Gene/Proteome Database (LMPD)
LMPD ID
LMP004074
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA binding domain containing 5
Gene Symbol
Synonyms
-
Chromosome
10
Map Location
10p12.1
Summary
This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Orthologs
Proteins
| acyl-CoA-binding domain-containing protein 5 isoform 1 | |
|---|---|
| Refseq ID | NP_663736 |
| Protein GI | 203098629 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_145698 |
| Length | 525 |
| RefSeq Status | REVIEWED |
| MLFLSFHAGSWESWCCCCLIPADRPWDRGQHWQLEMADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN | |
| acyl-CoA-binding domain-containing protein 5 isoform 2 | |
|---|---|
| Refseq ID | NP_001035938 |
| Protein GI | 109689720 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_001042473 |
| Length | 490 |
| RefSeq Status | REVIEWED |
| MADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN | |
| acyl-CoA-binding domain-containing protein 5 isoform 3 | |
|---|---|
| Refseq ID | NP_001258441 |
| Protein GI | 407970996 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_001271512 |
| Length | 523 |
| RefSeq Status | REVIEWED |
| MFQFHAGSWESWCCCCLIPADRPWDRGQHWQLEMADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN | |
| acyl-CoA-binding domain-containing protein 5 isoform 4 | |
|---|---|
| Refseq ID | NP_001288182 |
| Protein GI | 669173520 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_001301253 |
| Length | 416 |
| RefSeq Status | REVIEWED |
| MTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN | |
| acyl-CoA-binding domain-containing protein 5 isoform 4 | |
|---|---|
| Refseq ID | NP_001288181 |
| Protein GI | 669173524 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_001301252 |
| Length | 416 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:669173520 (mRNA isoform) | |
| acyl-CoA-binding domain-containing protein 5 isoform 4 | |
|---|---|
| Refseq ID | NP_001288180 |
| Protein GI | 669173526 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_001301251 |
| Length | 416 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:669173520 (mRNA isoform) | |
| acyl-CoA-binding domain-containing protein 5 isoform 5 | |
|---|---|
| Refseq ID | NP_001288183 |
| Protein GI | 669173522 |
| UniProt ID | Q8NCM9 |
| mRNA ID | NM_001301254 |
| Length | 348 |
| RefSeq Status | REVIEWED |
| MTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN | |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA binding domain containing 5
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0043231 | IDA:HPA | C | intracellular membrane-bounded organelle |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005634 | IDA:HPA | C | nucleus |
| GO:0005777 | IDA:UniProtKB | C | peroxisome |
| GO:0000062 | IEA:InterPro | F | fatty-acyl-CoA binding |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0030242 | IMP:UniProtKB | P | peroxisome degradation |
| GO:0006810 | IEA:UniProtKB-KW | P | transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
acyl-CoA binding domain containing 5
Protein Entry
B7Z2A7_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5T8D3-1; Sequence=Displayed; Name=2; IsoId=Q5T8D3-2; Sequence=VSP_025447, VSP_025449; Note=Contains a phosphothreonine at position 137.; Name=3; IsoId=Q5T8D3-3; Sequence=VSP_025446, VSP_025449; Note=Contains a phosphothreonine at position 172.; Name=4; IsoId=Q5T8D3-4; Sequence=VSP_025448, VSP_025449; Note=Contains a phosphothreonine at position 63.; |
| Function | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. |
| Sequence Caution | Sequence=AAH30555.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the ATG37 family. |
| Similarity | Contains 1 ACB (acyl-CoA-binding) domain. |
| Subcellular Location | Peroxisome membrane ; Single- pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP004074 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 203098629 | RefSeq | NP_663736 | 525 | acyl-CoA-binding domain-containing protein 5 isoform 1 |
| 109689720 | RefSeq | NP_001035938 | 490 | acyl-CoA-binding domain-containing protein 5 isoform 2 |
| 407970996 | RefSeq | NP_001258441 | 523 | acyl-CoA-binding domain-containing protein 5 isoform 3 |
| 669173520 | RefSeq | NP_001288182 | 416 | acyl-CoA-binding domain-containing protein 5 isoform 4 |
| 669173522 | RefSeq | NP_001288183 | 348 | acyl-CoA-binding domain-containing protein 5 isoform 5 |
Identical Sequences to LMP004074 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:109689720 | DBBJ | BAG51918.1 | 490 | unnamed protein product [Homo sapiens] |
| GI:669173522 | DBBJ | BAH11793.1 | 348 | unnamed protein product [Homo sapiens] |
| GI:407970996 | DBBJ | BAH11953.1 | 523 | unnamed protein product [Homo sapiens] |
| GI:669173520 | DBBJ | BAI45263.1 | 416 | acyl-Coenzyme A binding domain containing protein 5, partial [synthetic construct] |
| GI:203098629 | GenBank | EAW86060.1 | 525 | acyl-Coenzyme A binding domain containing 5, isoform CRA_b [Homo sapiens] |
| GI:669173520 | GenBank | EAW86063.1 | 416 | acyl-Coenzyme A binding domain containing 5, isoform CRA_c [Homo sapiens] |
