Gene/Proteome Database (LMPD)

LMPD ID
LMP003813
Gene ID
4363
Species
Homo sapiens (Human)
Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Gene Symbol
ABCC1
Synonyms
ABC29; ABCC; GS-X; MRP; MRP1
Alternate Names
multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25&26
Chromosome
16
Map Location
16p13.1
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Orthologs
View orthologs and multiple alignments for ABCC1

Proteins

multidrug resistance-associated protein 1
Refseq ID NP_004987
Protein GI 134142337
UniProt ID P33527
mRNA ID NM_004996
Length 1531
RefSeq Status REVIEWED
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV

Gene Information

Entrez Gene ID
4363
Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Gene Symbol
ABCC1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005886 IDA:HPA C plasma membrane
GO:0016887 IDA:UniProtKB F ATPase activity
GO:0042626 TAS:ProtInc F ATPase activity, coupled to transmembrane movement of substances
GO:0005524 TAS:ProtInc F ATP binding
GO:0005215 TAS:ProtInc F transporter activity
GO:0019369 TAS:Reactome P arachidonic acid metabolic process
GO:0006200 IDA:GOC P ATP catabolic process
GO:0009235 TAS:Reactome P cobalamin metabolic process
GO:0006691 TAS:Reactome P leukotriene metabolic process
GO:0042493 TAS:ProtInc P response to drug
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0055085 TAS:Reactome P transmembrane transport
GO:0006810 TAS:ProtInc P transport
GO:0006766 TAS:Reactome P vitamin metabolic process
GO:0006767 TAS:Reactome P water-soluble vitamin metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa02010 ABC transporters
hsa05206 MicroRNAs in cancer
hsa04977 Vitamin digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR011527 ABC transporter type 1, transmembrane domain
IPR005292 Multi drug resistance-associated protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Protein Entry
MRP1_HUMAN
UniProt ID
P33527
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=Allexons; IsoId=P33527-1; Sequence=Displayed; Name=2; Synonyms=Delexon-17; IsoId=P33527-2; Sequence=VSP_000037; Name=3; Synonyms=Delexon-18; IsoId=P33527-3; Sequence=VSP_000038; Name=4; Synonyms=Delexon-30; IsoId=P33527-4; Sequence=VSP_000039; Name=5; Synonyms=Delexon-17-18; IsoId=P33527-5; Sequence=VSP_000037, VSP_000038; Name=6; Synonyms=Delexon-17-30; IsoId=P33527-6; Sequence=VSP_000037, VSP_000039; Name=7; Synonyms=Delexon-18-30; IsoId=P33527-7; Sequence=VSP_000038, VSP_000039; Name=8; Synonyms=Delexon-17-18-30; IsoId=P33527-8; Sequence=VSP_000037, VSP_000038, VSP_000039; Name=9; IsoId=P33527-9; Sequence=VSP_017014; Note=No experimental confirmation available.;
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO
Similarity Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Similarity Contains 2 ABC transmembrane type-1 domains.
Similarity Contains 2 ABC transporter domains.
Subcellular Location Cell membrane ; Multi-pass membrane protein {ECO
Tissue Specificity Lung, testis and peripheral blood mononuclear cells.
Web Resource Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527";
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MRPID106.html";
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/abcc1/";

Identical and Related Proteins

Unique RefSeq proteins for LMP003813 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
134142337 RefSeq NP_004987 1531 multidrug resistance-associated protein 1

Identical Sequences to LMP003813 proteins

Reference Database Accession Length Protein Name
GI:134142337 GenBank ABN79590.1 1531 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Homo sapiens]
GI:134142337 GenBank AAI56354.1 1531 ATP-binding cassette, sub-family C (CFTR/MRP), member 1, partial [synthetic construct]
GI:134142337 GenBank AAI57106.1 1531 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [synthetic construct]
GI:134142337 SwissProt P33527.3 1531 RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter [Homo sapiens]

Related Sequences to LMP003813 proteins

Reference Database Accession Length Protein Name
GI:134142337 GenBank AAB46616.1 1531 multidrug resistance-associated protein [Homo sapiens]
GI:134142337 GenBank AAE24086.1 1531 Sequence 4 from patent US 5891724
GI:134142337 GenBank AAE40249.1 1531 Sequence 4 from patent US 6001563
GI:134142337 GenBank ABE18305.1 1531 Sequence 86 from patent US 6989232
GI:134142337 GenBank ABH96294.1 1531 Sequence 6 from patent US 7067259
GI:134142337 GenBank ABZ19107.1 1531 Sequence 19 from patent US 7312026