Gene/Proteome Database (LMPD)

LMPD ID
LMP004657
Gene ID
64129
Species
Homo sapiens (Human)
Gene Name
tubulointerstitial nephritis antigen-like 1
Gene Symbol
TINAGL1
Synonyms
ARG1; LCN7; LIECG3; TINAGRP
Alternate Names
tubulointerstitial nephritis antigen-like; OLRG-2; P3ECSL; TIN-Ag-RP; lipocalin 7; TINAG-like 1; TIN Ag-related protein; androgen-regulated gene 1; oxidized-LDL responsive gene 2; glucocorticoid-inducible protein 5; tubulointerstitial nephritis antigen-related protein
Chromosome
1
Map Location
1p35.2
Summary
The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Orthologs
View orthologs and multiple alignments for TINAGL1

Proteins

tubulointerstitial nephritis antigen-like isoform 1 precursor
Refseq ID NP_071447
Protein GI 11545918
UniProt ID Q9GZM7
mRNA ID NM_022164
Length 467
RefSeq Status REVIEWED
MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2258 peptide sequence: MWRCPLGLLLLLPLAGHLALG mat_peptide: 22..436 product: tubulointerstitial nephritis antigen-like isoform 2 calculated_mol_wt: 46568 peptide sequence: AQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2258 peptide sequence: MWRCPLGLLLLLPLAGHLALG mat_peptide: 22..467 product: Tubulointerstitial nephritis antigen-like experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9GZM7.1) calculated_mol_wt: 50148 peptide sequence: AQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
tubulointerstitial nephritis antigen-like isoform 2 precursor
Refseq ID NP_001191343
Protein GI 324711034
UniProt ID Q9GZM7
mRNA ID NM_001204414
Length 436
RefSeq Status REVIEWED
MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
tubulointerstitial nephritis antigen-like isoform 3
Refseq ID NP_001191344
Protein GI 324713036
UniProt ID Q9GZM7
mRNA ID NM_001204415
Length 362
RefSeq Status REVIEWED
MHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH

Gene Information

Entrez Gene ID
64129
Gene Name
tubulointerstitial nephritis antigen-like 1
Gene Symbol
TINAGL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005576 NAS:UniProtKB C extracellular region
GO:0005615 ISS:BHF-UCL C extracellular space
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0008234 IEA:InterPro F cysteine-type peptidase activity
GO:0005201 NAS:UniProtKB F extracellular matrix structural constituent
GO:0030247 IEA:InterPro F polysaccharide binding
GO:0005044 IEA:InterPro F scavenger receptor activity
GO:0016197 TAS:UniProtKB P endosomal transport
GO:0006955 IEA:InterPro P immune response

Domain Information

InterPro Annotations

Accession Description
IPR025660 Cysteine peptidase, histidine active site
IPR000668 Peptidase C1A, papain C-terminal
IPR013128 Peptidase_C1A
IPR001212 Somatomedin B domain

UniProt Annotations

Entry Information

Gene Name
tubulointerstitial nephritis antigen-like 1
Protein Entry
TINAL_HUMAN
UniProt ID
Q9GZM7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9GZM7-1; Sequence=Displayed; Name=2; IsoId=Q9GZM7-2; Sequence=VSP_013094, VSP_013095, VSP_013096, VSP_013097, VSP_013098; Name=3; IsoId=Q9GZM7-3; Sequence=VSP_043712; Note=No experimental confirmation available.;
Function May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).
Ptm Glycosylated. {ECO
Sequence Caution Sequence=AAH09048.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB55403.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the peptidase C1 family.
Similarity Contains 1 SMB (somatomedin-B) domain.
Subcellular Location Secreted {ECO
Tissue Specificity Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP004657 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11545918 RefSeq NP_071447 467 tubulointerstitial nephritis antigen-like isoform 1 precursor
324711034 RefSeq NP_001191343 436 tubulointerstitial nephritis antigen-like isoform 2 precursor
324713036 RefSeq NP_001191344 362 tubulointerstitial nephritis antigen-like isoform 3

