Gene/Proteome Database (LMPD)
LMPD ID
LMP004490
Gene ID
Species
Mus musculus (Mouse)
Gene Name
free fatty acid receptor 2
Gene Symbol
Synonyms
GPCR43; Gpr43
Alternate Names
free fatty acid receptor 2; G protein-coupled receptor 43; G-protein coupled receptor 43; leukocyte-specific STAT-induced GPCR
Chromosome
7
Map Location
7 B1|7
Proteins
| free fatty acid receptor 2 | |
|---|---|
| Refseq ID | NP_666299 |
| Protein GI | 22122727 |
| UniProt ID | Q8VCK6 |
| mRNA ID | NM_146187 |
| Length | 330 |
| RefSeq Status | VALIDATED |
| MTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE | |
| free fatty acid receptor 2 | |
|---|---|
| Refseq ID | NP_001161983 |
| Protein GI | 270341377 |
| UniProt ID | Q8VCK6 |
| mRNA ID | NM_001168511 |
| Length | 330 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:22122727 (mRNA isoform) | |
| free fatty acid receptor 2 | |
|---|---|
| Refseq ID | NP_001161984 |
| Protein GI | 270341379 |
| UniProt ID | Q8VCK6 |
| mRNA ID | NM_001168512 |
| Length | 330 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:22122727 (mRNA isoform) | |
| free fatty acid receptor 2 | |
|---|---|
| Refseq ID | NP_001161981 |
| Protein GI | 270341373 |
| UniProt ID | Q8VCK6 |
| mRNA ID | NM_001168509 |
| Length | 330 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:22122727 (mRNA isoform) | |
| free fatty acid receptor 2 | |
|---|---|
| Refseq ID | NP_001161982 |
| Protein GI | 270341375 |
| UniProt ID | Q8VCK6 |
| mRNA ID | NM_001168510 |
| Length | 330 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:22122727 (mRNA isoform) | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042995 | IEA:Ensembl | C | cell projection |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | ISS:UniProtKB | C | plasma membrane |
| GO:0004930 | IDA:UniProtKB | F | G-protein coupled receptor activity |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0007186 | IDA:UniProtKB | P | G-protein coupled receptor signaling pathway |
| GO:0002752 | ISS:UniProtKB | P | cell surface pattern recognition receptor signaling pathway |
| GO:0071398 | IDA:UniProtKB | P | cellular response to fatty acid |
| GO:0045444 | IMP:UniProtKB | P | fat cell differentiation |
| GO:0042593 | IDA:UniProtKB | P | glucose homeostasis |
| GO:0002232 | IMP:UniProtKB | P | leukocyte chemotaxis involved in inflammatory response |
| GO:0019915 | IDA:UniProtKB | P | lipid storage |
| GO:0002385 | IMP:UniProtKB | P | mucosal immune response |
| GO:0002879 | IMP:UniProtKB | P | positive regulation of acute inflammatory response to non-antigenic stimulus |
| GO:0032722 | IMP:UniProtKB | P | positive regulation of chemokine production |
| GO:0002720 | IMP:UniProtKB | P | positive regulation of cytokine production involved in immune response |
| GO:2000484 | ISS:UniProtKB | P | positive regulation of interleukin-8 secretion |
| GO:0002673 | IMP:UniProtKB | P | regulation of acute inflammatory response |
| GO:0090276 | IDA:UniProtKB | P | regulation of peptide hormone secretion |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5893811 | Free fatty acid receptors |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disruption Phenotype | Knockout mice display altered protective intestinal inflammatory and immune responses but no gross developmental defects. {ECO:0000269|PubMed:18499755, ECO:0000269|PubMed:19865172, ECO:0000269|PubMed:23665276}. |
| Function | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5- trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine (PubMed:22190648, PubMed:23589301). May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake (PubMed:20399779). Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes (PubMed:16123168, PubMed:23589301). In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines (PubMed:23665276). May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils (PubMed:19917676, PubMed:19865172). In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. {ECO:0000269|PubMed:12684041, ECO:0000269|PubMed:16123168, ECO:0000269|PubMed:18499755, ECO:0000269|PubMed:19865172, ECO:0000269|PubMed:19917676, ECO:0000269|PubMed:20399779, ECO:0000269|PubMed:22190648, ECO:0000269|PubMed:23589301, ECO:0000269|PubMed:23665276}. |
| Induction | During differentiation of leukocytes. This induction is STAT3-dependent. Up-regulated in adipose tissues by high-fat diet. {ECO:0000269|PubMed:12393494, ECO:0000269|PubMed:16123168}. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Subunit | Interacts with FCN1 (via Fibrinogen C-terminal domain). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in hematopoietic tissues, such as spleen and bone marrow, with highest levels in a subset of immune cells, including monocytes or neutrophils. Expressed in adipose tissues with high expression in differentiating adipocytes. Expressed by intestinal endocrine cells. {ECO:0000269|PubMed:12393494, ECO:0000269|PubMed:16123168, ECO:0000269|PubMed:22190648}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004490 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22122727 | RefSeq | NP_666299 | 330 | free fatty acid receptor 2 |
Identical Sequences to LMP004490 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22122727 | GenBank | EDL23983.1 | 330 | free fatty acid receptor 2, isoform CRA_a [Mus musculus] |
| GI:22122727 | GenBank | EDL23984.1 | 330 | free fatty acid receptor 2, isoform CRA_a [Mus musculus] |
| GI:22122727 | RefSeq | NP_001161981.1 | 330 | free fatty acid receptor 2 [Mus musculus] |
| GI:22122727 | RefSeq | NP_001161982.1 | 330 | free fatty acid receptor 2 [Mus musculus] |
| GI:22122727 | RefSeq | NP_001161983.1 | 330 | free fatty acid receptor 2 [Mus musculus] |
| GI:22122727 | RefSeq | NP_001161984.1 | 330 | free fatty acid receptor 2 [Mus musculus] |
Related Sequences to LMP004490 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22122727 | DBBJ | BAC34306.1 | 330 | unnamed protein product [Mus musculus] |
| GI:22122727 | DBBJ | BAD02826.1 | 330 | GPR43 [Rattus norvegicus] |
| GI:22122727 | GenBank | AAE58587.1 | 330 | Sequence 2 from patent US 6180365 |
| GI:22122727 | RefSeq | XP_008757355.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
| GI:22122727 | RefSeq | XP_008757356.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
| GI:22122727 | SwissProt | Q76EI6.1 | 330 | RecName: Full=Free fatty acid receptor 2; AltName: Full=G-protein coupled receptor 43 [Rattus norvegicus] |