Gene/Proteome Database (LMPD)
Proteins
| nuclear receptor-interacting protein 1 | |
|---|---|
| Refseq ID | NP_775616 |
| Protein GI | 27734110 |
| UniProt ID | Q8CBD1 |
| mRNA ID | NM_173440 |
| Length | 1161 |
| RefSeq Status | PROVISIONAL |
| MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAINKKSAGHKEEDQNFNLSGSAFPSCQSNGPTVSTQTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIVNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHESLKVEKDLRCYGVASSHLKTLLKKSKTKDQKSGPTLPDVTPNLIRDSFVESSHPAVGQSGTKVMSEPLSCAARLQAVASMVEKRASPAASPKPSVACSQLALLLSSEAHLQQYSREHALKTQNAHQVASERLAAMARLQENGQKDVGSSQLSKGVSGHLNGQARALPASKLVANKNNAATFQSPMGVVPSSPKNTSYKNSLERNNLKQAANNSLLLHLLKSQTIPTPMNGHSQNERASSFESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRIEKPEAERPVSLENLTQSLLNTWDPKIPGVDIKEDQDTSTNSKLNSHQKVTLLQLLLGHKSEETVERNASPQDIHSDGTKFSPQNYTRTSVIESPSTNRTTPVSTPPLYTASQAESPINLSQHSLVIKWNSPPYACSTPASKLTNTAPSHLMDLTKGKESQAEKPAPSEGAQNSATFSASKLLQNLAQCGLQSSGPGEEQRPCKQLLSGNPDKPLGLIDRLNSPLLSNKTNAAEESKAFSSQPAGPEPGLPGCEIENLLERRTVLQLLLGNSSKGKNEKKEKTPARDEAPQEHSERAANEQILMVKIKSEPCDDFQTHNTNLPLNHDAKSAPFLGVTPAIHRSTAALPVSEDFKSEPASPQDFSFSKNGLLSRLLRQNQESYPADEQDKSHRNSELPTLESKNICMVPKKRKLYTEPLENPFKKMKNTAVDTANHHSGPEVLYGSLLHQEELKFSRNELDYKYPAGHSSASDGDHRSWARESKSFNVLKQLLLSENCVRDLSPHRSDSVPDTKKKGHKNNAPGSKPEFGISSLNGLMYSSPQPGSCVTDHRTFSYPGMVKTPLSPPFPEHLGCVGSRPEPGLLNGCSVPGEKGPIKWVIADMDKNEYEKDSPRLTKTNPILYYMLQKGGGNSVTTQETQDKDIWREPASAESLSQVTVKEELLPAAETKASFFNLRSPYNSHMGNNASRPHSTNGEVYGLLGNALTIKKESE | |
Gene Information
Entrez Gene ID
Gene Name
nuclear receptor interacting protein 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030054 | IEA:Ensembl | C | cell junction |
| GO:0000118 | IPI:UniProtKB | C | histone deacetylase complex |
| GO:0016607 | IDA:MGI | C | nuclear speck |
| GO:0005634 | IDA:UniProtKB | C | nucleus |
| GO:0042826 | IPI:UniProtKB | F | histone deacetylase binding |
| GO:0005102 | IPI:UniProtKB | F | receptor binding |
| GO:0042974 | IPI:UniProtKB | F | retinoic acid receptor binding |
| GO:0046965 | IPI:UniProtKB | F | retinoid X receptor binding |
| GO:0003713 | IEA:Ensembl | F | transcription coactivator activity |
| GO:0003714 | IDA:MGI | F | transcription corepressor activity |
| GO:0019915 | IMP:UniProtKB | P | lipid storage |
| GO:0000122 | IDA:MGI | P | negative regulation of transcription from RNA polymerase II promoter |
| GO:0001543 | IMP:UniProtKB | P | ovarian follicle rupture |
| GO:0030728 | IMP:UniProtKB | P | ovulation |
| GO:0045944 | IEA:Ensembl | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0006357 | IDA:MGI | P | regulation of transcription from RNA polymerase II promoter |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026649 | Nuclear receptor-interacting protein 1 |
UniProt Annotations
Entry Information
Gene Name
nuclear receptor interacting protein 1
Protein Entry
Q8CBD1_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Domain | Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. |
| Domain | Contains at least 4 autonomous repression domains (RD1-4). |
| Domain | The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB. |
| Function | Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. {ECO:0000269|PubMed:10531331, ECO:0000269|PubMed:11100122, ECO:0000269|PubMed:15130509, ECO:0000269|PubMed:15155905, ECO:0000269|PubMed:15919748, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:9774688}. |
| Interaction | O15379:HDAC3 (xeno); NbExp=2; IntAct=EBI-1771626, EBI-607682; |
| Ptm | Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH (By similarity). Acetylation regulates its nuclear translocation and corepressive activity. {ECO:0000250|UniProtKB:P48552, ECO:0000269|PubMed:15846843, ECO:0000269|PubMed:15879431}. |
| Subcellular Location | Nucleus . |
| Subunit | Interacts with CTBP1, CTBP2, ERS1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH (By similarity). Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with ZNF366 (By similarity). Interacts with RORA. {ECO:0000250|UniProtKB:P48552, ECO:0000269|PubMed:21628546}. |
| Tissue Specificity | Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. {ECO:0000269|PubMed:11100122, ECO:0000269|PubMed:15155905, ECO:0000269|PubMed:9774688}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004430 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 27734110 | RefSeq | NP_775616 | 1161 | nuclear receptor-interacting protein 1 |
Identical Sequences to LMP004430 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:27734110 | GenBank | AGU20522.1 | 1161 | Sequence 8 from patent US 8519118 |
| GI:27734110 | RefSeq | XP_006523113.1 | 1161 | PREDICTED: nuclear receptor-interacting protein 1 isoform X1 [Mus musculus] |
| GI:27734110 | RefSeq | XP_006523114.1 | 1161 | PREDICTED: nuclear receptor-interacting protein 1 isoform X2 [Mus musculus] |
| GI:27734110 | RefSeq | XP_006523115.1 | 1161 | PREDICTED: nuclear receptor-interacting protein 1 isoform X3 [Mus musculus] |
| GI:27734110 | RefSeq | XP_006523116.1 | 1161 | PREDICTED: nuclear receptor-interacting protein 1 isoform X4 [Mus musculus] |
| GI:27734110 | RefSeq | XP_006523117.1 | 1161 | PREDICTED: nuclear receptor-interacting protein 1 isoform X5 [Mus musculus] |
Related Sequences to LMP004430 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:27734110 | DBBJ | BAE33634.1 | 1068 | unnamed protein product, partial [Mus musculus] |
| GI:27734110 | GenBank | AAC69611.1 | 1161 | receptor interacting protein 140 [Mus musculus] |
| GI:27734110 | GenBank | EDM10585.1 | 1162 | RGD1563102 (predicted) [Rattus norvegicus] |
| GI:27734110 | RefSeq | NP_001094030.1 | 1162 | nuclear receptor-interacting protein 1 [Rattus norvegicus] |
| GI:27734110 | RefSeq | XP_006983657.1 | 1163 | PREDICTED: nuclear receptor-interacting protein 1 [Peromyscus maniculatus bairdii] |
| GI:27734110 | RefSeq | XP_007638232.1 | 1172 | PREDICTED: nuclear receptor-interacting protein 1 [Cricetulus griseus] |