Gene/Proteome Database (LMPD)

LMPD ID
LMP003948
Gene ID
1429
Species
Homo sapiens (Human)
Gene Name
crystallin, zeta (quinone reductase)
Gene Symbol
CRYZ
Synonyms
-
Alternate Names
quinone oxidoreductase; NADPH:quinone reductase
Chromosome
1
Map Location
1p31.1
EC Number
1.6.5.5
Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
Orthologs
View orthologs and multiple alignments for CRYZ

Proteins

quinone oxidoreductase isoform a
Refseq ID NP_001880
Protein GI 13236495
UniProt ID Q08257
mRNA ID NM_001889
Length 329
RefSeq Status REVIEWED
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL
quinone oxidoreductase isoform a
Refseq ID NP_001123514
Protein GI 194239674
UniProt ID Q08257
mRNA ID NM_001130042
Length 329
RefSeq Status REVIEWED
Protein sequence is identical to GI:13236495 (mRNA isoform)
quinone oxidoreductase isoform b
Refseq ID NP_001123515
Protein GI 194239674
UniProt ID Q08257
mRNA ID NM_001130043
Length 329
RefSeq Status REVIEWED
Protein sequence is identical to GI:13236495 (mRNA isoform)
quinone oxidoreductase isoform c
Refseq ID NP_001128231
Protein GI 197927207
UniProt ID Q08257
mRNA ID NM_001134759
Length 192
RefSeq Status REVIEWED
MHLLSSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL

Gene Information

Entrez Gene ID
1429
Gene Name
crystallin, zeta (quinone reductase)
Gene Symbol
CRYZ
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:HPA C Golgi apparatus
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0070402 IDA:UniProtKB F NADPH binding
GO:0003960 IDA:UniProtKB F NADPH:quinone reductase activity
GO:0003730 IDA:UniProtKB F mRNA 3'-UTR binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0051289 IPI:UniProtKB P protein homotetramerization
GO:0007601 TAS:ProtInc P visual perception
GO:0042178 IDA:UniProtKB P xenobiotic catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site

UniProt Annotations

Entry Information

Gene Name
crystallin, zeta (quinone reductase)
Protein Entry
QOR_HUMAN
UniProt ID
Q08257
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q08257-1; Sequence=Displayed; Name=2; IsoId=Q08257-2; Sequence=VSP_042927, VSP_042928; Note=No experimental confirmation available.; Name=3; IsoId=Q08257-3; Sequence=VSP_046425; Note=No experimental confirmation available.;
Catalytic Activity NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Function Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Subcellular Location Cytoplasm .
Subunit Homotetramer. {ECO
Tissue Specificity Only very low amounts in the lens.

Identical and Related Proteins

Unique RefSeq proteins for LMP003948 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13236495 RefSeq NP_001880 329 quinone oxidoreductase isoform a
197927207 RefSeq NP_001128231 192 quinone oxidoreductase isoform c

Identical Sequences to LMP003948 proteins

Reference Database Accession Length Protein Name
GI:197927207 EMBL CAI46072.1 192 hypothetical protein [Homo sapiens]
GI:197927207 GenBank EAX06409.1 192 crystallin, zeta (quinone reductase), isoform CRA_a [Homo sapiens]
GI:197927207 GenBank ADA20373.1 192 Sequence 2197 from patent US 7608413
GI:13236495 GenBank AEN36265.1 329 Sequence 2193 from patent US 7998689
GI:13236495 GenBank AEN36266.1 329 Sequence 2194 from patent US 7998689
GI:13236495 GenBank AEN36267.1 329 Sequence 2195 from patent US 7998689
GI:13236495 GenBank AEN36268.1 329 Sequence 2196 from patent US 7998689
GI:197927207 GenBank AEN36269.1 192 Sequence 2197 from patent US 7998689
GI:13236495 GenBank AEW41276.1 329 Sequence 23 from patent US 8076089
GI:13236495 GenBank AHD78367.1 329 Sequence 26365 from patent US 8586006
GI:197927207 RefSeq XP_005270548.1 192 PREDICTED: quinone oxidoreductase isoform X1 [Homo sapiens]

Related Sequences to LMP003948 proteins

Reference Database Accession Length Protein Name
GI:13236495 DBBJ BAD92951.1 331 crystallin, zeta variant, partial [Homo sapiens]
GI:13236495 DBBJ BAD96870.1 329 crystallin, zeta variant, partial [Homo sapiens]
GI:13236495 DBBJ BAD96921.1 329 crystallin, zeta variant, partial [Homo sapiens]
GI:13236495 DBBJ BAI47298.1 329 crystallin, zeta, partial [synthetic construct]
GI:197927207 GenBank ACR86126.1 329 Sequence 685 from patent US 7521195
GI:197927207 GenBank ACR86128.1 329 Sequence 687 from patent US 7521195
GI:197927207 GenBank ACR86129.1 329 Sequence 688 from patent US 7521195
GI:197927207 GenBank AHD78367.1 329 Sequence 26365 from patent US 8586006
GI:13236495 PDB 1YB5 351 Chain A, Crystal Structure Of Human Zeta-crystallin With Bound Nadp
GI:13236495 PDB 1YB5 351 Chain B, Crystal Structure Of Human Zeta-crystallin With Bound Nadp
GI:197927207 RefSeq XP_009421814.1 192 PREDICTED: quinone oxidoreductase isoform X2 [Pan troglodytes]
GI:197927207 SwissProt Q08257.1 329 RecName: Full=Quinone oxidoreductase; AltName: Full=NADPH:quinone reductase; AltName: Full=Zeta-crystallin [Homo sapiens]