| GI:4885327 | GenBank | AIC54498.1 | 300 | FFAR1, partial [synthetic construct] |
| GI:4885327 | RefSeq | XP_004060565.1 | 300 | PREDICTED: free fatty acid receptor 1 [Gorilla gorilla gorilla] |