Gene/Proteome Database (LMPD)

LMPD ID
LMP004300
Gene ID
12623
Species
Mus musculus (Mouse)
Gene Name
carboxylesterase 1G
Gene Symbol
Ces1g
Synonyms
Ces-1; Ces1; Ses-1
Chromosome
8
Map Location
8 C5|8 45.29 cM
Summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Orthologs
View orthologs and multiple alignments for Ces1g

Proteins

liver carboxylesterase 1 precursor
Refseq ID NP_067431
Protein GI 162287349
UniProt ID Q3UW56
mRNA ID NM_021456
Length 565
RefSeq Status REVIEWED
MWLCALSLISLTACLSLGHPSLPPVVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVIDGASTYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPSVIVSRSHRDAGAPTYMYEYQYRPSFVSDDRPQELLGDHADELFSVWGAPFLKEGASEEEINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGVPAQAAHRLKDKEVDFWTELRAKETAERSSHREHVEL
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1895 peptide sequence: MWLCALSLISLTACLSLG mat_peptide: 19..565 product: liver carboxylesterase 1 calculated_mol_wt: 60803 peptide sequence: HPSLPPVVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVIDGASTYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPSVIVSRSHRDAGAPTYMYEYQYRPSFVSDDRPQELLGDHADELFSVWGAPFLKEGASEEEINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGVPAQAAHRLKDKEVDFWTELRAKETAERSSHREHVEL

Gene Information

Entrez Gene ID
12623
Gene Name
carboxylesterase 1G
Gene Symbol
Ces1g
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0052689 IBA:RefGenome F carboxylic ester hydrolase activity
GO:0008152 IBA:GOC P metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR019826 Carboxylesterase type B, active site
IPR019819 Carboxylesterase type B, conserved site
IPR002018 Carboxylesterase, type B

UniProt Annotations

Entry Information

Gene Name
carboxylesterase 1G
Protein Entry
EST1_MOUSE
UniProt ID
Q3UW56
Species
Mouse

Identical and Related Proteins

Unique RefSeq proteins for LMP004300 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
162287349 RefSeq NP_067431 565 liver carboxylesterase 1 precursor

Identical Sequences to LMP004300 proteins

Reference Database Accession Length Protein Name
GI:162287349 DBBJ BAE28882.1 565 unnamed protein product [Mus musculus]
GI:162287349 DBBJ BAE36856.1 565 unnamed protein product [Mus musculus]
GI:162287349 DBBJ BAE22982.1 565 unnamed protein product [Mus musculus]
GI:162287349 DBBJ BAE23063.1 565 unnamed protein product [Mus musculus]
GI:162287349 GenBank ABW58346.1 565 Sequence 3 from patent US 7273717
GI:162287349 SwissProt Q8VCC2.1 565 RecName: Full=Liver carboxylesterase 1; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase; AltName: Full=Carboxylesterase 1G; AltName: Full=ES-x; Flags: Precursor [Mus musculus]

Related Sequences to LMP004300 proteins

Reference Database Accession Length Protein Name
GI:162287349 EMBL CAA73388.1 565 carboxylesterase [Mus musculus]
GI:162287349 GenBank EDL11099.1 566 mCG9581 [Mus musculus]
GI:162287349 GenBank ABW58347.1 547 Sequence 4 from patent US 7273717
GI:162287349 GenBank AGD76151.1 565 Sequence 76 from patent US 8349555
GI:162287349 RefSeq XP_003511207.2 566 PREDICTED: liver carboxylesterase 1 [Cricetulus griseus]
GI:162287349 RefSeq XP_007610405.1 566 PREDICTED: liver carboxylesterase 1 [Cricetulus griseus]