Gene/Proteome Database (LMPD)

LMPD ID
LMP004587
Gene ID
137964
Species
Homo sapiens (Human)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 6
Gene Symbol
AGPAT6
Synonyms
1-AGPAT 6; LPAAT-zeta; LPAATZ; TSARG7
Chromosome
8
Map Location
8p11.21
Summary
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Orthologs
View orthologs and multiple alignments for AGPAT6

Proteins

glycerol-3-phosphate acyltransferase 6
Refseq ID NP_848934
Protein GI 30520329
UniProt ID Q2TU73
mRNA ID NM_178819
Length 456
RefSeq Status VALIDATED
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKSLLKIFAWATLRMERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRIALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS

Gene Information

Entrez Gene ID
137964
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 6
Gene Symbol
AGPAT6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0016746 IEA:UniProtKB-KW F transferase activity, transferring acyl groups
GO:0046339 IEA:Ensembl P diacylglycerol metabolic process
GO:0006631 IEA:Ensembl P fatty acid metabolic process
GO:0002071 IEA:Ensembl P glandular epithelial cell maturation
GO:0007595 ISS:UniProtKB P lactation
GO:0008610 ISS:UniProtKB P lipid biosynthetic process
GO:0040014 IEA:Ensembl P regulation of multicellular organism growth
GO:0019432 ISS:UniProtKB P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120906 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 6
Protein Entry
GPAT4_HUMAN
UniProt ID
Q2TU73
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP004587 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30520329 RefSeq NP_848934 456 glycerol-3-phosphate acyltransferase 6

Identical Sequences to LMP004587 proteins

Reference Database Accession Length Protein Name
GI:30520329 GenBank ADL91650.1 456 Sequence 188 from patent US 7709603
GI:30520329 GenBank ADL97731.1 456 Sequence 188 from patent US 7718770
GI:30520329 GenBank AEU55178.1 456 Sequence 188 from patent US 8063186
GI:30520329 GenBank AEU59798.1 456 Sequence 6 from patent US 8067664
GI:30520329 GenBank AHD72408.1 456 Sequence 9476 from patent US 8586006
GI:30520329 GenBank AIC53099.1 456 AGPAT6, partial [synthetic construct]

Related Sequences to LMP004587 proteins

Reference Database Accession Length Protein Name
GI:30520329 EMBL CAH92613.1 465 hypothetical protein [Pongo abelii]
GI:30520329 GenBank JAA02710.1 456 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) [Pan troglodytes]
GI:30520329 GenBank JAA15977.1 456 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) [Pan troglodytes]
GI:30520329 GenBank JAA22492.1 456 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) [Pan troglodytes]
GI:30520329 GenBank JAA42325.1 456 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) [Pan troglodytes]
GI:30520329 RefSeq NP_001126531.1 465 glycerol-3-phosphate acyltransferase 6 [Pongo abelii]