Gene/Proteome Database (LMPD)

LMPD ID
LMP003778
Gene ID
19063
Species
Mus musculus (Mouse)
Gene Name
palmitoyl-protein thioesterase 1
Gene Symbol
Ppt1
Synonyms
9530043G02Rik; AA960502; C77813; CLN1; D4Ertd184e; INCL; PPT
Alternate Names
palmitoyl-protein thioesterase 1; PPT-1; palmitoyl-protein hydrolase 1
Chromosome
4
Map Location
4 D1-D3|4 57.27 cM
EC Number
3.1.2.22

Proteins

palmitoyl-protein thioesterase 1 precursor
Refseq ID NP_032943
Protein GI 121674797
UniProt ID O88531
mRNA ID NM_008917
Length 306
RefSeq Status VALIDATED
MASSCSRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDSCCNPMSMGVIKKMVEKEIPGIYVLSLEIGKNMMEDVENSFFLNVNVQVNMVCQILEKDPKLQQGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKLVQERLVQAQYWHDPIKESVYRNYSIFLADINQERCVNESYKKNLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQESTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK
sig_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: By similarity; propagated from UniProtKB/Swiss-Prot (O88531.2) calculated_mol_wt: 2873 peptide sequence: MASSCSRRLLAAALLPWCCAAWALGHL mat_peptide: 28..306 product: Palmitoyl-protein thioesterase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O88531.2) calculated_mol_wt: 31636 peptide sequence: DPPSPPPLVIWHGMGDSCCNPMSMGVIKKMVEKEIPGIYVLSLEIGKNMMEDVENSFFLNVNVQVNMVCQILEKDPKLQQGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKLVQERLVQAQYWHDPIKESVYRNYSIFLADINQERCVNESYKKNLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQESTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK

Gene Information

Entrez Gene ID
19063
Gene Name
palmitoyl-protein thioesterase 1
Gene Symbol
Ppt1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 ISS:UniProtKB C axon
GO:0005829 ISS:UniProtKB C cytosol
GO:0030425 IDA:MGI C dendrite
GO:0005576 ISS:UniProtKB C extracellular region
GO:0005615 IDA:MGI C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005794 ISS:UniProtKB C Golgi apparatus
GO:0005764 ISS:UniProtKB C lysosome
GO:0045121 ISS:UniProtKB C membrane raft
GO:0043025 IDA:MGI C neuronal cell body
GO:0005634 ISS:UniProtKB C nucleus
GO:0008021 ISS:UniProtKB C synaptic vesicle
GO:0016290 ISS:UniProtKB F palmitoyl-CoA hydrolase activity
GO:0008474 ISS:UniProtKB F palmitoyl-(protein) hydrolase activity
GO:0008344 IMP:MGI P adult locomotory behavior
GO:0006309 IEA:Ensembl P apoptotic DNA fragmentation
GO:0008306 IMP:MGI P associative learning
GO:0007420 IEA:Ensembl P brain development
GO:0044265 IMP:MGI P cellular macromolecule catabolic process
GO:0044257 IMP:MGI P cellular protein catabolic process
GO:0051186 ISS:UniProtKB P cofactor metabolic process
GO:0051181 ISS:UniProtKB P cofactor transport
GO:0007625 IMP:MGI P grooming behavior
GO:0016042 ISS:UniProtKB P lipid catabolic process
GO:0007042 ISS:UniProtKB P lysosomal lumen acidification
GO:0007040 IMP:MGI P lysosome organization
GO:0031579 ISS:UniProtKB P membrane raft organization
GO:0043066 ISS:UniProtKB P negative regulation of apoptotic process
GO:0030308 ISS:UniProtKB P negative regulation of cell growth
GO:0043524 ISS:UniProtKB P negative regulation of neuron apoptotic process
GO:0007399 ISS:UniProtKB P nervous system development
GO:0007269 IMP:MGI P neurotransmitter secretion
GO:0006907 IEA:Ensembl P pinocytosis
GO:0048549 ISS:UniProtKB P positive regulation of pinocytosis
GO:0048260 ISS:UniProtKB P positive regulation of receptor-mediated endocytosis
GO:0002084 ISS:UniProtKB P protein depalmitoylation
GO:0015031 ISS:UniProtKB P protein transport
GO:0006898 IBA:RefGenome P receptor-mediated endocytosis
GO:0032429 IMP:MGI P regulation of phospholipase A2 activity
GO:0007601 IMP:MGI P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
mmu00062 Fatty acid elongation
mmu01212 Fatty acid metabolism
mmu04142 Lysosome
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002472 Palmitoyl protein thioesterase

UniProt Annotations

Entry Information

Gene Name
palmitoyl-protein thioesterase 1
Protein Entry
PPT1_MOUSE
UniProt ID
O88531
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Palmitoyl-[protein] + H(2)O = palmitate + [protein].
Function Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
Ptm Glycosylated.
Sequence Caution Sequence=AAC25398.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the palmitoyl-protein thioesterase family. {ECO:0000305}.
Subcellular Location Lysosome.
Tissue Specificity Highest level in testis and kidney, lower in heart, brain and lung and lowest in skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP003778 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
121674797 RefSeq NP_032943 306 palmitoyl-protein thioesterase 1 precursor

Identical Sequences to LMP003778 proteins

Reference Database Accession Length Protein Name
GI:121674797 DBBJ BAE31725.1 306 unnamed protein product [Mus musculus]
GI:121674797 DBBJ BAE31248.1 306 unnamed protein product [Mus musculus]
GI:121674797 GenBank AAI41456.1 306 Palmitoyl-protein thioesterase 1, partial [synthetic construct]
GI:121674797 GenBank EDL30401.1 306 palmitoyl-protein thioesterase 1 [Mus musculus]
GI:121674797 GenBank AAI48715.1 306 Palmitoyl-protein thioesterase 1 [synthetic construct]
GI:121674797 SwissProt O88531.2 306 RecName: Full=Palmitoyl-protein thioesterase 1; Short=PPT-1; AltName: Full=Palmitoyl-protein hydrolase 1; Flags: Precursor [Mus musculus]

Related Sequences to LMP003778 proteins

Reference Database Accession Length Protein Name
GI:121674797 DBBJ BAE42600.1 306 unnamed protein product [Mus musculus]
GI:121674797 DBBJ BAE30117.1 306 unnamed protein product [Mus musculus]
GI:121674797 DBBJ BAE31611.1 306 unnamed protein product [Mus musculus]
GI:121674797 GenBank AAC25398.1 307 palmitoyl-protein thioesterase precursor [Mus musculus]
GI:121674797 GenBank AAL37403.1 307 palmitoyl-protein thioesterase precursor [Mus musculus]
GI:121674797 GenBank AAL37404.1 307 palmitoyl-protein thioesterase precursor [Mus musculus]