Gene/Proteome Database (LMPD)

LMPD ID
LMP003912
Gene ID
18779
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2 receptor 1
Gene Symbol
Pla2r1
Synonyms
Pla2-r; Pla2g1br; Pla2r
Alternate Names
secretory phospholipase A2 receptor; M-type receptor; PLA2-I receptor; 180 kDa secretory phospholipase A2 receptor; phospholipase A2, group IB, pancreas, receptor
Chromosome
2
Map Location
2 C1.1|2

Proteins

secretory phospholipase A2 receptor precursor
Refseq ID NP_032893
Protein GI 6679365
UniProt ID Q62028
mRNA ID NM_008867
Length 1487
RefSeq Status VALIDATED
MVQWLAMLQLLWLQQLLLLGIHQGIAQDLTHIQEPSLEWRDKGIFIIQSESLKTCIQAGKSVLTLENCKQPNEHMLWKWVSDDHLFNVGGSGCLGLNISALEQPLKLYECDSTLISLRWHCDRKMIEGPLQYKVQVKSDNTVVARKQIHRWIAYTSSGGDICEHPSRDLYTLKGNAHGMPCVFPFQFKGHWHHDCIREGQKEHLLWCATTSRYEEDEKWGFCPDPTSMKVFCDATWQRNGSSRICYQFNLLSSLSWNQAHSSCLMQGGALLSIADEDEEDFIRKHLSKVVKEVWIGLNQLDEKAGWQWSDGTPLSYLNWSQEITPGPFVEHHCGTLEVVSAAWRSRDCESTLPYICKRDLNHTAQGILEKDSWKYHATHCDPDWTPFNRKCYKLKKDRKSWLGALHSCQSNDSVLMDVASLAEVEFLVSLLRDENASETWIGLSSNKIPVSFEWSSGSSVIFTNWYPLEPRILPNRRQLCVSAEESDGRWKVKDCKERLFYICKKAGQVPADEQSGCPAGWERHGRFCYKIDTVLRSFEEASSGYYCSPALLTITSRFEQAFITSLISSVAEKDSYFWIALQDQNNTGEYTWKTVGQREPVQYTYWNTRQPSNRGGCVVVRGGSSLGRWEVKDCSDFKAMSLCKTPVKIWEKTELEERWPFHPCYMDWESATGLASCFKVFHSEKVLMKRSWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTQERQFWIGFNRRNPLNAGSWAWSDGSPVVSSFLDNAYFEEDAKNCAVYKANKTLLPSNCASKHEWICRIPRDVRPKFPDWYQYDAPWLFYQNAEYLFHTHPAEWATFEFVCGWLRSDFLTIYSAQEQEFIHSKIKGLTKYGVKWWIGLEEGGARDQIQWSNGSPVIFQNWDKGREERVDSQRKRCVFISSITGLWGTENCSVPLPSICKRVKIWVIEKEKPPTQPGTCPKGWLYFNYKCFLVTIPKDPRELKTWTGAQEFCVAKGGTLVSIKSELEQAFITMNLFGQTTNVWIGLQSTNHEKWVNGKPLVYSNWSPSDIINIPSYNTTEFQKHIPLCALMSSNPNFHFTGKWYFDDCGKEGYGFVCEKMQDTLEHHVNVSDTSAIPSTLEYGNRTYKIIRGNMTWYAAGKSCRMHRAELASIPDAFHQAFLTVLLSRLGHTHWIGLSTTDNGQTFDWSDGTKSPFTYWKDEESAFLGDCAFADTNGRWHSTACESFLQGAICHVVTETKAFEHPGLCSETSVPWIKFKGNCYSFSTVLDSRSFEDAHEFCKSEGSNLLAIRDAAENSFLLEELLAFGSSVQMVWLNAQFDNNNKTLRWFDGTPTEQSNWGLRKPDMDHLKPHPCVVLRIPEGIWHFTPCEDKKGFICKMEAGIPAVTAQPEKGLSHSIVPVTVTLTLIIALGIFMLCFWIYKQKSDIFQRLTGSRGSYYPTLNFSTAHLEENILISDLEKNTNDEEVRDAPATESKRGHKGRPICISP
