Gene/Proteome Database (LMPD)
LMPD ID
LMP003770
Gene ID
Species
Homo sapiens (Human)
Gene Name
paraoxonase 3
Gene Symbol
Synonyms
-
Alternate Names
serum paraoxonase/lactonase 3; paraoxanase-3; arylesterase 3
Chromosome
7
Map Location
7q21.3
EC Number
3.1.1.2
Summary
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| serum paraoxonase/lactonase 3 | |
|---|---|
| Refseq ID | NP_000931 |
| Protein GI | 29788996 |
| UniProt ID | Q15166 |
| mRNA ID | NM_000940 |
| Length | 354 |
| RefSeq Status | REVIEWED |
| MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPSGLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPGSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IEA:Ensembl | C | extracellular space |
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0043231 | IEA:Ensembl | C | intracellular membrane-bounded organelle |
| GO:0018733 | IEA:Ensembl | F | 3,4-dihydrocoumarin hydrolase activity |
| GO:0004063 | IEA:UniProtKB-EC | F | aryldialkylphosphatase activity |
| GO:0004064 | NAS:UniProtKB | F | arylesterase activity |
| GO:0047856 | IEA:Ensembl | F | dihydrocoumarin hydrolase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0042803 | IDA:BHF-UCL | F | protein homodimerization activity |
| GO:0019439 | IDA:BHF-UCL | P | aromatic compound catabolic process |
| GO:0046395 | IDA:BHF-UCL | P | carboxylic acid catabolic process |
| GO:0046226 | IEA:Ensembl | P | coumarin catabolic process |
| GO:0010124 | IEA:Ensembl | P | phenylacetate catabolic process |
| GO:0009605 | NAS:UniProtKB | P | response to external stimulus |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa01100 | Metabolic pathways |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A phenyl acetate + H(2)O = a phenol + acetate. |
| Catalytic Activity | An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. |
| Catalytic Activity | An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
| Ptm | The signal sequence is not cleaved. |
| Similarity | Belongs to the paraoxonase family. |
| Subcellular Location | Secreted, extracellular space . |
| Subunit | Homodimer. |
| Web Resource | Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pon3/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP003770 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 29788996 | RefSeq | NP_000931 | 354 | serum paraoxonase/lactonase 3 |
Identical Sequences to LMP003770 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:29788996 | EMBL | CBX51401.1 | 354 | unnamed protein product [Homo sapiens] |
| GI:29788996 | GenBank | ACP57072.1 | 354 | Sequence 1201 from patent US 7482117 |
| GI:29788996 | GenBank | ADL98065.1 | 354 | Sequence 6 from patent US 7718773 |
| GI:29788996 | GenBank | ADS30669.1 | 354 | Sequence 1201 from patent US 7781168 |
| GI:29788996 | GenBank | AHE01340.1 | 354 | Sequence 56256 from patent US 8586006 |
| GI:29788996 | RefSeq | XP_003809756.1 | 354 | PREDICTED: serum paraoxonase/lactonase 3 [Pan paniscus] |
Related Sequences to LMP003770 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:29788996 | EMBL | CAD34803.1 | 354 | unnamed protein product [Homo sapiens] |
| GI:29788996 | GenBank | AAK07629.1 | 354 | paraoxanase-3, partial [Homo sapiens] |
| GI:29788996 | GenBank | AAQ40644.1 | 354 | Sequence 24 from patent US 6573370 |
| GI:29788996 | GenBank | AAH70374.1 | 354 | Paraoxonase 3 [Homo sapiens] |
| GI:29788996 | GenBank | ABA16081.1 | 354 | Sequence 24 from patent US 6916472 |
| GI:29788996 | GenBank | ADQ32083.1 | 354 | paraoxonase 3, partial [synthetic construct] |