Gene/Proteome Database (LMPD)

LMPD ID
LMP004460
Gene ID
71795
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol transfer protein, cytoplasmic 1
Gene Symbol
Pitpnc1
Synonyms
1110020B03Rik; 5830436L09Rik; AI662802; AI851387; C330017I21Rik; Dnr411; RDGBB; RDGBB1; rdgB-beta
Alternate Names
cytoplasmic phosphatidylinositol transfer protein 1; rdgBbeta; mrdgBbeta; M-rdgB beta; mM-rdgBbeta; mammalian rdgB homolog beta; retinal degeneration B beta; retinal degeneration B homolog beta; diabetic nephropathy-related protein
Chromosome
11
Map Location
11 E1|11

Proteins

cytoplasmic phosphatidylinositol transfer protein 1
Refseq ID NP_665822
Protein GI 22003862
UniProt ID Q8K4R4
mRNA ID NM_145823
Length 268
RefSeq Status PROVISIONAL
MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDSIFDSEAKDLEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDNHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDDVREYEKNMHEQTNIKVCNQHSSTVDDIESHAQTST

Gene Information

Entrez Gene ID
71795
Gene Name
phosphatidylinositol transfer protein, cytoplasmic 1
Gene Symbol
Pitpnc1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0008526 ISS:UniProtKB F phosphatidylinositol transporter activity
GO:0007165 ISS:UniProtKB P signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR001666 Phosphatidylinositol transfer protein
IPR023393 START-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol transfer protein, cytoplasmic 1
Protein Entry
PITC1_MOUSE
UniProt ID
Q8K4R4
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=mM-rdgBbeta; IsoId=Q8K4R4-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; Synonyms=mM-rdgBbeta1; IsoId=Q8K4R4-2; Sequence=VSP_025549, VSP_025551; Name=3; IsoId=Q8K4R4-3; Sequence=VSP_025548, VSP_025550; Note=No experimental confirmation available.; Name=4; IsoId=Q8K4R4-4; Sequence=VSP_025546, VSP_025547; Note=No experimental confirmation available.;
Function Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Isoform 2 specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development. {ECO:0000269|PubMed:12562526}.
Sequence Caution Sequence=CAM17314.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM17315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM20627.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM25441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM25442.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily. {ECO:0000305}.
Subcellular Location Isoform 1: Cytoplasm.
Subcellular Location Isoform 2: Cytoplasm. Nucleus.
Tissue Specificity Isoform 1 is widely expressed. Isoform 2 is weakly expressed. In brain, isoform 2 is weakly expressed and is rather confined to the embryonic stage. In contrast, isoform 1 is widely expressed in brain, with expression in the gray matters of pre- and postnatal brains. {ECO:0000269|PubMed:12562526}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004460 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22003862 RefSeq NP_665822 268 cytoplasmic phosphatidylinositol transfer protein 1

Identical Sequences to LMP004460 proteins

Reference Database Accession Length Protein Name
GI:22003862 DBBJ BAC02913.1 268 splicing variant of retinal degeneration B beta [Mus musculus]
GI:22003862 GenBank AAI08352.1 268 Phosphatidylinositol transfer protein, cytoplasmic 1 [Mus musculus]

Related Sequences to LMP004460 proteins

Reference Database Accession Length Protein Name
GI:22003862 RefSeq XP_003913377.1 268 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X5 [Papio anubis]
GI:22003862 RefSeq XP_005350489.1 268 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X2 [Microtus ochrogaster]
GI:22003862 RefSeq XP_005328283.1 268 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X2 [Ictidomys tridecemlineatus]
GI:22003862 RefSeq XP_006220943.1 268 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X3 [Rattus norvegicus]
GI:22003862 RefSeq XP_008010213.1 268 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X9 [Chlorocebus sabaeus]
GI:22003862 RefSeq XP_008773641.1 366 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X1 [Rattus norvegicus]