Gene/Proteome Database (LMPD)

LMPD ID
LMP004304
Gene ID
14827
Species
Mus musculus (Mouse)
Gene Name
protein disulfide isomerase associated 3
Gene Symbol
Pdia3
Synonyms
58kDa; ERp57; ERp60; ERp61; Erp; Grp58; PDI; PDI-Q2; PI-PLC; PLC[a]; Plca
Alternate Names
protein disulfide-isomerase A3; p58; ER protein 57; ER protein 60; phospholipase C, alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum protein; 58 kDa glucose-regulated protein; glucose regulated protein, 58 kDa; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60
Chromosome
2
Map Location
2 E5|2 60.38 cM
EC Number
5.3.4.1

Proteins

protein disulfide-isomerase A3 precursor
Refseq ID NP_031978
Protein GI 112293264
UniProt ID P27773
mRNA ID NM_007952
Length 505
RefSeq Status VALIDATED
MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2429 peptide sequence: MRFSCLALLPGVALLLASARLAAA mat_peptide: 25..505 product: Protein disulfide-isomerase A3 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P27773.2) calculated_mol_wt: 54268 peptide sequence: SDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL

Gene Information

Entrez Gene ID
14827
Gene Name
protein disulfide isomerase associated 3
Gene Symbol
Pdia3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:MGI C cell surface
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005788 TAS:Reactome C endoplasmic reticulum lumen
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0003756 IBA:RefGenome F protein disulfide isomerase activity
GO:0045454 IEA:InterPro P cell redox homeostasis
GO:2001238 IMP:MGI P positive regulation of extrinsic apoptotic signaling pathway
GO:0006457 IBA:RefGenome P protein folding
GO:0034976 IBA:RefGenome P response to endoplasmic reticulum stress

KEGG Pathway Links

KEGG Pathway ID Description
mmu04612 Antigen processing and presentation
mmu04141 Protein processing in endoplasmic reticulum

REACTOME Pathway Links

REACTOME Pathway ID Description
5893913 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
5893930 ER-Phagosome pathway

Domain Information

InterPro Annotations

Accession Description
IPR005788 Disulphide_isomerase
IPR005792 Protein disulphide isomerase
IPR017937 Thioredoxin, conserved site
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin_domain

UniProt Annotations

Entry Information

Gene Name
protein disulfide isomerase associated 3
Protein Entry
PDIA3_MOUSE
UniProt ID
P27773
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Catalyzes the rearrangement of -S-S- bonds in proteins.
Caution Was originally thought to be a phosphatidylinositol 4,5- bisphosphate phosphodiesterase type I (phospholipase C-alpha). {ECO:0000305|PubMed:2033248}.
Ptm Phosphorylated. {ECO:0000269|Ref.7}.
Similarity Belongs to the protein disulfide isomerase family. {ECO:0000305}.
Similarity Contains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular Location Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000250}.
Subunit Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX (By similarity). Interacts with MZB1 in a calcium-dependent manner. Interacts with SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). {ECO:0000250}.
Tissue Specificity In caput and cauda epididymal spermatozoa, detected in the acrosome and principal piece (at protein level). {ECO:0000269|PubMed:20400973}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004304 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
112293264 RefSeq NP_031978 505 protein disulfide-isomerase A3 precursor

Identical Sequences to LMP004304 proteins

Reference Database Accession Length Protein Name
GI:112293264 GenBank AAH03285.1 505 Protein disulfide isomerase associated 3 [Mus musculus]
GI:112293264 GenBank AAH33439.1 505 Protein disulfide isomerase associated 3 [Mus musculus]
GI:112293264 GenBank AAY16987.1 505 brain glucose regulatory protein [Mus musculus]
GI:112293264 GenBank EDL28055.1 505 protein disulfide isomerase associated 3 [Mus musculus]
GI:112293264 SwissProt P27773.2 505 RecName: Full=Protein disulfide-isomerase A3; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; Flags: Precursor [Mus musculus]

Related Sequences to LMP004304 proteins

Reference Database Accession Length Protein Name
GI:112293264 DBBJ BAC40527.1 505 unnamed protein product [Mus musculus]
GI:112293264 DBBJ BAE39834.1 505 unnamed protein product [Mus musculus]
GI:112293264 DBBJ BAE21849.1 495 unnamed protein product, partial [Mus musculus]
GI:112293264 GenBank AAA39944.1 504 phospholipase C-alpha [Mus musculus]
GI:112293264 GenBank AAH62393.1 505 Protein disulfide isomerase family A, member 3 [Rattus norvegicus]
GI:112293264 SwissProt P11598.2 505 RecName: Full=Protein disulfide-isomerase A3; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; AltName: Full=HIP-70; AltName: Full=Q-2; Flags: Precursor [Rattus norvegicus]