Gene/Proteome Database (LMPD)

LMPD ID
LMP004404
Gene ID
19661
Species
Mus musculus (Mouse)
Gene Name
retinol binding protein 3, interstitial
Gene Symbol
Rbp3
Synonyms
Irbp; Rbp-3
Alternate Names
retinol-binding protein 3; interstitial retinol-binding protein; interphotoreceptor retinoid-binding protein
Chromosome
14
Map Location
14 B|14 20.8 cM

Proteins

retinol-binding protein 3 precursor
Refseq ID NP_056560
Protein GI 21729751
UniProt ID P49194
mRNA ID NM_015745
Length 1234
RefSeq Status PROVISIONAL
MMREWVLVLSTLLWVPAGPTHLFQPSLVLDMAKILLDNYCFPENLMGMQAAIEQAMKSHEILGISDPQTLAQVLTAGVQSSLSDPRLFISYEPSTLEAPQQAPVLTNLTREELLAQIQRNIRHEVLEGNVGYLRVDDLPGQEVLSELGEFLVSHVWRQLMSTSSLVLDLRHCSGGHFSGIPYVISYLHPGNTVMHVDTVYDRPSNTTTEIWTLPEVLGERYSADKDVVVLTSGHTGGVAEDIAYILKQMRRAIVVGERTEGGALDLQKLRIGQSNFFLTVPVSRSLGPLGGGGQTWEGSGVLPCVGTPAEQALEKALAILTLRRALPGVVLRLQEALQDYYTLVDRVPGLLHHLASMDYSAVVSEEDLVTKLNAGLQAVSEDPRLLVRATGPRDSSSRPETGPNESPAATPEVPTEEDARRALVDSVFQVSVLPGNVGYLRFDRFADAAVLETLGPYVLKQVWEPLQDTEHLIMDLRHNPGGPSSAMPLVLSYFQGPEAGPVRLFTTYDRRTNITQEHFSHRELLGQRYGNQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGSLLHTCTVPLLDSPQGGLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALERAQEVLDFHRSLGALVEGTGRLLEAHYARPEIAQRARALLQSKLAQGAYRTAVDLESLASQLTADLQEVSEDHRLLVFHSPGELVAEEVPLPPPAVPSPEELSYLIEALFKTDVLPGQLGYLRFDAMAELETVKAIGPQLVQLVWQRLVDTAALIVDLRYNPGSYSSAVPLLCSYFFEAEPRQHLYSVFDRATSRVTEIWTLPLVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGNSPLYASMPTQMALSASTGEAWDLAGVEPDITVPMSEALSTAQDIVVLRAKVPTVLQTAGKLVADNYASPELGAKMAAKLSGLQSRYARVTSEGALAEMLGADLQILSGDPHLKTAHIPEDAKDRIPGIVPMQIPSPEVFEDLIKFSFHTNVLEDNIGYLRFDMFGDCELLTQVSELLVEHIWKKIVHTDALIIDMRFNLGGPTSSISALCSYFFDEAPPILLDKIYNRPNDSVSELWTHTQLTGERYGSKKSVAILTSGVTAGAAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTHLYITIPTARSVGAEDGSSWEGVGVTPNVVVSSELALTRAKEILQQALRG
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2045 peptide sequence: MMREWVLVLSTLLWVPA mat_peptide: 18..1234 product: Retinol-binding protein 3 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P49194.3) calculated_mol_wt: 132455 peptide sequence: GPTHLFQPSLVLDMAKILLDNYCFPENLMGMQAAIEQAMKSHEILGISDPQTLAQVLTAGVQSSLSDPRLFISYEPSTLEAPQQAPVLTNLTREELLAQIQRNIRHEVLEGNVGYLRVDDLPGQEVLSELGEFLVSHVWRQLMSTSSLVLDLRHCSGGHFSGIPYVISYLHPGNTVMHVDTVYDRPSNTTTEIWTLPEVLGERYSADKDVVVLTSGHTGGVAEDIAYILKQMRRAIVVGERTEGGALDLQKLRIGQSNFFLTVPVSRSLGPLGGGGQTWEGSGVLPCVGTPAEQALEKALAILTLRRALPGVVLRLQEALQDYYTLVDRVPGLLHHLASMDYSAVVSEEDLVTKLNAGLQAVSEDPRLLVRATGPRDSSSRPETGPNESPAATPEVPTEEDARRALVDSVFQVSVLPGNVGYLRFDRFADAAVLETLGPYVLKQVWEPLQDTEHLIMDLRHNPGGPSSAMPLVLSYFQGPEAGPVRLFTTYDRRTNITQEHFSHRELLGQRYGNQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGSLLHTCTVPLLDSPQGGLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALERAQEVLDFHRSLGALVEGTGRLLEAHYARPEIAQRARALLQSKLAQGAYRTAVDLESLASQLTADLQEVSEDHRLLVFHSPGELVAEEVPLPPPAVPSPEELSYLIEALFKTDVLPGQLGYLRFDAMAELETVKAIGPQLVQLVWQRLVDTAALIVDLRYNPGSYSSAVPLLCSYFFEAEPRQHLYSVFDRATSRVTEIWTLPLVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGNSPLYASMPTQMALSASTGEAWDLAGVEPDITVPMSEALSTAQDIVVLRAKVPTVLQTAGKLVADNYASPELGAKMAAKLSGLQSRYARVTSEGALAEMLGADLQILSGDPHLKTAHIPEDAKDRIPGIVPMQIPSPEVFEDLIKFSFHTNVLEDNIGYLRFDMFGDCELLTQVSELLVEHIWKKIVHTDALIIDMRFNLGGPTSSISALCSYFFDEAPPILLDKIYNRPNDSVSELWTHTQLTGERYGSKKSVAILTSGVTAGAAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTHLYITIPTARSVGAEDGSSWEGVGVTPNVVVSSELALTRAKEILQQALRG