Identical Sequences to LMP004657 proteins

Reference Database Accession Length Protein Name
GI:324711034 DBBJ BAG60618.1 436 unnamed protein product [Homo sapiens]
GI:324713036 GenBank EAX07603.1 362 tubulointerstitial nephritis antigen-like 1, isoform CRA_a [Homo sapiens]
GI:324713036 GenBank ADA20308.1 362 Sequence 2132 from patent US 7608413
GI:324713036 GenBank AEN36204.1 362 Sequence 2132 from patent US 7998689
GI:11545918 GenBank JAA20666.1 467 tubulointerstitial nephritis antigen-like 1 [Pan troglodytes]
GI:11545918 GenBank JAA32380.1 467 tubulointerstitial nephritis antigen-like 1 [Pan troglodytes]
GI:11545918 GenBank JAA32381.1 467 tubulointerstitial nephritis antigen-like 1 [Pan troglodytes]
GI:11545918 GenBank JAA32382.1 467 tubulointerstitial nephritis antigen-like 1 [Pan troglodytes]
GI:11545918 GenBank JAA36571.1 467 tubulointerstitial nephritis antigen-like 1 [Pan troglodytes]
GI:11545918 GenBank AIC52116.1 467 TINAGL1, partial [synthetic construct]
GI:324713036 RefSeq XP_005271164.1 362 PREDICTED: tubulointerstitial nephritis antigen-like isoform X2 [Homo sapiens]

Related Sequences to LMP004657 proteins

Reference Database Accession Length Protein Name
GI:324713036 DBBJ BAB18636.1 467 glucocorticoid-inducible protein [Homo sapiens]
GI:324711034 DBBJ BAB18636.1 467 glucocorticoid-inducible protein [Homo sapiens]
GI:324713036 DBBJ BAB18727.1 467 glucocorticoid-inducible protein [Homo sapiens]
GI:324711034 DBBJ BAB18727.1 467 glucocorticoid-inducible protein [Homo sapiens]
GI:324713036 GenBank AAG33699.1 467 oxidized-LDL responsive gene 2 [Homo sapiens]
GI:324711034 GenBank AAG33699.1 467 oxidized-LDL responsive gene 2 [Homo sapiens]
GI:324711034 GenBank AAG38876.1 467 tubulointerstitial nephritis antigen-related protein precursor [Homo sapiens]
GI:324713036 GenBank AAG38876.1 467 tubulointerstitial nephritis antigen-related protein precursor [Homo sapiens]
GI:324713036 GenBank AAG40154.1 467 tubulointerstitial nephritis antigen-related protein [Homo sapiens]
GI:11545918 GenBank EHH49712.1 467 hypothetical protein EGM_00421 [Macaca fascicularis]
GI:11545918 GenBank AFI37980.1 467 tubulointerstitial nephritis antigen-like isoform 1 precursor [Macaca mulatta]
GI:324711034 RefSeq NP_071447.1 467 tubulointerstitial nephritis antigen-like isoform 1 precursor [Homo sapiens]
GI:324713036 RefSeq NP_071447.1 467 tubulointerstitial nephritis antigen-like isoform 1 precursor [Homo sapiens]
GI:11545918 RefSeq XP_002811184.1 467 PREDICTED: tubulointerstitial nephritis antigen-like [Pongo abelii]
GI:11545918 RefSeq XP_003276396.1 467 PREDICTED: tubulointerstitial nephritis antigen-like isoform 1 [Nomascus leucogenys]
GI:324711034 RefSeq XP_003276397.1 436 PREDICTED: tubulointerstitial nephritis antigen-like isoform 2 [Nomascus leucogenys]
GI:11545918 RefSeq XP_003828174.1 467 PREDICTED: tubulointerstitial nephritis antigen-like isoform X1 [Pan paniscus]
GI:11545918 RefSeq XP_009450949.1 467 PREDICTED: tubulointerstitial nephritis antigen-like [Pan troglodytes]