Gene/Proteome Database (LMPD)
LMPD ID
LMP004151
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol transfer protein, membrane-associated 1
Gene Symbol
Synonyms
DRES9; Mpt-1; Nir-2; PITPnm 1; Pitpnm; R75447; Rd9; RdgB; RdgB1
Alternate Names
membrane-associated phosphatidylinositol transfer protein 1; retinal degeneration 9; drosophila retinal degeneration B homolog 1; pyk2 N-terminal domain-interacting receptor 2
Chromosome
19
Map Location
19 B1|19 3.81 cM
Proteins
| membrane-associated phosphatidylinositol transfer protein 1 | |
|---|---|
| Refseq ID | NP_032877 |
| Protein GI | 6679339 |
| UniProt ID | O35954 |
| mRNA ID | NM_008851 |
| Length | 1243 |
| RefSeq Status | VALIDATED |
| MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRIVDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQTPGKSSTEARPGTSTAGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGGVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFIDAFASPTEVEGVPDPTVMATKGIEDGARAPRDSEGLDGAGDLVVEACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGTGFCGQVVLIGDGVGGILGFDALCHSASAGPGSRGSSRRGSMNNEMLSPEVGPVRDPLADGVEVLGRASPEPSALPAQRTFSDMANPDPDGSQNSLQVASTATSSGEPRRASTASCPPASSEAPDGPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQLRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGSELGNEPASQTAAPSTTSEVVKILDRWWGNKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLTECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFGTEVTNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHAPSGPPRAALAKSSYAVAAPVDFLRKQSQLLRSRGPSQVDREGPGTPPTTLARGKTRSISLKLDSEE | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol transfer protein, membrane-associated 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005811 | IEA:UniProtKB-KW | C | lipid particle |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0005543 | ISA:MGI | F | phospholipid binding |
| GO:0015031 | IEA:UniProtKB-KW | P | protein transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol transfer protein, membrane-associated 1
Protein Entry
PITM1_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Detected at low levels during fetal development up to day 15. Highly expressed at day 17. |
| Function | Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions (By similarity). {ECO:0000250}. |
| Ptm | Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1 (By similarity). {ECO:0000250}. |
| Ptm | Phosphorylated on threonine residues upon treatment with oleic acid. {ECO:0000250}. |
| Ptm | Phosphorylated on tyrosine residues by PTK2B. {ECO:0000250}. |
| Similarity | Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. {ECO:0000305}. |
| Similarity | Contains 1 DDHD domain. {ECO:0000255|PROSITE- ProRule:PRU00378}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (By similarity). {ECO:0000250}. |
| Subunit | Interacts with PTK2B via its C-terminus. Interacts with RHOA. Has higher affinity for the inactive, GDP-bound form of RHOA. The CDK1-phosphorylated form interacts with PLK1. Interacts with VAPB and PIK4CA (By similarity). {ECO:0000250}. |
| Tissue Specificity | Detected at high levels in brain, and at lower levels in lung, kidney, spleen and liver (at protein level). Ubiquitous. Highly expressed in embryonic retina and the central nervous system. {ECO:0000269|PubMed:9245688, ECO:0000269|PubMed:9680295}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004151 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6679339 | RefSeq | NP_032877 | 1243 | membrane-associated phosphatidylinositol transfer protein 1 |
Identical Sequences to LMP004151 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6679339 | GenBank | AAB84393.1 | 1243 | membrane-associated phosphatidylinositol transfer protein [Mus musculus] |
| GI:6679339 | GenBank | AAH44893.1 | 1243 | Phosphatidylinositol transfer protein, membrane-associated 1 [Mus musculus] |
| GI:6679339 | GenBank | AAH48150.1 | 1243 | Phosphatidylinositol transfer protein, membrane-associated 1 [Mus musculus] |
| GI:6679339 | GenBank | EDL33005.1 | 1243 | phosphatidylinositol membrane-associated 1, isoform CRA_a [Mus musculus] |
| GI:6679339 | GenBank | EDL33006.1 | 1243 | phosphatidylinositol membrane-associated 1, isoform CRA_a [Mus musculus] |
| GI:6679339 | SwissProt | O35954.1 | 1243 | RecName: Full=Membrane-associated phosphatidylinositol transfer protein 1; AltName: Full=Drosophila retinal degeneration B homolog 1; Short=RdgB1; AltName: Full=Mpt-1; AltName: Full=Phosphatidylinositol transfer protein, membrane-associated 1; Short=PITPnm 1; AltName: Full=Pyk2 N-terminal domain-interacting receptor 2; Short=NIR-2 [Mus musculus] |
Related Sequences to LMP004151 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6679339 | GenBank | AAH85945.1 | 1242 | Phosphatidylinositol transfer protein, membrane-associated 1 [Rattus norvegicus] |
| GI:6679339 | GenBank | EDM12363.1 | 1242 | phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a [Rattus norvegicus] |
| GI:6679339 | GenBank | EDM12364.1 | 1242 | phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a [Rattus norvegicus] |
| GI:6679339 | RefSeq | NP_001008370.1 | 1242 | membrane-associated phosphatidylinositol transfer protein 1 [Rattus norvegicus] |
| GI:6679339 | RefSeq | XP_006980594.1 | 1244 | PREDICTED: membrane-associated phosphatidylinositol transfer protein 1 [Peromyscus maniculatus bairdii] |
| GI:6679339 | SwissProt | Q5U2N3.1 | 1242 | RecName: Full=Membrane-associated phosphatidylinositol transfer protein 1; AltName: Full=Phosphatidylinositol transfer protein, membrane-associated 1; Short=PITPnm 1; AltName: Full=Pyk2 N-terminal domain-interacting receptor 2; Short=NIR-2 [Rattus norvegicus] |