Gene/Proteome Database (LMPD)

LMPD ID
LMP004429
Gene ID
98711
Species
Mus musculus (Mouse)
Gene Name
retinol dehydrogenase 10 (all-trans)
Gene Symbol
Rdh10
Synonyms
3110069K09Rik; 4921506A21Rik; AI875664; AW549993; D1Ertd762e; m366Asp
Alternate Names
retinol dehydrogenase 10
Chromosome
1
Map Location
1 A3|1 4.94 cM
EC Number
1.1.1.300

Proteins

retinol dehydrogenase 10
Refseq ID NP_598593
Protein GI 25141231
UniProt ID Q8VCH7
mRNA ID NM_133832
Length 341
RefSeq Status PROVISIONAL
MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGKGEEEILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMRAILTDQPMVCTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI

Gene Information

Entrez Gene ID
98711
Gene Name
retinol dehydrogenase 10 (all-trans)
Gene Symbol
Rdh10
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044297 IEA:Ensembl C cell body
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:MGI C membrane
GO:0052650 IEA:UniProtKB-EC F NADP-retinol dehydrogenase activity
GO:0004745 IMP:MGI F retinol dehydrogenase activity
GO:0060449 IMP:MGI P bud elongation involved in lung branching
GO:0043583 IMP:MGI P ear development
GO:0031076 IMP:MGI P embryonic camera-type eye development
GO:0035115 IMP:MGI P embryonic forelimb morphogenesis
GO:0048568 IMP:MGI P embryonic organ development
GO:0048703 IMP:MGI P embryonic viscerocranium morphogenesis
GO:0008406 IMP:MGI P gonad development
GO:0001701 IMP:MGI P in utero embryonic development
GO:0001656 IMP:MGI P metanephros development
GO:0014032 IMP:MGI P neural crest cell development
GO:0043584 IMP:MGI P nose development
GO:0009887 IMP:MGI P organ morphogenesis
GO:0060431 IMP:MGI P primary lung bud formation
GO:0042574 IEA:Ensembl P retinal metabolic process
GO:0002138 IMP:MGI P retinoic acid biosynthetic process
GO:0007601 ISA:MGI P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5892894 The canonical retinoid cycle in rods (twilight vision)

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 10 (all-trans)
Protein Entry
RDH10_MOUSE
UniProt ID
Q8VCH7
Species
Mouse

Comments

Comment Type Description
Catalytic Activity All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
Developmental Stage First detected in the neural groove at E8.0. At E8.5, detected in lateral plate mesoderm, the dorsal region of the somites, the floor plate of the neural tube and in head mesenchyme. At E9.5, detected in dorsal paraxial mesoderm, lateral plate mesoderm and in nephrogenic cord tissues. At E10.5, detected in lung buds, developing mesonephros, mesodermal tissue surrounding dorsal root ganglia and adjacent to the forlimb buds. {ECO:0000269|PubMed:17473173}.
Function Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development. {ECO:0000250, ECO:0000269|PubMed:17473173}.
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Detected in retinal pigment epithelium (at protein level). {ECO:0000269|PubMed:12407145, ECO:0000269|PubMed:15505029}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004429 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25141231 RefSeq NP_598593 341 retinol dehydrogenase 10

Identical Sequences to LMP004429 proteins

Reference Database Accession Length Protein Name
GI:25141231 GenBank AAN64749.1 341 retinol dehydrogenase 10 [Mus musculus]
GI:25141231 GenBank AAH19796.2 341 Retinol dehydrogenase 10 (all-trans) [Mus musculus]
GI:25141231 GenBank EDL14341.1 341 retinol dehydrogenase 10 (all-trans), isoform CRA_a [Mus musculus]
GI:25141231 SwissProt Q8VCH7.2 341 RecName: Full=Retinol dehydrogenase 10 [Mus musculus]

Related Sequences to LMP004429 proteins

Reference Database Accession Length Protein Name
GI:25141231 GenBank AAO31688.1 341 retinol dehydrogenase 10 [Rattus norvegicus]
GI:25141231 GenBank EDM11512.1 341 retinol dehydrogenase 10 (all-trans), isoform CRA_b [Rattus norvegicus]
GI:25141231 RefSeq NP_852143.1 341 retinol dehydrogenase 10 [Rattus norvegicus]
GI:25141231 RefSeq XP_004602445.1 341 PREDICTED: retinol dehydrogenase 10 [Sorex araneus]
GI:25141231 RefSeq XP_006974775.1 341 PREDICTED: retinol dehydrogenase 10 [Peromyscus maniculatus bairdii]
GI:25141231 SwissProt Q80ZF7.1 341 RecName: Full=Retinol dehydrogenase 10 [Rattus norvegicus]