Gene/Proteome Database (LMPD)

LMPD ID
LMP003825
Gene ID
80168
Species
Homo sapiens (Human)
Gene Name
monoacylglycerol O-acyltransferase 2
Gene Symbol
MOGAT2
Synonyms
DGAT2L5; MGAT2
Alternate Names
2-acylglycerol O-acyltransferase 2; hDC5; hMGAT2; acyl CoA:monoacylglycerol acyltransferase 2; acyl-CoA:monoacylglycerol acyltransferase 2; diacylglycerol O-acyltransferase candidate 5; diacylglycerol acyltransferase 2-like protein 5
Chromosome
11
Map Location
11q13.5
EC Number
2.3.1.22
Summary
Dietary fat absorption from the small intestine is facilitated by acyl-CoA:monoacylglycerol transferase (MOGAT; EC 2.3.1.22) and acyl-CoA:diacylglycerol acyltransferase (DGAT; see MIM 604900) activities. MOGAT catalyzes the joining of monoacylglycerol and fatty acyl-CoAs to form diacylglycerol (Yen and Farese, 2003 [PubMed 12621063]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for MOGAT2

Proteins

2-acylglycerol O-acyltransferase 2
Refseq ID NP_079374
Protein GI 37537527
UniProt ID Q3SYC2
mRNA ID NM_025098
Length 334
RefSeq Status PROVISIONAL
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC

Gene Information

Entrez Gene ID
80168
Gene Name
monoacylglycerol O-acyltransferase 2
Gene Symbol
MOGAT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003846 IEA:UniProtKB-EC F 2-acylglycerol O-acyltransferase activity
GO:0016407 IEA:Ensembl F acetyltransferase activity
GO:0006651 IEA:Ensembl P diacylglycerol biosynthetic process
GO:0006071 IEA:UniProtKB-KW P glycerol metabolic process
GO:0050892 IEA:Ensembl P intestinal absorption
GO:0019432 IEA:UniProtKB-UniPathway P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
ko04975 Fat digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR007130 Diacylglycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
monoacylglycerol O-acyltransferase 2
Protein Entry
MOGT2_HUMAN
UniProt ID
Q3SYC2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3SYC2-1; Sequence=Displayed; Name=2; IsoId=Q3SYC2-2; Sequence=VSP_020358; Note=No experimental confirmation available.; Name=3; Synonyms=MGAT2V, Trunc; IsoId=Q3SYC2-3; Sequence=VSP_020359, VSP_020360;
Biophysicochemical Properties Kinetic parameters: KM=45 uM for sn-1-monooleoylglycerol ;
Catalytic Activity Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Enzyme Regulation Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.
Function Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.
Pathway Glycerolipid metabolism; triacylglycerol biosynthesis.
Similarity Belongs to the diacylglycerol acyltransferase family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Highly expressed in liver, small intestine, colon, stomach and kidney. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP003825 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
37537527 RefSeq NP_079374 334 2-acylglycerol O-acyltransferase 2

Identical Sequences to LMP003825 proteins

Reference Database Accession Length Protein Name
GI:37537527 GenBank AFQ73191.1 334 Sequence 2 from patent US 8232447
GI:37537527 GenBank AGC98162.1 334 Sequence 2 from patent US 8334111
GI:37537527 GenBank AGX59580.1 334 Sequence 19439 from patent US 8541208
GI:37537527 GenBank AGX72245.1 334 Sequence 44289 from patent US 8541208
GI:37537527 GenBank AHD78079.1 334 Sequence 25058 from patent US 8586006
GI:37537527 GenBank AIC52367.1 334 MOGAT2, partial [synthetic construct]

Related Sequences to LMP003825 proteins

Reference Database Accession Length Protein Name
GI:37537527 GenBank AAI03878.1 334 Monoacylglycerol O-acyltransferase 2 [Homo sapiens]
GI:37537527 GenBank EHH23258.1 334 hypothetical protein EGK_06693 [Macaca mulatta]
GI:37537527 GenBank EHH56594.1 334 hypothetical protein EGM_06042 [Macaca fascicularis]
GI:37537527 RefSeq XP_003910482.1 334 PREDICTED: 2-acylglycerol O-acyltransferase 2 [Papio anubis]
GI:37537527 RefSeq XP_005579169.1 334 PREDICTED: 2-acylglycerol O-acyltransferase 2 isoform X1 [Macaca fascicularis]
GI:37537527 RefSeq XP_008018375.1 334 PREDICTED: 2-acylglycerol O-acyltransferase 2 [Chlorocebus sabaeus]