Gene/Proteome Database (LMPD)
Proteins
serum paraoxonase/lactonase 3 precursor | |
---|---|
Refseq ID | NP_766594 |
Protein GI | 27370510 |
UniProt ID | Q62087 |
mRNA ID | NM_173006 |
Length | 354 |
RefSeq Status | PROVISIONAL |
MGKLVALTLLGACLALIGERLLNFRERVSTTREIKATEPQNCHLIEGLENGSEDIDILPSGLAFISTGLKYPGMPAFAPDKPGRIFLMDLNEQNPEAQALEISGGLDQESLNPHGISTFIDKDNTAYLYVVNHPNMDSTVEIFKFEEQQRSLIHLKTLKHELLKSVNDIVVLGPEQFYATRDHYFTSYFLVLLEMILDPHWTSVVFYSPKEVKVVAQGFSSANGITVSLDQKFVYVADVTAKNIHIMKKHDNWDLTPVKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLIYNPEDPPGSEVLRIQDSLSDKPRVSTLYANNGSVLQGSTVASVYHKRMLIGTIFHKALYCDL | |
sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1474 peptide sequence: MGKLVALTLLGACLA |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005615 | IEA:Ensembl | C | extracellular space |
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0043231 | IEA:Ensembl | C | intracellular membrane-bounded organelle |
GO:0018733 | IEA:Ensembl | F | 3,4-dihydrocoumarin hydrolase activity |
GO:0004063 | IEA:UniProtKB-EC | F | aryldialkylphosphatase activity |
GO:0004064 | IEA:UniProtKB-EC | F | arylesterase activity |
GO:0047856 | IEA:Ensembl | F | dihydrocoumarin hydrolase activity |
GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
GO:0046226 | IEA:Ensembl | P | coumarin catabolic process |
GO:0010124 | IEA:Ensembl | P | phenylacetate catabolic process |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
mmu01100 | Metabolic pathways |
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | A phenyl acetate + H(2)O = a phenol + acetate. {ECO:0000269|PubMed:15963993}. |
Catalytic Activity | An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. {ECO:0000269|PubMed:15963993}. |
Catalytic Activity | An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. {ECO:0000269|PubMed:15963993}. |
Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250}; |
Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity). {ECO:0000250}. |
Ptm | Glycosylated. {ECO:0000250}. |
Ptm | The signal sequence is not cleaved. {ECO:0000250}. |
Similarity | Belongs to the paraoxonase family. {ECO:0000305}. |
Subcellular Location | Secreted, extracellular space {ECO:0000250}. |
Subunit | Homodimer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004092 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
27370510 | RefSeq | NP_766594 | 354 | serum paraoxonase/lactonase 3 precursor |
Identical Sequences to LMP004092 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:27370510 | DBBJ | BAC40430.1 | 354 | unnamed protein product [Mus musculus] |
GI:27370510 | GenBank | AAH99416.1 | 354 | Paraoxonase 3 [Mus musculus] |
GI:27370510 | GenBank | EDL13970.1 | 354 | paraoxonase 3, isoform CRA_b [Mus musculus] |
GI:27370510 | GenBank | ADL98070.1 | 354 | Sequence 11 from patent US 7718773 |
GI:27370510 | SwissProt | Q62087.2 | 354 | RecName: Full=Serum paraoxonase/lactonase 3 [Mus musculus] |
Related Sequences to LMP004092 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:27370510 | GenBank | AAC42090.1 | 354 | paraoxonase-3 [Mus musculus domesticus] |
GI:27370510 | GenBank | AAQ40645.1 | 354 | Sequence 25 from patent US 6573370 |
GI:27370510 | GenBank | AAH79466.1 | 354 | Paraoxonase 3 [Rattus norvegicus] |
GI:27370510 | GenBank | ABA16082.1 | 354 | Sequence 25 from patent US 6916472 |
GI:27370510 | GenBank | EDM15021.1 | 354 | paraoxonase 3, isoform CRA_b [Rattus norvegicus] |
GI:27370510 | RefSeq | NP_001004086.1 | 354 | serum paraoxonase/lactonase 3 precursor [Rattus norvegicus] |