Gene/Proteome Database (LMPD)

LMPD ID
LMP003839
Gene ID
118788
Species
Homo sapiens (Human)
Gene Name
phosphoinositide-3-kinase adaptor protein 1
Gene Symbol
PIK3AP1
Synonyms
BCAP
Alternate Names
phosphoinositide 3-kinase adapter protein 1; B cell adaptor protein; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1
Chromosome
10
Map Location
10q24.1

Proteins

phosphoinositide 3-kinase adapter protein 1
Refseq ID NP_689522
Protein GI 45505139
UniProt ID Q6ZUJ8
mRNA ID NM_152309
Length 805
RefSeq Status VALIDATED
MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILTHRLGPEASFSAEDLSLFLSTRCVVVLLSAELVQHFHKPALLPLLQRAFHPPHRVVRLLCGVRDSEEFLDFFPDWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPGNLMVVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMHGEEADAVYESMAHLSTDLLMKCSLNPGCDEDLYESMAAFVPAATEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVYHTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRAASQRPPTRETFHPPPPVPPRGR

Gene Information

Entrez Gene ID
118788
Gene Name
phosphoinositide-3-kinase adaptor protein 1
Gene Symbol
PIK3AP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0016020 ISS:UniProtKB C membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0036312 ISS:UniProtKB F phosphatidylinositol 3-kinase regulatory subunit binding
GO:0034122 IEA:Ensembl P negative regulation of toll-like receptor signaling pathway
GO:0014068 ISS:UniProtKB P positive regulation of phosphatidylinositol 3-kinase signaling
GO:0034123 IEA:Ensembl P positive regulation of toll-like receptor signaling pathway
GO:0050727 ISS:UniProtKB P regulation of inflammatory response
GO:0034134 ISS:UniProtKB P toll-like receptor 2 signaling pathway
GO:0034142 ISS:UniProtKB P toll-like receptor 4 signaling pathway
GO:0034154 ISS:UniProtKB P toll-like receptor 7 signaling pathway
GO:0034162 ISS:UniProtKB P toll-like receptor 9 signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
hsa04662 B cell receptor signaling pathway
hsa04151 PI3K-Akt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_118700 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Domain Information

InterPro Annotations

Accession Description
IPR017893 DBB_domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase adaptor protein 1
Protein Entry
BCAP_HUMAN
UniProt ID
Q6ZUJ8
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=BCAP-L; IsoId=Q6ZUJ8-1; Sequence=Displayed; Name=2; Synonyms=BCAP-S; IsoId=Q6ZUJ8-2; Sequence=VSP_034238; Name=3; IsoId=Q6ZUJ8-3; Sequence=VSP_034239, VSP_034240;
Domain The DBB domain is required for dimerization.
Function Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Ptm Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity). Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity). Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).
Similarity Contains 1 DBB domain. {ECO
Subcellular Location Cytoplasm . Cell membrane {ECO
Subunit Homooligomer (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP (By similarity).
Tissue Specificity Expressed in natural killer (NK) cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP003839 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45505139 RefSeq NP_689522 805 phosphoinositide 3-kinase adapter protein 1

Identical Sequences to LMP003839 proteins

Reference Database Accession Length Protein Name
GI:45505139 EMBL CCQ77684.1 805 unnamed protein product [Homo sapiens]
GI:45505139 GenBank EAW49968.1 805 phosphoinositide-3-kinase adaptor protein 1, isoform CRA_a [Homo sapiens]
GI:45505139 GenBank AHD75937.1 805 Sequence 18320 from patent US 8586006
GI:45505139 SwissProt Q6ZUJ8.2 805 RecName: Full=Phosphoinositide 3-kinase adapter protein 1; AltName: Full=B-cell adapter for phosphoinositide 3-kinase; AltName: Full=B-cell phosphoinositide 3-kinase adapter protein 1 [Homo sapiens]

Related Sequences to LMP003839 proteins

Reference Database Accession Length Protein Name
GI:45505139 DBBJ BAC86227.1 805 unnamed protein product [Homo sapiens]
GI:45505139 EMBL CAL37947.1 805 hypothetical protein, partial [synthetic construct]
GI:45505139 GenBank EAW49969.1 815 phosphoinositide-3-kinase adaptor protein 1, isoform CRA_b [Homo sapiens]
GI:45505139 RefSeq XP_507955.2 805 PREDICTED: phosphoinositide 3-kinase adapter protein 1 isoform X1 [Pan troglodytes]
GI:45505139 RefSeq XP_003825463.1 805 PREDICTED: phosphoinositide 3-kinase adapter protein 1 [Pan paniscus]
GI:45505139 RefSeq XP_004049918.1 805 PREDICTED: phosphoinositide 3-kinase adapter protein 1 isoform 1 [Gorilla gorilla gorilla]