Gene/Proteome Database (LMPD)
LMPD ID
LMP004304
Gene ID
Species
Mus musculus (Mouse)
Gene Name
protein disulfide isomerase associated 3
Gene Symbol
Synonyms
58kDa; ERp57; ERp60; ERp61; Erp; Grp58; PDI; PDI-Q2; PI-PLC; PLC[a]; Plca
Alternate Names
protein disulfide-isomerase A3; p58; ER protein 57; ER protein 60; phospholipase C, alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum protein; 58 kDa glucose-regulated protein; glucose regulated protein, 58 kDa; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60
Chromosome
2
Map Location
2 E5|2 60.38 cM
EC Number
5.3.4.1
Proteins
protein disulfide-isomerase A3 precursor | |
---|---|
Refseq ID | NP_031978 |
Protein GI | 112293264 |
UniProt ID | P27773 |
mRNA ID | NM_007952 |
Length | 505 |
RefSeq Status | VALIDATED |
MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL | |
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2429 peptide sequence: MRFSCLALLPGVALLLASARLAAA mat_peptide: 25..505 product: Protein disulfide-isomerase A3 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P27773.2) calculated_mol_wt: 54268 peptide sequence: SDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL |
Gene Information
Entrez Gene ID
Gene Name
protein disulfide isomerase associated 3
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0009986 | IDA:MGI | C | cell surface |
GO:0005783 | IDA:MGI | C | endoplasmic reticulum |
GO:0005788 | TAS:Reactome | C | endoplasmic reticulum lumen |
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0005634 | IEA:Ensembl | C | nucleus |
GO:0044822 | IEA:Ensembl | F | poly(A) RNA binding |
GO:0003756 | IBA:RefGenome | F | protein disulfide isomerase activity |
GO:0045454 | IEA:InterPro | P | cell redox homeostasis |
GO:2001238 | IMP:MGI | P | positive regulation of extrinsic apoptotic signaling pathway |
GO:0006457 | IBA:RefGenome | P | protein folding |
GO:0034976 | IBA:RefGenome | P | response to endoplasmic reticulum stress |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
mmu04612 | Antigen processing and presentation |
mmu04141 | Protein processing in endoplasmic reticulum |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
protein disulfide isomerase associated 3
Protein Entry
PDIA3_MOUSE
UniProt ID
Species
Mouse
Comments
Comment Type | Description |
---|---|
Catalytic Activity | Catalyzes the rearrangement of -S-S- bonds in proteins. |
Caution | Was originally thought to be a phosphatidylinositol 4,5- bisphosphate phosphodiesterase type I (phospholipase C-alpha). {ECO:0000305|PubMed:2033248}. |
Ptm | Phosphorylated. {ECO:0000269|Ref.7}. |
Similarity | Belongs to the protein disulfide isomerase family. {ECO:0000305}. |
Similarity | Contains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000250}. |
Subunit | Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX (By similarity). Interacts with MZB1 in a calcium-dependent manner. Interacts with SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). {ECO:0000250}. |
Tissue Specificity | In caput and cauda epididymal spermatozoa, detected in the acrosome and principal piece (at protein level). {ECO:0000269|PubMed:20400973}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004304 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
112293264 | RefSeq | NP_031978 | 505 | protein disulfide-isomerase A3 precursor |
Identical Sequences to LMP004304 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:112293264 | GenBank | AAH03285.1 | 505 | Protein disulfide isomerase associated 3 [Mus musculus] |
GI:112293264 | GenBank | AAH33439.1 | 505 | Protein disulfide isomerase associated 3 [Mus musculus] |
GI:112293264 | GenBank | AAY16987.1 | 505 | brain glucose regulatory protein [Mus musculus] |
GI:112293264 | GenBank | EDL28055.1 | 505 | protein disulfide isomerase associated 3 [Mus musculus] |
GI:112293264 | SwissProt | P27773.2 | 505 | RecName: Full=Protein disulfide-isomerase A3; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; Flags: Precursor [Mus musculus] |
Related Sequences to LMP004304 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:112293264 | DBBJ | BAC40527.1 | 505 | unnamed protein product [Mus musculus] |
GI:112293264 | DBBJ | BAE39834.1 | 505 | unnamed protein product [Mus musculus] |
GI:112293264 | DBBJ | BAE21849.1 | 495 | unnamed protein product, partial [Mus musculus] |
GI:112293264 | GenBank | AAA39944.1 | 504 | phospholipase C-alpha [Mus musculus] |
GI:112293264 | GenBank | AAH62393.1 | 505 | Protein disulfide isomerase family A, member 3 [Rattus norvegicus] |
GI:112293264 | SwissProt | P11598.2 | 505 | RecName: Full=Protein disulfide-isomerase A3; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; AltName: Full=HIP-70; AltName: Full=Q-2; Flags: Precursor [Rattus norvegicus] |