Gene/Proteome Database (LMPD)

LMPD ID
LMP003954
Gene ID
10196
Species
Homo sapiens (Human)
Gene Name
protein arginine methyltransferase 3
Gene Symbol
PRMT3
Synonyms
HRMT1L3
Alternate Names
protein arginine N-methyltransferase 3; HMT1 hnRNP methyltransferase-like 3; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Chromosome
11
Map Location
11p15.1
EC Number
2.1.1.-
Summary
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Orthologs
View orthologs and multiple alignments for PRMT3

Proteins

protein arginine N-methyltransferase 3 isoform 1
Refseq ID NP_005779
Protein GI 44771198
UniProt ID O60678
mRNA ID NM_005788
Length 531
RefSeq Status VALIDATED
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
protein arginine N-methyltransferase 3 isoform 2
Refseq ID NP_001138638
Protein GI 223556008
UniProt ID Q8WUV3
mRNA ID NM_001145166
Length 469
RefSeq Status VALIDATED
MCSLASGATGYSHLLKKHFHTVSLSISLILTAWFINMNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
protein arginine N-methyltransferase 3 isoform 3
Refseq ID NP_001138639
Protein GI 223556010
UniProt ID Q8WUV3
mRNA ID NM_001145167
Length 454
RefSeq Status VALIDATED
MVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ

Gene Information

Entrez Gene ID
10196
Gene Name
protein arginine methyltransferase 3
Gene Symbol
PRMT3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 NAS:UniProtKB C cytoplasm
GO:0005829 IBA:RefGenome C cytosol
GO:0005840 IEA:Ensembl C ribosome
GO:0008469 IBA:RefGenome F histone-arginine N-methyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0008168 IDA:UniProtKB F methyltransferase activity
GO:0072341 IEA:Ensembl F modified amino acid binding
GO:0016274 NAS:UniProtKB F protein-arginine N-methyltransferase activity
GO:0035242 IBA:RefGenome F protein-arginine omega-N asymmetric methyltransferase activity
GO:0034969 IBA:RefGenome P histone arginine methylation
GO:0031397 IDA:UniProtKB P negative regulation of protein ubiquitination
GO:0019919 IBA:RefGenome P peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0006355 IBA:RefGenome P regulation of transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR025799 Protein arginine N-methyltransferase
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

UniProt Annotations

Entry Information

Gene Name
protein arginine methyltransferase 3
Protein Entry
Q8WUV3_HUMAN
UniProt ID
Q8WUV3
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60678-1; Sequence=Displayed; Name=2; IsoId=O60678-2; Sequence=VSP_040330; Note=No experimental confirmation available.;
Domain The zinc-finger is responsible for substrate specificity.
Enzyme Regulation Inhibited by N-ethylmaleimide and high concentrations of zinc chloride.
Function Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
Interaction Q14524:SCN5A; NbExp=2; IntAct=EBI-2809009, EBI-726858;
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family.
Similarity Contains 1 C2H2-type zinc finger.
Similarity Contains 1 SAM-dependent MTase PRMT-type domain.
Subcellular Location Cytoplasm.
Subunit Monomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target proteins. Interacts with the 40S ribosomal protein RPS2. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP003954 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
44771198 RefSeq NP_005779 531 protein arginine N-methyltransferase 3 isoform 1
223556008 RefSeq NP_001138638 469 protein arginine N-methyltransferase 3 isoform 2
223556010 RefSeq NP_001138639 454 protein arginine N-methyltransferase 3 isoform 3

Identical Sequences to LMP003954 proteins

Reference Database Accession Length Protein Name
GI:44771198 DBBJ BAJ20934.1 531 protein arginine methyltransferase 3, partial [synthetic construct]
GI:44771198 GenBank AAH37544.1 531 Protein arginine methyltransferase 3 [Homo sapiens]
GI:223556010 GenBank EAW68334.1 454 protein arginine methyltransferase 3, isoform CRA_b [Homo sapiens]
GI:44771198 GenBank EAW68335.1 531 protein arginine methyltransferase 3, isoform CRA_c [Homo sapiens]
GI:44771198 GenBank ACE86437.1 531 protein arginine methyltransferase 3 protein, partial [synthetic construct]
GI:44771198 GenBank ACE87112.1 531 protein arginine methyltransferase 3 protein [synthetic construct]
GI:44771198 GenBank AHD72272.1 531 Sequence 7770 from patent US 8586006
GI:223556010 RefSeq XP_008954155.1 454 PREDICTED: protein arginine N-methyltransferase 3 isoform X2 [Pan paniscus]
GI:223556010 RefSeq XP_009458355.1 454 PREDICTED: protein arginine N-methyltransferase 3 isoform X3 [Pan troglodytes]

Related Sequences to LMP003954 proteins

Reference Database Accession Length Protein Name
GI:223556008 DBBJ BAG62289.1 469 unnamed protein product [Homo sapiens]
GI:223556010 DBBJ BAJ20934.1 531 protein arginine methyltransferase 3, partial [synthetic construct]
GI:223556010 GenBank AAC39837.1 512 protein arginine N-methyltransferase 3, partial [Homo sapiens]
GI:223556010 GenBank AAH19339.1 548 PRMT3 protein, partial [Homo sapiens]
GI:223556010 GenBank AAV01043.1 512 Sequence 9 from patent US 6743614
GI:223556010 GenBank AFG96346.1 512 Sequence 9 from patent US 8148124
GI:223556010 GenBank AFQ82093.1 512 Sequence 9 from patent US 8247168
GI:44771198 GenBank JAA02013.1 531 protein arginine methyltransferase 3 [Pan troglodytes]
GI:44771198 GenBank JAA16155.1 531 protein arginine methyltransferase 3 [Pan troglodytes]
GI:44771198 GenBank JAA22914.1 531 protein arginine methyltransferase 3 [Pan troglodytes]
GI:44771198 GenBank JAA35457.1 531 protein arginine methyltransferase 3 [Pan troglodytes]
GI:223556008 RefSeq XP_003254365.1 469 PREDICTED: protein arginine N-methyltransferase 3 isoform 3 [Nomascus leucogenys]
GI:44771198 RefSeq XP_003830506.1 531 PREDICTED: protein arginine N-methyltransferase 3 isoform X1 [Pan paniscus]
GI:223556008 RefSeq XP_005578450.1 517 PREDICTED: protein arginine N-methyltransferase 3 isoform X2 [Macaca fascicularis]
GI:223556008 RefSeq XP_005252787.2 498 PREDICTED: protein arginine N-methyltransferase 3 isoform X1 [Homo sapiens]
GI:223556008 RefSeq XP_008002463.1 498 PREDICTED: protein arginine N-methyltransferase 3 isoform X2 [Chlorocebus sabaeus]
GI:223556008 RefSeq XP_009458354.1 468 PREDICTED: protein arginine N-methyltransferase 3 isoform X2 [Pan troglodytes]
GI:44771198 SwissProt O60678.3 531 RecName: Full=Protein arginine N-methyltransferase 3; AltName: Full=Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 [Homo sapiens]