Gene/Proteome Database (LMPD)

LMPD ID
LMP004092
Gene ID
Species
Mus musculus (Mouse)
Gene Name
paraoxonase 3
Gene Symbol
Synonyms
2810004E20; AI786302
Alternate Names
serum paraoxonase/lactonase 3
Chromosome
6
Map Location
6 A1|6 1.99 cM
EC Number
3.1.1.2

Proteins

serum paraoxonase/lactonase 3 precursor
Refseq ID NP_766594
Protein GI 27370510
UniProt ID Q62087
mRNA ID NM_173006
Length 354
RefSeq Status PROVISIONAL
MGKLVALTLLGACLALIGERLLNFRERVSTTREIKATEPQNCHLIEGLENGSEDIDILPSGLAFISTGLKYPGMPAFAPDKPGRIFLMDLNEQNPEAQALEISGGLDQESLNPHGISTFIDKDNTAYLYVVNHPNMDSTVEIFKFEEQQRSLIHLKTLKHELLKSVNDIVVLGPEQFYATRDHYFTSYFLVLLEMILDPHWTSVVFYSPKEVKVVAQGFSSANGITVSLDQKFVYVADVTAKNIHIMKKHDNWDLTPVKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLIYNPEDPPGSEVLRIQDSLSDKPRVSTLYANNGSVLQGSTVASVYHKRMLIGTIFHKALYCDL
sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1474 peptide sequence: MGKLVALTLLGACLA

Gene Information

Entrez Gene ID
Gene Name
paraoxonase 3
Gene Symbol
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0043231 IEA:Ensembl C intracellular membrane-bounded organelle
GO:0018733 IEA:Ensembl F 3,4-dihydrocoumarin hydrolase activity
GO:0004063 IEA:UniProtKB-EC F aryldialkylphosphatase activity
GO:0004064 IEA:UniProtKB-EC F arylesterase activity
GO:0047856 IEA:Ensembl F dihydrocoumarin hydrolase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046226 IEA:Ensembl P coumarin catabolic process
GO:0010124 IEA:Ensembl P phenylacetate catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002640 Arylesterase
IPR008364 Paraoxonase2
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
paraoxonase 3
Protein Entry
PON3_MOUSE
UniProt ID
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A phenyl acetate + H(2)O = a phenol + acetate. {ECO:0000269|PubMed:15963993}.
Catalytic Activity An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. {ECO:0000269|PubMed:15963993}.
Catalytic Activity An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. {ECO:0000269|PubMed:15963993}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250};
Function Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity). {ECO:0000250}.
Ptm Glycosylated. {ECO:0000250}.
Ptm The signal sequence is not cleaved. {ECO:0000250}.
Similarity Belongs to the paraoxonase family. {ECO:0000305}.
Subcellular Location Secreted, extracellular space {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004092 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27370510 RefSeq NP_766594 354 serum paraoxonase/lactonase 3 precursor

Identical Sequences to LMP004092 proteins

Reference Database Accession Length Protein Name
GI:27370510 DBBJ BAC40430.1 354 unnamed protein product [Mus musculus]
GI:27370510 GenBank AAH99416.1 354 Paraoxonase 3 [Mus musculus]
GI:27370510 GenBank EDL13970.1 354 paraoxonase 3, isoform CRA_b [Mus musculus]
GI:27370510 GenBank ADL98070.1 354 Sequence 11 from patent US 7718773
GI:27370510 SwissProt Q62087.2 354 RecName: Full=Serum paraoxonase/lactonase 3 [Mus musculus]

Related Sequences to LMP004092 proteins

Reference Database Accession Length Protein Name
GI:27370510 GenBank AAC42090.1 354 paraoxonase-3 [Mus musculus domesticus]
GI:27370510 GenBank AAQ40645.1 354 Sequence 25 from patent US 6573370
GI:27370510 GenBank AAH79466.1 354 Paraoxonase 3 [Rattus norvegicus]
GI:27370510 GenBank ABA16082.1 354 Sequence 25 from patent US 6916472
GI:27370510 GenBank EDM15021.1 354 paraoxonase 3, isoform CRA_b [Rattus norvegicus]
GI:27370510 RefSeq NP_001004086.1 354 serum paraoxonase/lactonase 3 precursor [Rattus norvegicus]