Gene/Proteome Database (LMPD)

LMPD ID
LMP004325
Gene ID
123096
Species
Homo sapiens (Human)
Gene Name
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Gene Symbol
SLC25A29
Synonyms
C14orf69; CACL; ORNT3
Alternate Names
mitochondrial basic amino acids transporter; solute carrier family 25, member 29; mitochondrial ornithine transporter 3; carnitine-acylcarnitine translocase like; carnitine/acylcarnitine translocase-like; mitochondrial carnitine/acylcarnitine carrier protein CACL
Chromosome
14
Map Location
14q32.2
Summary
This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Orthologs
View orthologs and multiple alignments for SLC25A29

Proteins

mitochondrial basic amino acids transporter isoform 1
Refseq ID NP_001034444
Protein GI 86198310
UniProt ID Q8N8R3
mRNA ID NM_001039355
Length 303
RefSeq Status REVIEWED
MALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEEAGPEGEAVPAAPAGPALAQPSSL
mitochondrial basic amino acids transporter isoform 2
Refseq ID NP_689546
Protein GI 22748727
UniProt ID Q8N8R3
mRNA ID NM_152333
Length 237
RefSeq Status REVIEWED
MGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEEAGPEGEAVPAAPAGPALAQPSSL
mitochondrial basic amino acids transporter isoform 2
Refseq ID NP_001278743
Protein GI 625180323
UniProt ID Q8N8R3
mRNA ID NM_001291814
Length 237
RefSeq Status REVIEWED
Protein sequence is identical to GI:22748727 (mRNA isoform)
mitochondrial basic amino acids transporter isoform 2
Refseq ID NP_001278742
Protein GI 625180321
UniProt ID Q8N8R3
mRNA ID NM_001291813
Length 237
RefSeq Status REVIEWED
Protein sequence is identical to GI:22748727 (mRNA isoform)

Gene Information

Entrez Gene ID
123096
Gene Name
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Gene Symbol
SLC25A29
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0015227 IEA:Ensembl F acyl carnitine transmembrane transporter activity

Domain Information

InterPro Annotations

Accession Description
IPR023395 Mitochondrial carrier domain
IPR002067 Mitochondrial carrier protein
IPR018108 Mitochondrial substrate/solute carrier

UniProt Annotations

Entry Information

Gene Name
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Protein Entry
MCATL_HUMAN
UniProt ID
Q8N8R3
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N8R3-1; Sequence=Displayed; Name=2; IsoId=Q8N8R3-2; Sequence=VSP_046286, VSP_046287; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q8N8R3-3; Sequence=VSP_055335; Note=No experimental confirmation available.;
Function Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms.
Sequence Caution Sequence=CAD62317.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity Contains 3 Solcar repeats. {ECO
Subcellular Location Mitochondrion inner membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP004325 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
86198310 RefSeq NP_001034444 303 mitochondrial basic amino acids transporter isoform 1
22748727 RefSeq NP_689546 237 mitochondrial basic amino acids transporter isoform 2

Identical Sequences to LMP004325 proteins

Reference Database Accession Length Protein Name
GI:86198310 DBBJ BAD18767.1 303 unnamed protein product [Homo sapiens]
GI:86198310 DBBJ BAG53964.1 303 unnamed protein product [Homo sapiens]
GI:86198310 GenBank EAW81695.1 303 solute carrier family 25, member 29, isoform CRA_d [Homo sapiens]
GI:22748727 GenBank AIC61221.1 237 SLC25A29, partial [synthetic construct]
GI:22748727 RefSeq XP_009247758.1 237 PREDICTED: mitochondrial basic amino acids transporter isoform X2 [Pongo abelii]
GI:22748727 RefSeq XP_009247759.1 237 PREDICTED: mitochondrial basic amino acids transporter isoform X2 [Pongo abelii]
GI:22748727 RefSeq XP_009247760.1 237 PREDICTED: mitochondrial basic amino acids transporter isoform X2 [Pongo abelii]
GI:22748727 RefSeq XP_009247761.1 237 PREDICTED: mitochondrial basic amino acids transporter isoform X2 [Pongo abelii]
GI:22748727 RefSeq XP_009247762.1 237 PREDICTED: mitochondrial basic amino acids transporter isoform X2 [Pongo abelii]
GI:86198310 SwissProt Q8N8R3.2 303 RecName: Full=Mitochondrial basic amino acids transporter; AltName: Full=Carnitine/acylcarnitine translocase-like; Short=CACT-like; AltName: Full=Mitochondrial carnitine/acylcarnitine carrier protein CACL; AltName: Full=Mitochondrial ornithine transporter 3; AltName: Full=Solute carrier family 25 member 29 [Homo sapiens]

Related Sequences to LMP004325 proteins

Reference Database Accession Length Protein Name
GI:22748727 DBBJ BAD18767.1 303 unnamed protein product [Homo sapiens]
GI:22748727 DBBJ BAG53964.1 303 unnamed protein product [Homo sapiens]
GI:22748727 EMBL CAD62317.1 400 unnamed protein product, partial [Homo sapiens]
GI:86198310 EMBL CAD62317.1 400 unnamed protein product, partial [Homo sapiens]
GI:22748727 GenBank EAW81695.1 303 solute carrier family 25, member 29, isoform CRA_d [Homo sapiens]
GI:86198310 GenBank JAA16789.1 303 solute carrier family 25, member 29 [Pan troglodytes]
GI:86198310 GenBank JAA25482.1 303 solute carrier family 25, member 29 [Pan troglodytes]
GI:86198310 GenBank JAA33953.1 303 solute carrier family 25, member 29 [Pan troglodytes]
GI:22748727 RefSeq NP_001034444.1 303 mitochondrial basic amino acids transporter isoform 1 [Homo sapiens]
GI:86198310 RefSeq XP_002825151.2 303 PREDICTED: mitochondrial basic amino acids transporter isoform X1 [Pongo abelii]
GI:86198310 RefSeq XP_004055738.1 303 PREDICTED: mitochondrial carnitine/acylcarnitine carrier protein CACL [Gorilla gorilla gorilla]
GI:22748727 SwissProt Q8N8R3.2 303 RecName: Full=Mitochondrial basic amino acids transporter; AltName: Full=Carnitine/acylcarnitine translocase-like; Short=CACT-like; AltName: Full=Mitochondrial carnitine/acylcarnitine carrier protein CACL; AltName: Full=Mitochondrial ornithine transporter 3; AltName: Full=Solute carrier family 25 member 29 [Homo sapiens]