Gene/Proteome Database (LMPD)
LMPD ID
LMP004658
Gene ID
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor coactivator 2
Gene Symbol
Synonyms
D1Ertd433e; GRIP-1; Grip1; KAT13C; NCoA-2; SRC-2; TIF2; bHLHe75
Alternate Names
nuclear receptor coactivator 2; steroid receptor coactivator 2; transcriptional intermediary factor 2; glucocorticoid receptor interacting protein 1
Chromosome
1
Map Location
1 A3-A5|1 4.12 cM
Proteins
| nuclear receptor coactivator 2 isoform a | |
|---|---|
| Refseq ID | NP_032704 |
| Protein GI | 118026940 |
| UniProt ID | Q61026 |
| mRNA ID | NM_008678 |
| Length | 1462 |
| RefSeq Status | VALIDATED |
| MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWSGEPPRRSSHTFNCRMLVKPLPDSEEEGHDSQEAHQKYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPTLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMGKPLNPISSSSPAHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGDRAEGHSRLHDSKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPAVRVTCAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQGGYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISSVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRTLMMRGQGLNVTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPTSDMNGWAQGSMGGNSMFSQQSPPHFGQQANTSMYSNNMNISVSMATNTGGLSSMNQMTGQMSMTSVTSVPTSGLPSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDASRKYC | |
Gene Information
Entrez Gene ID
Gene Name
nuclear receptor coactivator 2
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:MGI | C | cytoplasm |
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | IDA:MGI | C | nucleus |
| GO:0003682 | IDA:MGI | F | chromatin binding |
| GO:0004402 | IEA:InterPro | F | histone acetyltransferase activity |
| GO:0030374 | IDA:MGI | F | ligand-dependent nuclear receptor transcription coactivator activity |
| GO:0005102 | IDA:MGI | F | receptor binding |
| GO:0004871 | IEA:InterPro | F | signal transducer activity |
| GO:0030375 | IDA:MGI | F | thyroid hormone receptor coactivator activity |
| GO:0003713 | IDA:UniProtKB | F | transcription coactivator activity |
| GO:0008134 | IPI:UniProtKB | F | transcription factor binding |
| GO:0000122 | IDA:MGI | P | negative regulation of transcription from RNA polymerase II promoter |
| GO:0045892 | IDA:MGI | P | negative regulation of transcription, DNA-templated |
| GO:2000273 | IDA:GOC | P | positive regulation of receptor activity |
| GO:0045944 | IGI:MGI | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0010906 | IMP:UniProtKB | P | regulation of glucose metabolic process |
| GO:0006355 | IDA:MGI | P | regulation of transcription, DNA-templated |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu04919 | Thyroid hormone signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 442533 | Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR010011 | Domain of unknown function DUF1518 |
| IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| IPR017426 | Nuclear receptor coactivator |
| IPR028822 | Nuclear receptor coactivator 2 |
| IPR008955 | Nuclear receptor coactivator Src-1 |
| IPR014920 | Nuclear receptor coactivator, Ncoa-type, interlocking |
| IPR009110 | Nuclear receptor coactivator, interlocking |
| IPR001610 | PAC motif |
| IPR000014 | PAS domain |
| IPR013767 | PAS_fold |
| IPR014935 | Steroid receptor coactivator |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disruption Phenotype | Animals show a glycogenopathy resembling to Von Gierke's disease with impaired growth, fasting hypoglycemia, and an increase in concentrations of triglycerides, cholesterol, free fatty acids, ketone bodies, uric acid and lactic acid in the plasma during fating. They also have increased liver glycogen stores and hepatic steatosis. {ECO:0000269|PubMed:19039140}. |
| Domain | Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently. {ECO:0000250}. |
| Domain | Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (PubMed:16148126). {ECO:0000269|PubMed:16148126}. |
| Domain | The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding. {ECO:0000250}. |
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. {ECO:0000269|PubMed:11997499, ECO:0000269|PubMed:12507421, ECO:0000269|PubMed:16148126, ECO:0000269|PubMed:19039140}. |
| Sequence Caution | Sequence=AAB61575.1; Type=Frameshift; Positions=251, 256, 302, 321, 959, 964, 983; Evidence={ECO:0000305}; |
| Similarity | Belongs to the SRC/p160 nuclear receptor coactivator family. {ECO:0000305}. |
| Similarity | Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule:PRU00140}. |
| Similarity | Contains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Subcellular Location | Nucleus. |
| Subunit | Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. {ECO:0000269|PubMed:10381882, ECO:0000269|PubMed:11997499, ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:16148126, ECO:0000269|PubMed:19039140, ECO:0000269|PubMed:9111344}. |
| Tissue Specificity | Ubiquitous. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004658 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 118026940 | RefSeq | NP_032704 | 1462 | nuclear receptor coactivator 2 isoform a |
Identical Sequences to LMP004658 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:118026940 | RefSeq | XP_006495528.1 | 1462 | PREDICTED: nuclear receptor coactivator 2 isoform X1 [Mus musculus] |
| GI:118026940 | RefSeq | XP_006495529.1 | 1462 | PREDICTED: nuclear receptor coactivator 2 isoform X2 [Mus musculus] |
| GI:118026940 | RefSeq | XP_006495530.1 | 1462 | PREDICTED: nuclear receptor coactivator 2 isoform X3 [Mus musculus] |
| GI:118026940 | RefSeq | XP_006495531.1 | 1462 | PREDICTED: nuclear receptor coactivator 2 isoform X4 [Mus musculus] |
| GI:118026940 | SwissProt | Q61026.3 | 1462 | RecName: Full=Nuclear receptor coactivator 2; Short=NCoA-2; AltName: Full=Glucocorticoid receptor-interacting protein 1; Short=GRIP-1; AltName: Full=Steroid receptor coactivator 2; Short=SRC-2; AltName: Full=Transcriptional intermediary factor 2 [Mus musculus] |
Related Sequences to LMP004658 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:118026940 | GenBank | AAC53151.1 | 1462 | glucocorticoid receptor interacting protein 1 [Mus musculus] |
| GI:118026940 | GenBank | AFQ82095.1 | 1462 | Sequence 11 from patent US 8247168 |
| GI:118026940 | RefSeq | XP_005361937.1 | 1464 | PREDICTED: nuclear receptor coactivator 2 [Microtus ochrogaster] |
| GI:118026940 | RefSeq | XP_006237807.1 | 1465 | PREDICTED: nuclear receptor coactivator 2 isoform X1 [Rattus norvegicus] |
| GI:118026940 | RefSeq | XP_006237809.1 | 1465 | PREDICTED: nuclear receptor coactivator 2 isoform X1 [Rattus norvegicus] |
| GI:118026940 | RefSeq | XP_006974758.1 | 1464 | PREDICTED: nuclear receptor coactivator 2 [Peromyscus maniculatus bairdii] |