Gene/Proteome Database (LMPD)
Proteins
| ras-related GTP-binding protein C | |
|---|---|
| Refseq ID | NP_059503 |
| Protein GI | 114145487 |
| UniProt ID | Q99K70 |
| mRNA ID | NM_017475 |
| Length | 398 |
| RefSeq Status | VALIDATED |
| MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALAHNGTPRNAI | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | ISS:HGNC | C | cytoplasm |
| GO:0005764 | ISS:UniProtKB | C | lysosome |
| GO:0005634 | ISS:HGNC | C | nucleus |
| GO:0019003 | ISS:UniProtKB | F | GDP binding |
| GO:0005525 | ISS:HGNC | F | GTP binding |
| GO:0003924 | ISS:UniProtKB | F | GTPase activity |
| GO:0046982 | ISS:UniProtKB | F | protein heterodimerization activity |
| GO:0006184 | ISS:GOC | P | GTP catabolic process |
| GO:0032008 | ISS:UniProtKB | P | positive regulation of TOR signaling |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q99K70-1; Sequence=Displayed; Name=2 ; IsoId=Q99K70-2; Sequence=VSP_052076, VSP_052077; Note=No experimental confirmation available. ; |
| Function | Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity). |
| Sequence Caution | Sequence=BAA75671.1; Type=Frameshift; Positions=19, 56, 68, 71; Evidence= ; |
| Similarity | Belongs to the GTR/RAG GTP-binding protein family. |
| Subcellular Location | Cytoplasm . Nucleus {ECO:0000250}. Lysosome . Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (By similarity). |
| Subunit | Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (By similarity). |
| Tissue Specificity | Expressed most abundantly in kidney. Moderately expressed in brain, ovary, and testis, and detected at lower levels in heart, liver, and muscle. Not detected in lung, spleen, and small intestine. Widely expressed in tumor cells, with expression being specifically up-regulated in highly metastatic cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004667 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 114145487 | RefSeq | NP_059503 | 398 | ras-related GTP-binding protein C |
Identical Sequences to LMP004667 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:114145487 | DBBJ | BAE35013.1 | 398 | unnamed protein product [Mus musculus] |
| GI:114145487 | GenBank | AAH05417.1 | 398 | Ras-related GTP binding C [Mus musculus] |
| GI:114145487 | RefSeq | XP_005084408.1 | 398 | PREDICTED: ras-related GTP-binding protein C isoform X1 [Mesocricetus auratus] |
| GI:114145487 | RefSeq | XP_006997308.1 | 398 | PREDICTED: ras-related GTP-binding protein C [Peromyscus maniculatus bairdii] |
| GI:114145487 | SwissProt | Q99K70.1 | 398 | RecName: Full=Ras-related GTP-binding protein C; Short=Rag C; Short=RagC; AltName: Full=GTPase-interacting protein 2; AltName: Full=TIB929 [Mus musculus] |
Related Sequences to LMP004667 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:114145487 | GenBank | AAI19865.1 | 399 | Ras-related GTP binding C [Bos taurus] |
| GI:114145487 | GenBank | AAI05623.1 | 398 | Ras-related GTP binding C [Rattus norvegicus] |
| GI:114145487 | RefSeq | NP_001041649.1 | 398 | ras-related GTP-binding protein C [Rattus norvegicus] |
| GI:114145487 | RefSeq | XP_003127849.1 | 399 | PREDICTED: ras-related GTP-binding protein C isoform X1 [Sus scrofa] |
| GI:114145487 | RefSeq | XP_005353335.1 | 398 | PREDICTED: ras-related GTP-binding protein C isoform X1 [Microtus ochrogaster] |
| GI:114145487 | RefSeq | XP_008848450.1 | 398 | PREDICTED: ras-related GTP-binding protein C [Nannospalax galili] |