Gene Information

Entrez Gene ID
19661
Gene Name
retinol binding protein 3, interstitial
Gene Symbol
Rbp3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:Ensembl C extracellular space
GO:0033165 IEA:Ensembl C interphotoreceptor matrix
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0019841 IEA:Ensembl F retinol binding
GO:0008236 IEA:InterPro F serine-type peptidase activity
GO:0006810 IEA:UniProtKB-KW P transport

REACTOME Pathway Links

REACTOME Pathway ID Description
5892892 Diseases associated with visual transduction
5892894 The canonical retinoid cycle in rods (twilight vision)
5894091 The retinoid cycle in cones (daylight vision)
5892890 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR005151 Tail specific protease

UniProt Annotations

Entry Information

Gene Name
retinol binding protein 3, interstitial
Protein Entry
RET3_MOUSE
UniProt ID
P49194
Species
Mouse

Comments

Comment Type Description
Function IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
Similarity Belongs to the peptidase S41A family. {ECO:0000305}.
Subcellular Location Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Tissue Specificity Expressed in the photosensitive tissues; retina and pineal gland. {ECO:0000269|PubMed:1342928}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004404 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21729751 RefSeq NP_056560 1234 retinol-binding protein 3 precursor

Identical Sequences to LMP004404 proteins

Reference Database Accession Length Protein Name
GI:21729751 GenBank AAH17610.1 1234 Retinol binding protein 3, interstitial [Mus musculus]
GI:21729751 GenBank AAH42480.1 1234 Retinol binding protein 3, interstitial [Mus musculus]
GI:21729751 GenBank AAH83133.1 1234 Retinol binding protein 3, interstitial [Mus musculus]

Related Sequences to LMP004404 proteins

Reference Database Accession Length Protein Name
GI:21729751 GenBank AAT81142.1 1234 interphotoreceptor retinoid-binding protein precursor [Mus musculus]
GI:21729751 GenBank EDL24863.1 1232 retinol binding protein 3, interstitial [Mus musculus]
GI:21729751 GenBank EDL88892.1 1234 retinol binding protein 3, interstitial [Rattus norvegicus]
GI:21729751 RefSeq NP_001178761.1 1234 retinol-binding protein 3 precursor [Rattus norvegicus]
GI:21729751 RefSeq XP_006976770.1 1236 PREDICTED: retinol-binding protein 3 [Peromyscus maniculatus bairdii]
GI:21729751 SwissProt P49194.3 1234 RecName: Full=Retinol-binding protein 3; AltName: Full=Interphotoreceptor retinoid-binding protein; Short=IRBP; AltName: Full=Interstitial retinol-binding protein; Flags: Precursor [Mus musculus]