Gene/Proteome Database (LMPD)

LMPD ID
LMP003789
Gene ID
229004
Species
Mus musculus (Mouse)
Gene Name
glucocorticoid modulatory element binding protein 2
Gene Symbol
Gmeb2
Synonyms
AI839884
Alternate Names
glucocorticoid modulatory element-binding protein 2; GMEB-2
Chromosome
2
Map Location
2 H4|2

Proteins

glucocorticoid modulatory element-binding protein 2
Refseq ID NP_937812
Protein GI 37718989
UniProt ID P58929
mRNA ID NM_198169
Length 530
RefSeq Status PROVISIONAL
MATPDVSVHMEEVVVVTTPDTAVDGSGVEEVKTVLVTTNLAPHGGDLTEDNMETENAAAAAAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSTEYIPLTPAAADVNGSPATITIETCEDPGDWTTTIGDDTFAFWRGLKDAGLLDEVIQEFQQELEETMKGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVPLPSPMKRPRLARATSGPAAMASQVLTQSAQIALSPGMPVSQLTSVPLGKVVSTLPSTVLGKGSPQAAPASSPASPLLGGYTVLASSGSTFPNAVEIHPDTSSLTVLSTAAMQDGSTVLKVVSPLQLLTLPGLGPTLQNVAQASPAGSTIVTMPTATATGPEEHTATIEVAAVAEDHEQK

Gene Information

Entrez Gene ID
229004
Gene Name
glucocorticoid modulatory element binding protein 2
Gene Symbol
Gmeb2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0003713 IEA:InterPro F transcription coactivator activity
GO:0006355 IEA:UniProtKB-KW P regulation of transcription, DNA-templated
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR024830 Glucocorticoid modulatory element-binding protein 1/2
IPR000770 SAND domain
IPR010919 SAND domain-like

UniProt Annotations

Entry Information

Gene Name
glucocorticoid modulatory element binding protein 2
Protein Entry
GMEB2_MOUSE
UniProt ID
P58929
Species
Mouse

Comments

Comment Type Description
Function Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). {ECO:0000250}.
Similarity Contains 1 SAND domain. {ECO:0000255|PROSITE- ProRule:PRU00185}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00185}. Cytoplasm {ECO:0000250}. Note=May be also cytoplasmic. {ECO:0000250}.
Subunit Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB- binding protein (CBP) (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003789 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
37718989 RefSeq NP_937812 530 glucocorticoid modulatory element-binding protein 2

Identical Sequences to LMP003789 proteins

Reference Database Accession Length Protein Name
GI:37718989 GenBank EDL07401.1 530 glucocorticoid modulatory element binding protein 2 [Mus musculus]
GI:37718989 RefSeq XP_006500665.1 530 PREDICTED: glucocorticoid modulatory element-binding protein 2 isoform X1 [Mus musculus]
GI:37718989 RefSeq XP_006500666.1 530 PREDICTED: glucocorticoid modulatory element-binding protein 2 isoform X2 [Mus musculus]
GI:37718989 RefSeq XP_006500667.1 530 PREDICTED: glucocorticoid modulatory element-binding protein 2 isoform X3 [Mus musculus]
GI:37718989 RefSeq XP_006500668.1 530 PREDICTED: glucocorticoid modulatory element-binding protein 2 isoform X4 [Mus musculus]
GI:37718989 SwissProt P58929.2 530 RecName: Full=Glucocorticoid modulatory element-binding protein 2; Short=GMEB-2 [Mus musculus]

Related Sequences to LMP003789 proteins

Reference Database Accession Length Protein Name
GI:37718989 GenBank AAC64001.1 529 glucocorticoid modulatory element binding protein 2 [Rattus norvegicus]
GI:37718989 GenBank EDL88735.1 530 glucocorticoid modulatory element binding protein 2, isoform CRA_d [Rattus norvegicus]
GI:37718989 RefSeq NP_113991.1 529 glucocorticoid modulatory element-binding protein 2 [Rattus norvegicus]
GI:37718989 RefSeq XP_003503182.1 530 PREDICTED: glucocorticoid modulatory element-binding protein 2 isoform X2 [Cricetulus griseus]
GI:37718989 RefSeq XP_008841503.1 530 PREDICTED: glucocorticoid modulatory element-binding protein 2 isoform X1 [Nannospalax galili]
GI:37718989 SwissProt O88873.1 529 RecName: Full=Glucocorticoid modulatory element-binding protein 2; Short=GMEB-2 [Rattus norvegicus]