Gene/Proteome Database (LMPD)

LMPD ID
LMP003908
Gene ID
18979
Species
Mus musculus (Mouse)
Gene Name
paraoxonase 1
Gene Symbol
Pon1
Synonyms
Pon
Alternate Names
serum paraoxonase/arylesterase 1; PON 1; A-esterase 1; aromatic esterase 1; serum aryldialkylphosphatase 1
Chromosome
6
Map Location
6 A2|6 1.99 cM
EC Number
3.1.1.2

Proteins

serum paraoxonase/arylesterase 1 precursor
Refseq ID NP_035264
Protein GI 261823995
UniProt ID P52430
mRNA ID NM_011134
Length 355
RefSeq Status VALIDATED
MAKLLALTLVGLVLALYKNHRSSYQTRLNAFREVTPVELPNCNLVKGIETGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNKKEPAVSELEIIGNTLDISSFNPHGISTFTDEDNTVYLLVVNHPDSSSTVEVFKFQEEERSLLHLKTITHELLPSINDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAEGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLNFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDAENPPGSEVLRIQNILSEDPKITVVYAENGTVLQGTTVASVYKGKLLIGTVFHKALYCDL
sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1526 peptide sequence: MAKLLALTLVGLVLA

Gene Information

Entrez Gene ID
18979
Gene Name
paraoxonase 1
Gene Symbol
Pon1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IEA:Ensembl C blood microparticle
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0043231 IEA:Ensembl C intracellular membrane-bounded organelle
GO:0034366 IEA:Ensembl C spherical high-density lipoprotein particle
GO:0004063 ISS:UniProtKB F aryldialkylphosphatase activity
GO:0004064 ISS:UniProtKB F arylesterase activity
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0008035 TAS:MGI F high-density lipoprotein particle binding
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0019439 IEA:Ensembl P aromatic compound catabolic process
GO:0008015 TAS:MGI P blood circulation
GO:0046395 IEA:Ensembl P carboxylic acid catabolic process
GO:0008203 IMP:MGI P cholesterol metabolic process
GO:0016311 ISS:GOC P dephosphorylation
GO:0046434 IEA:Ensembl P organophosphate catabolic process
GO:0046470 IEA:Ensembl P phosphatidylcholine metabolic process
GO:0051099 IEA:Ensembl P positive regulation of binding
GO:0010875 IEA:Ensembl P positive regulation of cholesterol efflux
GO:0032411 IEA:Ensembl P positive regulation of transporter activity
GO:0009636 IMP:MGI P response to toxic substance

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5490 paraoxon degradation
PARATHION-DEGRADATION-PWY parathion degradation

Domain Information

InterPro Annotations

Accession Description
IPR002640 Arylesterase
IPR008363 Paraoxonase1
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
paraoxonase 1
Protein Entry
PON1_MOUSE
UniProt ID
P52430
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A phenyl acetate + H(2)O = a phenol + acetate. {ECO:0000269|PubMed:15963993}.
Catalytic Activity An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. {ECO:0000269|PubMed:15963993}.
Catalytic Activity An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. {ECO:0000269|PubMed:15963993}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250};
Function Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification (By similarity). {ECO:0000250}.
Miscellaneous The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces (By similarity). {ECO:0000250}.
Ptm The signal sequence is not cleaved. {ECO:0000250}.
Similarity Belongs to the paraoxonase family. {ECO:0000305}.
Subcellular Location Secreted, extracellular space.
Subunit Homodimer. Interacts with CLU (By similarity). {ECO:0000250}.
Tissue Specificity Plasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL.

Identical and Related Proteins

Unique RefSeq proteins for LMP003908 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
261823995 RefSeq NP_035264 355 serum paraoxonase/arylesterase 1 precursor

Identical Sequences to LMP003908 proteins

Reference Database Accession Length Protein Name
GI:261823995 GenBank AAA99445.1 355 paraoxonase [Mus musculus domesticus]
GI:261823995 GenBank AAB17394.1 355 paraoxonase [Mus musculus]
GI:261823995 GenBank EDL13971.1 355 paraoxonase 1, isoform CRA_a [Mus musculus]
GI:261823995 GenBank ADL98068.1 355 Sequence 9 from patent US 7718773
GI:261823995 SwissProt P52430.2 355 RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=Serum aryldialkylphosphatase 1 [Mus musculus]

Related Sequences to LMP003908 proteins

Reference Database Accession Length Protein Name
GI:261823995 GenBank AAC52496.1 355 serum paraoxonase [Mus musculus]
GI:261823995 GenBank AAH12706.1 355 Paraoxonase 1 [Mus musculus]
GI:261823995 GenBank AAH91403.1 355 Paraoxonase 1 [Rattus norvegicus]
GI:261823995 GenBank EDM15017.1 355 paraoxonase 1, isoform CRA_a [Rattus norvegicus]
GI:261823995 RefSeq NP_114466.1 355 serum paraoxonase/arylesterase 1 precursor [Rattus norvegicus]
GI:261823995 SwissProt P55159.3 355 RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=Serum aryldialkylphosphatase 1 [Rattus norvegicus]