Gene/Proteome Database (LMPD)

LMPD ID
LMP004256
Gene ID
1666
Species
Homo sapiens (Human)
Gene Name
2,4-dienoyl CoA reductase 1, mitochondrial
Gene Symbol
DECR1
Synonyms
DECR; NADPH; SDR18C1
Alternate Names
2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase; short chain dehydrogenase/reductase family 18C, member 1
Chromosome
8
Map Location
8q21.3
EC Number
1.3.1.34
Summary
This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for DECR1

Proteins

2,4-dienoyl-CoA reductase, mitochondrial precursor
Refseq ID NP_001350
Protein GI 4503301
UniProt ID Q16698
mRNA ID NM_001359
Length 335
RefSeq Status REVIEWED
MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
transit_peptide: 1..34 calculated_mol_wt: 3936 peptide sequence: MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQ mat_peptide: 35..335 product: 2,4-dienoyl-CoA reductase, mitochondrial calculated_mol_wt: 32150 peptide sequence: NTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS

Gene Information

Entrez Gene ID
1666
Gene Name
2,4-dienoyl CoA reductase 1, mitochondrial
Gene Symbol
DECR1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005759 TAS:Reactome C mitochondrial matrix
GO:0005739 NAS:UniProtKB C mitochondrion
GO:0005634 IDA:UniProt C nucleus
GO:0008670 IDA:UniProtKB F 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0070402 IDA:UniProtKB F NADPH binding
GO:0016651 TAS:Reactome F oxidoreductase activity, acting on NAD(P)H
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0006635 IDA:UniProtKB P fatty acid beta-oxidation
GO:0051289 IDA:UniProtKB P protein homotetramerization
GO:0044281 TAS:Reactome P small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_1473 Mitochondrial Fatty Acid Beta-Oxidation
REACT_160 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
2,4-dienoyl CoA reductase 1, mitochondrial
Protein Entry
DECR_HUMAN
UniProt ID
Q16698
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16698-1; Sequence=Displayed; Name=2; IsoId=Q16698-2; Sequence=VSP_056388; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=7.7 uM for NADPH ; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA ; Vmax=30.3 umol/min/mg enzyme ;
Catalytic Activity Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
Function Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Subcellular Location Mitochondrion.
Subunit Homotetramer.
Tissue Specificity Heart = liver = pancreas > kidney >> skeletal muscle = lung.

Identical and Related Proteins

Unique RefSeq proteins for LMP004256 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4503301 RefSeq NP_001350 335 2,4-dienoyl-CoA reductase, mitochondrial precursor

Identical Sequences to LMP004256 proteins

Reference Database Accession Length Protein Name
GI:4503301 GenBank EAW91663.1 335 2,4-dienoyl CoA reductase 1, mitochondrial, isoform CRA_b [Homo sapiens]
GI:4503301 GenBank EAW91664.1 335 2,4-dienoyl CoA reductase 1, mitochondrial, isoform CRA_b [Homo sapiens]
GI:4503301 GenBank AHD74235.1 335 Sequence 13601 from patent US 8586006
GI:4503301 GenBank AIC48630.1 335 DECR1, partial [synthetic construct]
GI:4503301 RefSeq XP_003821191.1 335 PREDICTED: 2,4-dienoyl-CoA reductase, mitochondrial isoform X1 [Pan paniscus]
GI:4503301 RefSeq XP_004047307.1 335 PREDICTED: 2,4-dienoyl-CoA reductase, mitochondrial isoform 1 [Gorilla gorilla gorilla]

Related Sequences to LMP004256 proteins

Reference Database Accession Length Protein Name
GI:4503301 GenBank ACM84498.1 367 Sequence 9996 from patent US 6812339
GI:4503301 GenBank JAA00771.1 335 2,4-dienoyl CoA reductase 1, mitochondrial [Pan troglodytes]
GI:4503301 GenBank JAA11601.1 335 2,4-dienoyl CoA reductase 1, mitochondrial [Pan troglodytes]
GI:4503301 GenBank JAA30469.1 335 2,4-dienoyl CoA reductase 1, mitochondrial [Pan troglodytes]
GI:4503301 GenBank JAA40517.1 335 2,4-dienoyl CoA reductase 1, mitochondrial [Pan troglodytes]
GI:4503301 RefSeq XP_001138969.1 335 PREDICTED: 2,4-dienoyl-CoA reductase, mitochondrial [Pan troglodytes]