| GI:109689720 | GenBank | ADQ32840.1 | 490 | acyl-Coenzyme A binding domain containing 5, partial [synthetic construct] |
| GI:203098629 | GenBank | JAA10364.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:203098629 | GenBank | JAA23787.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:203098629 | GenBank | JAA35311.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:109689720 | GenBank | AHD76081.1 | 490 | Sequence 19354 from patent US 8586006 |
| GI:109689720 | GenBank | AIC57464.1 | 490 | ACBD5, partial [synthetic construct] |
| GI:203098629 | RefSeq | XP_003312543.1 | 525 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Pan troglodytes] |
| GI:109689720 | RefSeq | XP_507712.3 | 490 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X6 [Pan troglodytes] |
| GI:669173520 | RefSeq | XP_003312544.1 | 416 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X10 [Pan troglodytes] |
| GI:203098629 | RefSeq | XP_003821472.1 | 525 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Pan paniscus] |
| GI:109689720 | RefSeq | XP_003821473.1 | 490 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X6 [Pan paniscus] |
| GI:669173520 | RefSeq | NP_001288181.1 | 416 | acyl-CoA-binding domain-containing protein 5 isoform 4 [Homo sapiens] |
| GI:669173520 | RefSeq | NP_001288180.1 | 416 | acyl-CoA-binding domain-containing protein 5 isoform 4 [Homo sapiens] |
| GI:669173520 | RefSeq | XP_009456417.1 | 416 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X10 [Pan troglodytes] |
| GI:669173522 | RefSeq | XP_009456418.1 | 348 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X11 [Pan troglodytes] |
Related Sequences to LMP004074 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:669173520 | DBBJ | BAC02705.1 | 437 | KIAA1996 protein, partial [Homo sapiens] |
| GI:203098629 | DBBJ | BAH11953.1 | 523 | unnamed protein product [Homo sapiens] |
| GI:669173520 | GenBank | AAH30555.1 | 490 | Acyl-Coenzyme A binding domain containing 5 [Homo sapiens] |
| GI:669173520 | GenBank | ABE15645.1 | 490 | Sequence 3167 from patent US 6979557 |
| GI:669173520 | GenBank | EAW86062.1 | 490 | acyl-Coenzyme A binding domain containing 5, isoform CRA_d [Homo sapiens] |
| GI:669173520 | GenBank | ADQ32840.1 | 490 | acyl-Coenzyme A binding domain containing 5, partial [synthetic construct] |
| GI:109689720 | GenBank | JAA10364.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:407970996 | GenBank | JAA10364.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:203098629 | GenBank | JAA14716.1 | 548 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:407970996 | GenBank | JAA23787.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:109689720 | GenBank | JAA23787.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:407970996 | GenBank | JAA35311.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:109689720 | GenBank | JAA35311.1 | 525 | acyl-CoA binding domain containing 5 [Pan troglodytes] |
| GI:669173520 | GenBank | AIC57464.1 | 490 | ACBD5, partial [synthetic construct] |
| GI:109689720 | RefSeq | NP_663736.2 | 525 | acyl-CoA-binding domain-containing protein 5 isoform 1 [Homo sapiens] |
| GI:407970996 | RefSeq | NP_663736.2 | 525 | acyl-CoA-binding domain-containing protein 5 isoform 1 [Homo sapiens] |
| GI:407970996 | RefSeq | XP_003312543.1 | 525 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Pan troglodytes] |
| GI:109689720 | RefSeq | XP_003312543.1 | 525 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Pan troglodytes] |
| GI:407970996 | RefSeq | XP_003821472.1 | 525 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Pan paniscus] |
| GI:109689720 | RefSeq | XP_003821472.1 | 525 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Pan paniscus] |
| GI:203098629 | RefSeq | NP_001258441.1 | 523 | acyl-CoA-binding domain-containing protein 5 isoform 3 [Homo sapiens] |
| GI:669173522 | RefSeq | XP_004049250.1 | 348 | PREDICTED: acyl-CoA-binding domain-containing protein 5 [Gorilla gorilla gorilla] |
| GI:203098629 | RefSeq | XP_006717594.1 | 536 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X4 [Homo sapiens] |
| GI:669173522 | RefSeq | XP_006717596.1 | 532 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X6 [Homo sapiens] |
| GI:669173522 | RefSeq | XP_006717597.1 | 521 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X7 [Homo sapiens] |
| GI:669173522 | RefSeq | XP_008000820.1 | 457 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X6 [Chlorocebus sabaeus] |
| GI:203098629 | RefSeq | XP_008973140.1 | 536 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X2 [Pan paniscus] |
| GI:203098629 | RefSeq | XP_009456410.1 | 536 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X2 [Pan troglodytes] |
| GI:669173522 | RefSeq | XP_009456414.1 | 475 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X7 [Pan troglodytes] |
| GI:669173522 | RefSeq | XP_009456415.1 | 464 | PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X8 [Pan troglodytes] |