sig_peptide: 1..26 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3031 peptide sequence: MVQWLAMLQLLWLQQLLLLGIHQGIA mat_peptide: 27..1487 product: Secretory phospholipase A2 receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q62028.1) calculated_mol_wt: 167500 peptide sequence: QDLTHIQEPSLEWRDKGIFIIQSESLKTCIQAGKSVLTLENCKQPNEHMLWKWVSDDHLFNVGGSGCLGLNISALEQPLKLYECDSTLISLRWHCDRKMIEGPLQYKVQVKSDNTVVARKQIHRWIAYTSSGGDICEHPSRDLYTLKGNAHGMPCVFPFQFKGHWHHDCIREGQKEHLLWCATTSRYEEDEKWGFCPDPTSMKVFCDATWQRNGSSRICYQFNLLSSLSWNQAHSSCLMQGGALLSIADEDEEDFIRKHLSKVVKEVWIGLNQLDEKAGWQWSDGTPLSYLNWSQEITPGPFVEHHCGTLEVVSAAWRSRDCESTLPYICKRDLNHTAQGILEKDSWKYHATHCDPDWTPFNRKCYKLKKDRKSWLGALHSCQSNDSVLMDVASLAEVEFLVSLLRDENASETWIGLSSNKIPVSFEWSSGSSVIFTNWYPLEPRILPNRRQLCVSAEESDGRWKVKDCKERLFYICKKAGQVPADEQSGCPAGWERHGRFCYKIDTVLRSFEEASSGYYCSPALLTITSRFEQAFITSLISSVAEKDSYFWIALQDQNNTGEYTWKTVGQREPVQYTYWNTRQPSNRGGCVVVRGGSSLGRWEVKDCSDFKAMSLCKTPVKIWEKTELEERWPFHPCYMDWESATGLASCFKVFHSEKVLMKRSWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTQERQFWIGFNRRNPLNAGSWAWSDGSPVVSSFLDNAYFEEDAKNCAVYKANKTLLPSNCASKHEWICRIPRDVRPKFPDWYQYDAPWLFYQNAEYLFHTHPAEWATFEFVCGWLRSDFLTIYSAQEQEFIHSKIKGLTKYGVKWWIGLEEGGARDQIQWSNGSPVIFQNWDKGREERVDSQRKRCVFISSITGLWGTENCSVPLPSICKRVKIWVIEKEKPPTQPGTCPKGWLYFNYKCFLVTIPKDPRELKTWTGAQEFCVAKGGTLVSIKSELEQAFITMNLFGQTTNVWIGLQSTNHEKWVNGKPLVYSNWSPSDIINIPSYNTTEFQKHIPLCALMSSNPNFHFTGKWYFDDCGKEGYGFVCEKMQDTLEHHVNVSDTSAIPSTLEYGNRTYKIIRGNMTWYAAGKSCRMHRAELASIPDAFHQAFLTVLLSRLGHTHWIGLSTTDNGQTFDWSDGTKSPFTYWKDEESAFLGDCAFADTNGRWHSTACESFLQGAICHVVTETKAFEHPGLCSETSVPWIKFKGNCYSFSTVLDSRSFEDAHEFCKSEGSNLLAIRDAAENSFLLEELLAFGSSVQMVWLNAQFDNNNKTLRWFDGTPTEQSNWGLRKPDMDHLKPHPCVVLRIPEGIWHFTPCEDKKGFICKMEAGIPAVTAQPEKGLSHSIVPVTVTLTLIIALGIFMLCFWIYKQKSDIFQRLTGSRGSYYPTLNFSTAHLEENILISDLEKNTNDEEVRDAPATESKRGHKGRPICISP

