Gene/Proteome Database (LMPD)

LMPD ID
LMP004533
Gene ID
146850
Species
Homo sapiens (Human)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 6
Gene Symbol
PIK3R6
Synonyms
C17orf38; HsT41028; p84 PIKAP; p87(PIKAP); p87PIKAP
Chromosome
17
Map Location
17p13.1
Summary
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Orthologs
View orthologs and multiple alignments for PIK3R6

Proteins

phosphoinositide 3-kinase regulatory subunit 6 isoform 1
Refseq ID NP_001010855
Protein GI 58082081
UniProt ID Q5UE93
mRNA ID NM_001010855
Length 754
RefSeq Status REVIEWED
MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVERDPGKSPVLVRILLRELEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFCTRLLTLPTPYCTVALDCAIRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVDPELVSASVCSALLLEIEAAQAQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASPRRTLEHYFHAVVAALEQMASEASPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPPSIPLPSPYITFHLWTGEEQLWKELVLFLRPRSQLRLSADLEVLDLQGLRPDRELARVSVLSTDSGIERDLPTGADELPAPGSPEMERAGLQRKGGIKKRAWPLDFLMPGSWDGPPGLHRRTGRPSGDGEMLPGVSRLHTARVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLAPEKPAASRQPELGELATFLGRVDPWYQSNVNTLCPAIHKLAEMPPSLDTSRTVDPFILDVITYYIRMGTQPIYFQIYTVKIFFSDLSQDPTEDIFLIELKVKIQDSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLSHRPREVTVSLRATGLILKAIPASDTEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLAGKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSKAPWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ
phosphoinositide 3-kinase regulatory subunit 6 isoform 2
Refseq ID NP_001277140
Protein GI 58082081
UniProt ID B3KRK9
mRNA ID NM_001290211
Length 754
RefSeq Status REVIEWED
MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVERDPGKSPVLVRILLRELEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFCTRLLTLPTPYCTVALDCAIRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVDPELVSASVCSALLLEIEAAQAQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASPRRTLEHYFHAVVAALEQMASEASPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPPSIPLPSPYITFHLWTGEEQLWKELVLFLRPRSQLRLSADLEVLDLQGLRPDRELARVSVLSTDSGIERDLPTGADELPAPGSPEMERAGLQRKGGIKKRAWPLDFLMPGSWDGPPGLHRRTGRPSGDGEMLPGVSRLHTARVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLAPEKPAASRQPELGELATFLGRVDPWYQSNVNTLCPAIHKLAEMPPSLDTSRTVDPFILDVITYYIRMGTQPIYFQIYTVKIFFSDLSQDPTEDIFLIELKVKIQDSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLSHRPREVTVSLRATGLILKAIPASDTEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLAGKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSKAPWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ

Gene Information

Entrez Gene ID
146850
Gene Name
phosphoinositide-3-kinase, regulatory subunit 6
Gene Symbol
PIK3R6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005944 IEA:InterPro C phosphatidylinositol 3-kinase complex, class IB
GO:0046935 IEA:InterPro F 1-phosphatidylinositol-3-kinase regulator activity
GO:0016301 IEA:UniProtKB-KW F kinase activity

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6352 3-phosphoinositide biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19290 G beta:gamma signalling through PI3Kgamma
REACT_1695 GPVI-mediated activation cascade
REACT_121025 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 6
Protein Entry
B3KRK9_HUMAN
UniProt ID
Q5UE93
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP004533 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58082081 RefSeq NP_001010855 754 phosphoinositide 3-kinase regulatory subunit 6 isoform 1
58082081 RefSeq NP_001277140 754 phosphoinositide 3-kinase regulatory subunit 6 isoform 2

Identical Sequences to LMP004533 proteins

Reference Database Accession Length Protein Name
GI:58082081 GenBank AAV30085.1 754 p87 phosphoinositide 3-kinase gamma adapter protein [Homo sapiens]
GI:58082081 GenBank AAV30085.1 754 p87 phosphoinositide 3-kinase gamma adapter protein [Homo sapiens]
GI:58082081 GenBank EAW90040.1 754 chromosome 17 open reading frame 38, isoform CRA_c [Homo sapiens]
GI:58082081 GenBank EAW90040.1 754 chromosome 17 open reading frame 38, isoform CRA_c [Homo sapiens]
GI:58082081 GenBank AAI66645.1 754 Phosphoinositide-3-kinase, regulatory subunit 6 [synthetic construct]
GI:58082081 GenBank AAI66645.1 754 Phosphoinositide-3-kinase, regulatory subunit 6 [synthetic construct]
GI:58082081 SwissProt Q5UE93.1 754 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 6; AltName: Full=Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; AltName: Full=p84 PI3K adapter protein; Short=p84 PIKAP; AltName: Full=p87 PI3K adapter protein; Short=p87PIKAP [Homo sapiens]
GI:58082081 SwissProt Q5UE93.1 754 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 6; AltName: Full=Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; AltName: Full=p84 PI3K adapter protein; Short=p84 PIKAP; AltName: Full=p87 PI3K adapter protein; Short=p87PIKAP [Homo sapiens]

Related Sequences to LMP004533 proteins

Reference Database Accession Length Protein Name
GI:58082081 GenBank EHH24519.1 750 hypothetical protein EGK_08183, partial [Macaca mulatta]
GI:58082081 GenBank EHH24519.1 750 hypothetical protein EGK_08183, partial [Macaca mulatta]
GI:58082081 RefSeq XP_003315643.1 754 PREDICTED: LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [Pan troglodytes]
GI:58082081 RefSeq XP_003315643.1 754 PREDICTED: LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [Pan troglodytes]
GI:58082081 RefSeq XP_003818129.1 754 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 [Pan paniscus]
GI:58082081 RefSeq XP_003818129.1 754 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 [Pan paniscus]
GI:58082081 RefSeq XP_005583228.1 777 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 [Macaca fascicularis]
GI:58082081 RefSeq XP_005583228.1 777 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 [Macaca fascicularis]
GI:58082081 RefSeq XP_008008509.1 754 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [Chlorocebus sabaeus]
GI:58082081 RefSeq XP_008008509.1 754 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [Chlorocebus sabaeus]
GI:58082081 RefSeq XP_008008510.1 754 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [Chlorocebus sabaeus]
GI:58082081 RefSeq XP_008008510.1 754 PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [Chlorocebus sabaeus]