Gene/Proteome Database (LMPD)

LMPD ID
LMP004523
Gene ID
94242
Species
Mus musculus (Mouse)
Gene Name
tubulointerstitial nephritis antigen-like 1
Gene Symbol
Tinagl1
Synonyms
1110021J17Rik; AZ-1; AZ1; Arg1; Lcn7; TARP; Tinagl
Alternate Names
tubulointerstitial nephritis antigen-like; adrenocortical zonation factor 1; androgen-regulated gene 1 protein; tubulointerstitial nephritis antigen-related protein
Chromosome
4
Map Location
4|4 D3

Proteins

tubulointerstitial nephritis antigen-like precursor
Refseq ID NP_075965
Protein GI 270132817
UniProt ID Q99JR5
mRNA ID NM_023476
Length 466
RefSeq Status VALIDATED
MWGCWLGLLLLLLAGQAALEARRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATCYCDLFCNRTVSDCCPDFWDFCLGIPPPFPPVQGCMHGGRIYPVFGTYWDNCNRCTCHEGGHWECDQEPCLVDPDMIKAINRGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDTHHQQGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPNGQVDSNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPEQYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETFVLGVWGRVGMEDMGHH
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2243 peptide sequence: MWGCWLGLLLLLLAGQAALEA mat_peptide: 22..466 product: Tubulointerstitial nephritis antigen-like experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99JR5.1) calculated_mol_wt: 50440 peptide sequence: RRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATCYCDLFCNRTVSDCCPDFWDFCLGIPPPFPPVQGCMHGGRIYPVFGTYWDNCNRCTCHEGGHWECDQEPCLVDPDMIKAINRGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDTHHQQGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPNGQVDSNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPEQYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETFVLGVWGRVGMEDMGHH sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2243 peptide sequence: MWGCWLGLLLLLLAGQAALEA mat_peptide: 22..466 product: Tubulointerstitial nephritis antigen-like experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99JR5.1) calculated_mol_wt: 50440 peptide sequence: RRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATCYCDLFCNRTVSDCCPDFWDFCLGIPPPFPPVQGCMHGGRIYPVFGTYWDNCNRCTCHEGGHWECDQEPCLVDPDMIKAINRGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDTHHQQGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPNGQVDSNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPEQYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETFVLGVWGRVGMEDMGHH
tubulointerstitial nephritis antigen-like precursor
Refseq ID NP_001161805
Protein GI 270132824
UniProt ID Q99JR5
mRNA ID NM_001168333
Length 466
RefSeq Status VALIDATED
Protein sequence is identical to GI:270132817 (mRNA isoform)

Gene Information

Entrez Gene ID
94242
Gene Name
tubulointerstitial nephritis antigen-like 1
Gene Symbol
Tinagl1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0031012 IEA:Ensembl C extracellular matrix
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0008234 IEA:InterPro F cysteine-type peptidase activity
GO:0043236 IPI:MGI F laminin binding
GO:0030247 IEA:InterPro F polysaccharide binding
GO:0005044 IEA:InterPro F scavenger receptor activity
GO:0006955 IEA:InterPro P immune response

Domain Information

InterPro Annotations

Accession Description
IPR025660 Cysteine peptidase, histidine active site
IPR000668 Peptidase C1A, papain C-terminal
IPR013128 Peptidase_C1A
IPR001212 Somatomedin B domain

UniProt Annotations

Entry Information

Gene Name
tubulointerstitial nephritis antigen-like 1
Protein Entry
TINAL_MOUSE
UniProt ID
Q99JR5
Species
Mouse

Comments

Comment Type Description
Function May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. {ECO:0000269|PubMed:12600995}.
Induction Down-regulated in prostate after castration. {ECO:0000269|PubMed:11377975}.
Ptm Glycosylated. {ECO:0000250}.
Sequence Caution Sequence=BAB20596.1; Type=Frameshift; Positions=43; Evidence={ECO:0000305};
Similarity Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-ProRule:PRU10089}.
Similarity Contains 1 SMB (somatomedin-B) domain. {ECO:0000305}.
Subcellular Location Secreted.
Tissue Specificity Highly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level). {ECO:0000269|PubMed:11377975, ECO:0000269|PubMed:12600995}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004523 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
270132817 RefSeq NP_075965 466 tubulointerstitial nephritis antigen-like precursor

Identical Sequences to LMP004523 proteins

Reference Database Accession Length Protein Name
GI:270132817 DBBJ BAC76038.1 466 tubulointersititial nephritis antigen-related protein [Mus musculus]
GI:270132817 GenBank AAH18539.1 466 Tinagl1 protein [Mus musculus]
GI:270132817 GenBank EDL30144.1 466 tubulointerstitial nephritis antigen-like, isoform CRA_a [Mus musculus]
GI:270132817 GenBank EDL30145.1 466 tubulointerstitial nephritis antigen-like, isoform CRA_a [Mus musculus]
GI:270132817 RefSeq NP_001161805.1 466 tubulointerstitial nephritis antigen-like precursor [Mus musculus]
GI:270132817 SwissProt Q99JR5.1 466 RecName: Full=Tubulointerstitial nephritis antigen-like; AltName: Full=Adrenocortical zonation factor 1; Short=AZ-1; AltName: Full=Androgen-regulated gene 1 protein; AltName: Full=Tubulointerstitial nephritis antigen-related protein; Short=TARP; Flags: Precursor [Mus musculus]

Related Sequences to LMP004523 proteins

Reference Database Accession Length Protein Name
GI:270132817 DBBJ BAB18637.1 467 glucocorticoid-inducible protein [Rattus norvegicus]
GI:270132817 GenBank EDL80584.1 467 lipocalin 7, isoform CRA_a [Rattus norvegicus]
GI:270132817 GenBank EDL80585.1 467 lipocalin 7, isoform CRA_a [Rattus norvegicus]
GI:270132817 GenBank EDL80586.1 467 lipocalin 7, isoform CRA_a [Rattus norvegicus]
GI:270132817 RefSeq NP_446034.1 467 tubulointerstitial nephritis antigen-like precursor [Rattus norvegicus]
GI:270132817 SwissProt Q9EQT5.1 467 RecName: Full=Tubulointerstitial nephritis antigen-like; AltName: Full=Glucocorticoid-inducible protein 5; Flags: Precursor [Rattus norvegicus]