Gene Information

Entrez Gene ID
18779
Gene Name
phospholipase A2 receptor 1
Gene Symbol
Pla2r1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IDA:UniProtKB C extracellular region
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0043235 ISO:MGI C receptor complex
GO:0030246 IEA:UniProtKB-KW F carbohydrate binding
GO:0043274 IPI:UniProtKB F phospholipase binding
GO:0004872 ISS:UniProtKB F receptor activity
GO:0001816 ISS:UniProtKB P cytokine production
GO:1900139 IDA:UniProtKB P negative regulation of arachidonic acid secretion
GO:1900138 IDA:UniProtKB P negative regulation of phospholipase A2 activity
GO:0090403 ISS:UniProtKB P oxidative stress-induced premature senescence
GO:0043517 ISS:UniProtKB P positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090238 IDA:UniProtKB P positive regulation of arachidonic acid secretion
GO:0072593 ISS:UniProtKB P reactive oxygen species metabolic process
GO:0006898 IDA:UniProtKB P receptor-mediated endocytosis
GO:0090399 ISS:UniProtKB P replicative senescence

KEGG Pathway Links

KEGG Pathway ID Description
mmu04145 Phagosome
mmu05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR018378 C-type lectin, conserved site
IPR001304 C-type_lectin
IPR016186 C-type_lectin-like
IPR016187 C-type_lectin_fold
IPR000562 Fibronectin, type II, collagen-binding
IPR000772 Ricin B lectin domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2 receptor 1
Protein Entry
PLA2R_MOUSE
UniProt ID
Q62028
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62028-1; Sequence=Displayed; Name=2; IsoId=Q62028-2; Sequence=VSP_029495, VSP_029496; Note=No experimental confirmation available.;
Disruption Phenotype Mice are viable, fertile and without evident histopathological abnormalities. After challenge with bacterial lipopolysaccharide (LPS), they exhibit longer survival than wild- type mice. They are also resistant to lethal effects of exogenous sPLA2-IB/PLA2G1B after sensitization with sublethal dose of LPS, suggesting a potential role in the progression of endotoxic shock. {ECO:0000269|PubMed:9407054}.
Domain C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B. {ECO:0000269|PubMed:7925459}.
Domain The endocytosis signal probably mediates endocytosis via clathrin-coated pits. {ECO:0000250}.
Function Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. {ECO:0000269|PubMed:10922494, ECO:0000269|PubMed:10946309, ECO:0000269|PubMed:11019817, ECO:0000269|PubMed:11481246, ECO:0000269|PubMed:11741598, ECO:0000269|PubMed:11830583, ECO:0000269|PubMed:12225974, ECO:0000269|PubMed:16815622, ECO:0000269|PubMed:17279628, ECO:0000269|PubMed:7925459, ECO:0000269|PubMed:9407054}.
Induction Following exposure to endotoxin (at protein level). {ECO:0000269|PubMed:10864436}.
Ptm The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments reported by PubMed:11830583, or by alternative splicing.
Sequence Caution Sequence=CAM22305.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM23630.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Contains 1 fibronectin type-II domain. {ECO:0000255|PROSITE-ProRule:PRU00479}.
Similarity Contains 1 ricin B-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00174}.
Similarity Contains 8 C-type lectin domains. {ECO:0000255|PROSITE-ProRule:PRU00040}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11830583}; Single-pass type I membrane protein {ECO:0000269|PubMed:11830583}.
Subcellular Location Soluble secretory phospholipase A2 receptor: Secreted.
Tissue Specificity Widely expressed. Present in type II alveolar epithelial cells and a subset of splenic lymphocytes. Present at the surface of polymorphonuclear neutrophils (at protein level). {ECO:0000269|PubMed:10864436, ECO:0000269|PubMed:12225974, ECO:0000269|PubMed:7925459}.
Web Resource Name=Functional Glycomics Gateway - Glycan Binding; Note=Phospholipase A2 receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_356";

Identical and Related Proteins

Unique RefSeq proteins for LMP003912 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679365 RefSeq NP_032893 1487 secretory phospholipase A2 receptor precursor

Identical Sequences to LMP003912 proteins

Reference Database Accession Length Protein Name
GI:6679365 GenBank AAI41356.1 1487 Phospholipase A2 receptor 1 [Mus musculus]
GI:6679365 GenBank AAI41357.1 1487 Phospholipase A2 receptor 1 [Mus musculus]
GI:6679365 GenBank AEU43256.1 1487 Sequence 5 from patent US 8052970
GI:6679365 GenBank AEU43325.1 1487 Sequence 74 from patent US 8052970
GI:6679365 GenBank AEU43338.1 1487 Sequence 87 from patent US 8052970
GI:6679365 SwissProt Q62028.1 1487 RecName: Full=Secretory phospholipase A2 receptor; Short=PLA2-R; Short=PLA2R; AltName: Full=180 kDa secretory phospholipase A2 receptor; AltName: Full=M-type receptor; Contains: RecName: Full=Soluble secretory phospholipase A2 receptor; Short=Soluble PLA2-R; Short=Soluble PLA2R; Flags: Precursor [Mus musculus]

Related Sequences to LMP003912 proteins

Reference Database Accession Length Protein Name
GI:6679365 GenBank EDL26964.1 1522 phospholipase A2 receptor 1 [Mus musculus]
GI:6679365 GenBank ACC03098.1 1522 Sequence 33 from patent US 7332281
GI:6679365 GenBank AEU43398.1 1522 Sequence 147 from patent US 8052970
GI:6679365 GenBank AEU43399.1 1522 Sequence 148 from patent US 8052970
GI:6679365 GenBank AEU43411.1 1522 Sequence 160 from patent US 8052970
GI:6679365 RefSeq XP_006498991.1 1395 PREDICTED: secretory phospholipase A2 receptor isoform X1 [Mus musculus]