Gene/Proteome Database (LMPD)
LMPD ID
LMP004643
Gene ID
Species
Homo sapiens (Human)
Gene Name
prenylcysteine oxidase 1
Gene Symbol
Synonyms
PCL1
Alternate Names
prenylcysteine oxidase 1; prenylcysteine lyase
Chromosome
2
Map Location
2p13.3
EC Number
1.8.3.5
Summary
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Orthologs
Proteins
| prenylcysteine oxidase 1 precursor | |
|---|---|
| Refseq ID | NP_057381 |
| Protein GI | 166795301 |
| UniProt ID | Q9UHG3 |
| mRNA ID | NM_016297 |
| Length | 505 |
| RefSeq Status | VALIDATED |
| MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLLETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIILHDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEKLKTEL | |
| sig_peptide: 1..27 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2806 peptide sequence: MGRVVAELVSSLLGLWLLLCSCGCPEG mat_peptide: 28..505 product: Prenylcysteine oxidase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9UHG3.3) calculated_mol_wt: 53852 peptide sequence: AELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLLETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIILHDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEKLKTEL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0005764 | IDA:BHF-UCL | C | lysosome |
| GO:0005886 | IEA:Ensembl | C | plasma membrane |
| GO:0034361 | IDA:BHF-UCL | C | very-low-density lipoprotein particle |
| GO:0008555 | IEA:Ensembl | F | chloride-transporting ATPase activity |
| GO:0001735 | IDA:BHF-UCL | F | prenylcysteine oxidase activity |
| GO:0030327 | NAS:UniProtKB | P | prenylated protein catabolic process |
| GO:0030328 | IEA:Ensembl | P | prenylcysteine catabolic process |
| GO:0030329 | NAS:UniProtKB | P | prenylcysteine metabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UHG3-1; Sequence=Displayed; Name=2; IsoId=Q9UHG3-2; Sequence=VSP_056701; Note=No experimental confirmation available.; |
| Catalytic Activity | An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2). |
| Caution | Was originally thought to be a lyase and was therefore termed prenylcysteine lyase. |
| Cofactor | Name=FAD; Xref=ChEBI |
| Function | Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. |
| Ptm | The protein is glycosylated at one or more potential N- glycosylation sites. {ECO |
| Sequence Caution | Sequence=BAA74931.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the prenylcysteine oxidase family. |
| Subcellular Location | Lysosome. |
| Tissue Specificity | Ubiquitous. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004643 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 166795301 | RefSeq | NP_057381 | 505 | prenylcysteine oxidase 1 precursor |
Identical Sequences to LMP004643 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:166795301 | GenBank | ADL73302.1 | 505 | Sequence 450 from patent US 7696319 |
| GI:166795301 | GenBank | ADL91472.1 | 505 | Sequence 450 from patent US 7709602 |
| GI:166795301 | GenBank | ADL91782.1 | 505 | Sequence 450 from patent US 7709603 |
| GI:166795301 | GenBank | ADL97863.1 | 505 | Sequence 450 from patent US 7718770 |
| GI:166795301 | GenBank | AEU55310.1 | 505 | Sequence 450 from patent US 8063186 |
| GI:166795301 | GenBank | AIC56455.1 | 505 | PCYOX1, partial [synthetic construct] |
Related Sequences to LMP004643 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:166795301 | DBBJ | BAA74931.1 | 506 | KIAA0908 protein, partial [Homo sapiens] |
| GI:166795301 | DBBJ | BAG09897.1 | 505 | prenylcysteine oxidase precursor, partial [synthetic construct] |
| GI:166795301 | GenBank | AAF16937.1 | 505 | prenylcysteine lyase [Homo sapiens] |
| GI:166795301 | GenBank | JAA29616.1 | 505 | prenylcysteine oxidase 1 [Pan troglodytes] |
| GI:166795301 | GenBank | JAA29617.1 | 505 | prenylcysteine oxidase 1 [Pan troglodytes] |
| GI:166795301 | GenBank | JAA35239.1 | 505 | prenylcysteine oxidase 1 [Pan troglodytes] |