Gene/Proteome Database (LMPD)

LMPD ID
LMP004088
Gene ID
64768
Species
Homo sapiens (Human)
Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Gene Symbol
IPPK
Synonyms
C9orf12; INSP5K2; IP5K; IPK1; bA476B13.1
Alternate Names
inositol-pentakisphosphate 2-kinase; IPK1 homolog; insP5 2-kinase; ins(1,3,4,5,6)P5 2-kinase; bA476B13.1 (novel protein)
Chromosome
9
Map Location
9q22.31
EC Number
2.7.1.158
Summary
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
Orthologs
View orthologs and multiple alignments for IPPK

Proteins

inositol-pentakisphosphate 2-kinase
Refseq ID NP_073592
Protein GI 12232423
UniProt ID Q9H8X2
mRNA ID NM_022755
Length 491
RefSeq Status REVIEWED
MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV

Gene Information

Entrez Gene ID
64768
Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Gene Symbol
IPPK
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005622 IDA:BHF-UCL C intracellular
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035299 IDA:HGNC F inositol pentakisphosphate 2-kinase activity
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0052746 IDA:BHF-UCL P inositol phosphorylation
GO:0044281 TAS:Reactome P small molecule metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
PWY-6369 inositol pyrophosphates biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150275 Synthesis of IPs in the nucleus
REACT_150188 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR009286 Inositol-pentakisphosphate 2-kinase

UniProt Annotations

Entry Information

Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein Entry
IPPK_HUMAN
UniProt ID
Q9H8X2
Species
Human

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.43 uM for Ins(1,3,4,5,6)P5 ; KM=21 uM for ATP ; Vmax=31 nmol/min/mg enzyme ;
Catalytic Activity ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.
Domain The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO
Sequence Caution Sequence=BAB14866.1; Type=Erroneous initiation; Evidence= ; Sequence=CAI12593.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the IPK1 type 2 family.
Subcellular Location Cytoplasm . Nucleus .
Tissue Specificity Ubiquitously expressed, with high expression in heart, brain, testis and placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP004088 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12232423 RefSeq NP_073592 491 inositol-pentakisphosphate 2-kinase

Identical Sequences to LMP004088 proteins

Reference Database Accession Length Protein Name
GI:12232423 EMBL CAE91701.1 491 unnamed protein product [Homo sapiens]
GI:12232423 GenBank AAH26154.1 491 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Homo sapiens]
GI:12232423 GenBank AAM75353.1 491 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Homo sapiens]
GI:12232423 GenBank EAW62826.1 491 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Homo sapiens]
GI:12232423 GenBank AIC52150.1 491 IPPK, partial [synthetic construct]
GI:12232423 SwissProt Q9H8X2.1 491 RecName: Full=Inositol-pentakisphosphate 2-kinase; AltName: Full=IPK1 homolog; AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; AltName: Full=Ins(1,3,4,5,6)P5 2-kinase; Short=InsP5 2-kinase [Homo sapiens]

Related Sequences to LMP004088 proteins

Reference Database Accession Length Protein Name
GI:12232423 GenBank JAA05245.1 491 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Pan troglodytes]
GI:12232423 GenBank JAA18436.1 491 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Pan troglodytes]
GI:12232423 GenBank JAA25448.1 491 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Pan troglodytes]
GI:12232423 GenBank JAA36683.1 491 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Pan troglodytes]
GI:12232423 RefSeq XP_001146962.1 491 PREDICTED: inositol-pentakisphosphate 2-kinase [Pan troglodytes]
GI:12232423 RefSeq XP_004048311.1 491 PREDICTED: inositol-pentakisphosphate 2-kinase [Gorilla gorilla gorilla]