Gene/Proteome Database (LMPD)

LMPD ID
LMP004290
Gene ID
84188
Species
Homo sapiens (Human)
Gene Name
fatty acyl CoA reductase 1
Gene Symbol
FAR1
Synonyms
MLSTD2; SDR10E1
Alternate Names
fatty acyl-CoA reductase 1; putative fatty acyl reductase; male sterility domain containing 2; male sterility domain-containing protein 2; short chain dehydrogenase/reductase family 10E, member 1
Chromosome
11
Map Location
11p15.2
EC Number
1.2.1.n2

Proteins

fatty acyl-CoA reductase 1
Refseq ID NP_115604
Protein GI 24308324
UniProt ID Q8WVX9
mRNA ID NM_032228
Length 515
RefSeq Status VALIDATED
MVSIPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY

Gene Information

Entrez Gene ID
84188
Gene Name
fatty acyl CoA reductase 1
Gene Symbol
FAR1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005782 TAS:Reactome C peroxisomal matrix
GO:0005778 IDA:UniProtKB C peroxisomal membrane
GO:0005777 IDA:UniProtKB C peroxisome
GO:0080019 IDA:UniProtKB F fatty-acyl-CoA reductase (alcohol-forming) activity
GO:0050062 IEA:Ensembl F long-chain-fatty-acyl-CoA reductase activity
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0008611 IMP:UniProtKB P ether lipid biosynthetic process
GO:0046474 IDA:UniProtKB P glycerophospholipid biosynthetic process
GO:0035336 IDA:UniProtKB P long-chain fatty-acyl-CoA metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0010025 IEA:Ensembl P wax biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04146 Peroxisome
ko04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_16957 Peroxisomal lipid metabolism
REACT_1407 Plasmalogen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR026055 Fatty acyl-CoA reductase
IPR013120 Male sterility, NAD-binding
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acyl CoA reductase 1
Protein Entry
FACR1_HUMAN
UniProt ID
Q8WVX9
Species
Human

Comments

Comment Type Description
Catalytic Activity Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
Function Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols.
Interaction Q9BUV8:C20orf24; NbExp=1; IntAct=EBI-1045879, EBI-1050079;
Similarity Belongs to the fatty acyl-CoA reductase family.
Subcellular Location Peroxisome membrane ; Single-pass membrane protein .
Subunit Interacts (via C-terminus) with PEX19, the interaction is required for targeting to peroxisomes.

Identical and Related Proteins

Unique RefSeq proteins for LMP004290 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24308324 RefSeq NP_115604 515 fatty acyl-CoA reductase 1

Identical Sequences to LMP004290 proteins

Reference Database Accession Length Protein Name
GI:24308324 GenBank ACJ96294.1 515 Sequence 4 from patent US 7417116
GI:24308324 GenBank ACK04074.1 515 Sequence 4 from patent US 7429641
GI:24308324 GenBank ACK27781.1 515 Sequence 4 from patent US 7456261
GI:24308324 GenBank ACN00164.1 515 Sequence 4 from patent US 7476723
GI:24308324 GenBank ADS26158.1 515 Sequence 4 from patent US 7777007
GI:24308324 GenBank ADS58539.1 515 Sequence 4 from patent US 7807385

Related Sequences to LMP004290 proteins

Reference Database Accession Length Protein Name
GI:24308324 GenBank JAA04188.1 515 fatty acyl CoA reductase 1 [Pan troglodytes]
GI:24308324 GenBank JAA14513.1 515 fatty acyl CoA reductase 1 [Pan troglodytes]
GI:24308324 RefSeq XP_001171908.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X2 [Pan troglodytes]
GI:24308324 RefSeq XP_003255016.1 515 PREDICTED: fatty acyl-CoA reductase 1 [Nomascus leucogenys]
GI:24308324 RefSeq XP_004050782.1 515 PREDICTED: fatty acyl-CoA reductase 1 [Gorilla gorilla gorilla]
GI:24308324 RefSeq XP_008969698.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X1 [Pan paniscus]