Gene/Proteome Database (LMPD)
LMPD ID
LMP004199
Gene ID
Species
Mus musculus (Mouse)
Gene Name
solute carrier family 27 (fatty acid transporter), member 4
Gene Symbol
Synonyms
BB144259; FATP4
Alternate Names
long-chain fatty acid transport protein 4; FATP-4; fatty acid transport protein 4; solute carrier family 27 member 4
Chromosome
2
Map Location
2 B|2 20.64 cM
EC Number
6.2.1.-
Proteins
| long-chain fatty acid transport protein 4 | |
|---|---|
| Refseq ID | NP_036119 |
| Protein GI | 45597453 |
| UniProt ID | Q91VE0 |
| mRNA ID | NM_011989 |
| Length | 643 |
| RefSeq Status | PROVISIONAL |
| MLLGASLVGALLFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRVFIKTVRRDIFGGMVLLKVKTKVRRYLQERKTVPLLFASMVQRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGNVVALFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAICEIHASLEPTLSLFCSGSWEPSTVPVSTEHLDPLLEDAPKHLPSHPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMASLVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFYGATECNCSLGNFDSRVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLVGRIIQQDPLRRFDGYLNQGANNKKIANDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLHMADVAVYGVEVPGTEGRAGMAAVASPISNCDLESFAQTLKKELPLYARPIFLRFLPELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARKGCYVALDQEAYTRIQAGEEKL | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier family 27 (fatty acid transporter), member 4
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031526 | IDA:MGI | C | brush border membrane |
| GO:0005783 | IDA:MGI | C | endoplasmic reticulum |
| GO:0005789 | IEA:Ensembl | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005902 | IDA:MGI | C | microvillus |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0004467 | IDA:MGI | F | long-chain fatty acid-CoA ligase activity |
| GO:0000166 | IEA:UniProtKB-KW | F | nucleotide binding |
| GO:0031957 | IDA:MGI | F | very long-chain fatty acid-CoA ligase activity |
| GO:0006631 | IMP:MGI | P | fatty acid metabolic process |
| GO:0044539 | IEA:Ensembl | P | long-chain fatty acid import |
| GO:0001676 | IDA:MGI | P | long-chain fatty acid metabolic process |
| GO:0015909 | IMP:MGI | P | long-chain fatty acid transport |
| GO:0001579 | IDA:MGI | P | medium-chain fatty acid transport |
| GO:0007584 | IEA:Ensembl | P | response to nutrient |
| GO:0043588 | IMP:MGI | P | skin development |
| GO:0042760 | IDA:MGI | P | very long-chain fatty acid catabolic process |
| GO:0000038 | IDA:MGI | P | very long-chain fatty acid metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5893867 | Transport of fatty acids |
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier family 27 (fatty acid transporter), member 4
Protein Entry
S27A4_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Disease | Note=Defects in Slc27a4 are the cause of wrinkle-free (wrfr) phenotype. It is a spontaneous, autosomal recessive mutation resulting in very tight, thick skin and is secondary characterized by severe breathing difficulties. Mice die shortly after birth. This phenotype is similar to human restrictive dermopathy, a very rare human genetic disorder. {ECO:0000269|PubMed:12697906}. |
| Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. {ECO:0000269|PubMed:10518211, ECO:0000269|PubMed:11404000, ECO:0000269|PubMed:12821645, ECO:0000269|PubMed:15653672, ECO:0000269|PubMed:15699031, ECO:0000269|PubMed:23407971}. |
| Miscellaneous | Deletion of Slc27a4 results in embryonic lethality, which has been attributed to a requirement for fat absorption early in embryonic development across the visceral endoderm. |
| Miscellaneous | Slc27a4 deficient mice display features of a neonatally lethal restrictive dermopathy. Their skin is characterized by hyperproliferative hyperkeratosis with a disturbed epidermal barrier, a flat dermal-epidermal junction, a reduced number of pilo-sebaceous structures, and a compact dermis. The rigid skin consistency results in an altered body shape with facial dysmorphia, generalized joint flexion contractures and impaired movement including suckling and breathing deficiencies. Lipid analysis demonstrates a disturbed fatty acid composition of epidermal ceramides, in particular a decrease in the C26:0 and C26:0-OH fatty acid substitutes. |
| Sequence Caution | Sequence=AAC40188.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAC40188.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. |
| Tissue Specificity | Most abundantly expressed in small intestine, brain, kidney, liver, skin and heart. In small intestine, expressed at high levels on the apical side of mature enterocytes. Highly expressed by the epithelial cells of the visceral endoderm and localized to the brush-border membrane of extraembryonic endodermal cells (at protein level). Expressed in the retinal pigment epithelium and in the retina (at protein level). Expressed in the retinal pigment epithelium and in the retina. {ECO:0000269|PubMed:10518211, ECO:0000269|PubMed:11404000, ECO:0000269|PubMed:14512415, ECO:0000269|PubMed:23407971, ECO:0000269|PubMed:9671728}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004199 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 45597453 | RefSeq | NP_036119 | 643 | long-chain fatty acid transport protein 4 |
Identical Sequences to LMP004199 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:45597453 | DBBJ | BAC29639.1 | 643 | unnamed protein product [Mus musculus] |
| GI:45597453 | DBBJ | BAE33236.1 | 643 | unnamed protein product [Mus musculus] |
| GI:45597453 | EMBL | CAJ18520.1 | 643 | Slc27a4 [Mus musculus] |
| GI:45597453 | GenBank | AAH23114.1 | 643 | Solute carrier family 27 (fatty acid transporter), member 4 [Mus musculus] |
| GI:45597453 | GenBank | EDL08422.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4 [Mus musculus] |
| GI:45597453 | SwissProt | Q91VE0.1 | 643 | RecName: Full=Long-chain fatty acid transport protein 4; Short=FATP-4; Short=Fatty acid transport protein 4; AltName: Full=Solute carrier family 27 member 4 [Mus musculus] |
Related Sequences to LMP004199 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:45597453 | DBBJ | BAE41756.1 | 643 | unnamed protein product [Mus musculus] |
| GI:45597453 | GenBank | AAE81545.1 | 643 | Sequence 45 from patent US 6288213 |
| GI:45597453 | GenBank | AAE81558.1 | 643 | Sequence 71 from patent US 6288213 |
| GI:45597453 | GenBank | AAE92220.1 | 643 | Sequence 45 from patent US 6348321 |
| GI:45597453 | GenBank | AAQ80189.1 | 643 | Sequence 45 from patent US 6300096 |
| GI:45597453 | GenBank | ABH70740.1 | 643 | Sequence 45 from patent US 7033772 |