Gene/Proteome Database (LMPD)
LMPD ID
LMP003827
Gene ID
Species
Homo sapiens (Human)
Gene Name
diacylglycerol lipase, alpha
Gene Symbol
Synonyms
C11orf11; DAGL(ALPHA); DAGLALPHA; NSDDR
Alternate Names
sn1-specific diacylglycerol lipase alpha; DGL-alpha; neural stem cell-derived dendrite regulator
Chromosome
11
Map Location
11q12.2
EC Number
3.1.1.-
Summary
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
Orthologs
Proteins
| sn1-specific diacylglycerol lipase alpha | |
|---|---|
| Refseq ID | NP_006124 |
| Protein GI | 27262632 |
| UniProt ID | Q9Y4D2 |
| mRNA ID | NM_006133 |
| Length | 1042 |
| RefSeq Status | REVIEWED |
| MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0016787 | IEA:UniProtKB-KW | F | hydrolase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0019369 | IDA:UniProtKB | P | arachidonic acid metabolic process |
| GO:0007596 | TAS:Reactome | P | blood coagulation |
| GO:0008219 | IEA:UniProtKB-KW | P | cell death |
| GO:0046340 | IDA:UniProtKB | P | diacylglycerol catabolic process |
| GO:0071926 | IEA:Ensembl | P | endocannabinoid signaling pathway |
| GO:0007405 | IEA:Ensembl | P | neuroblast proliferation |
| GO:0042136 | IDA:UniProtKB | P | neurotransmitter biosynthetic process |
| GO:0030168 | TAS:Reactome | P | platelet activation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04723 | Retrograde endocannabinoid signaling |
| ko04723 | Retrograde endocannabinoid signaling |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19308 | Arachidonate production from DAG |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | Kinetic parameters: KM=154.7 uM for diacylglycerol ; Vmax=33.3 nmol/min/mg enzyme ; pH dependence: Optimum pH is 7.0. ; |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Disease | Spinocerebellar ataxia 20 (SCA20) [MIM |
| Enzyme Regulation | Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation. |
| Function | Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. |
| Sequence Caution | Sequence=BAA31634.2; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in brain and pancreas. |
Identical and Related Proteins
Unique RefSeq proteins for LMP003827 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 27262632 | RefSeq | NP_006124 | 1042 | sn1-specific diacylglycerol lipase alpha |
Identical Sequences to LMP003827 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:27262632 | DBBJ | BAG09800.1 | 1042 | Sn1-specific diacylglycerol lipase alpha, partial [synthetic construct] |
| GI:27262632 | GenBank | EAW73961.1 | 1042 | chromosome 11 open reading frame 11, isoform CRA_b [Homo sapiens] |
| GI:27262632 | GenBank | AAI50177.1 | 1042 | Diacylglycerol lipase, alpha [Homo sapiens] |
| GI:27262632 | GenBank | AAI50196.1 | 1042 | Diacylglycerol lipase, alpha [Homo sapiens] |
| GI:27262632 | GenBank | AAI52454.1 | 1042 | Diacylglycerol lipase, alpha [Homo sapiens] |
| GI:27262632 | RefSeq | XP_005274287.1 | 1042 | PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X1 [Homo sapiens] |
Related Sequences to LMP003827 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:27262632 | DBBJ | BAA31634.2 | 1049 | KIAA0659 protein, partial [Homo sapiens] |
| GI:27262632 | GenBank | JAA09856.1 | 1042 | diacylglycerol lipase, alpha [Pan troglodytes] |
| GI:27262632 | GenBank | JAA24925.1 | 1042 | diacylglycerol lipase, alpha [Pan troglodytes] |
| GI:27262632 | RefSeq | XP_002821724.1 | 1043 | PREDICTED: sn1-specific diacylglycerol lipase alpha [Pongo abelii] |
| GI:27262632 | RefSeq | XP_003828506.1 | 1042 | PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X1 [Pan paniscus] |
| GI:27262632 | RefSeq | XP_009244542.1 | 1043 | PREDICTED: sn1-specific diacylglycerol lipase alpha [Pongo abelii] |