Gene/Proteome Database (LMPD)
LMPD ID
LMP004643
Gene ID
Species
Homo sapiens (Human)
Gene Name
prenylcysteine oxidase 1
Gene Symbol
Synonyms
PCL1
Alternate Names
prenylcysteine oxidase 1; prenylcysteine lyase
Chromosome
2
Map Location
2p13.3
EC Number
1.8.3.5
Summary
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Orthologs
Proteins
prenylcysteine oxidase 1 precursor | |
---|---|
Refseq ID | NP_057381 |
Protein GI | 166795301 |
UniProt ID | Q9UHG3 |
mRNA ID | NM_016297 |
Length | 505 |
RefSeq Status | VALIDATED |
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLLETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIILHDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEKLKTEL | |
sig_peptide: 1..27 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2806 peptide sequence: MGRVVAELVSSLLGLWLLLCSCGCPEG mat_peptide: 28..505 product: Prenylcysteine oxidase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9UHG3.3) calculated_mol_wt: 53852 peptide sequence: AELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLLETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIILHDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEKLKTEL |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
GO:0005764 | IDA:BHF-UCL | C | lysosome |
GO:0005886 | IEA:Ensembl | C | plasma membrane |
GO:0034361 | IDA:BHF-UCL | C | very-low-density lipoprotein particle |
GO:0008555 | IEA:Ensembl | F | chloride-transporting ATPase activity |
GO:0001735 | IDA:BHF-UCL | F | prenylcysteine oxidase activity |
GO:0030327 | NAS:UniProtKB | P | prenylated protein catabolic process |
GO:0030328 | IEA:Ensembl | P | prenylcysteine catabolic process |
GO:0030329 | NAS:UniProtKB | P | prenylcysteine metabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UHG3-1; Sequence=Displayed; Name=2; IsoId=Q9UHG3-2; Sequence=VSP_056701; Note=No experimental confirmation available.; |
Catalytic Activity | An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2). |
Caution | Was originally thought to be a lyase and was therefore termed prenylcysteine lyase. |
Cofactor | Name=FAD; Xref=ChEBI |
Function | Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. |
Ptm | The protein is glycosylated at one or more potential N- glycosylation sites. {ECO |
Sequence Caution | Sequence=BAA74931.1; Type=Erroneous initiation; Evidence= ; |
Similarity | Belongs to the prenylcysteine oxidase family. |
Subcellular Location | Lysosome. |
Tissue Specificity | Ubiquitous. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004643 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
166795301 | RefSeq | NP_057381 | 505 | prenylcysteine oxidase 1 precursor |
Identical Sequences to LMP004643 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:166795301 | GenBank | ADL73302.1 | 505 | Sequence 450 from patent US 7696319 |
GI:166795301 | GenBank | ADL91472.1 | 505 | Sequence 450 from patent US 7709602 |
GI:166795301 | GenBank | ADL91782.1 | 505 | Sequence 450 from patent US 7709603 |
GI:166795301 | GenBank | ADL97863.1 | 505 | Sequence 450 from patent US 7718770 |
GI:166795301 | GenBank | AEU55310.1 | 505 | Sequence 450 from patent US 8063186 |
GI:166795301 | GenBank | AIC56455.1 | 505 | PCYOX1, partial [synthetic construct] |
Related Sequences to LMP004643 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:166795301 | DBBJ | BAA74931.1 | 506 | KIAA0908 protein, partial [Homo sapiens] |
GI:166795301 | DBBJ | BAG09897.1 | 505 | prenylcysteine oxidase precursor, partial [synthetic construct] |
GI:166795301 | GenBank | AAF16937.1 | 505 | prenylcysteine lyase [Homo sapiens] |
GI:166795301 | GenBank | JAA29616.1 | 505 | prenylcysteine oxidase 1 [Pan troglodytes] |
GI:166795301 | GenBank | JAA29617.1 | 505 | prenylcysteine oxidase 1 [Pan troglodytes] |
GI:166795301 | GenBank | JAA35239.1 | 505 | prenylcysteine oxidase 1 [Pan troglodytes] |