Gene/Proteome Database (LMPD)

LMPD ID
LMP004697
Gene ID
27052
Species
Mus musculus (Mouse)
Gene Name
acyloxyacyl hydrolase
Gene Symbol
Aoah
Synonyms
4930433E13Rik
Alternate Names
acyloxyacyl hydrolase
Chromosome
13
Map Location
13 A2|13
EC Number
3.1.1.77
Summary
This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]
Orthologs
View orthologs and multiple alignments for Aoah

Proteins

acyloxyacyl hydrolase isoform 1 preproprotein
Refseq ID NP_036184
Protein GI 6753064
UniProt ID O35298
mRNA ID NM_012054
Length 574
RefSeq Status REVIEWED
MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSGRNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEEVFGDQGGH
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2587 peptide sequence: MKFPWKVFKTTLLLLLLSHSLA sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2587 peptide sequence: MKFPWKVFKTTLLLLLLSHSLA mat_peptide: 34..155 product: acyloxyacyl hydrolase small subunit calculated_mol_wt: 13749 peptide sequence: YSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSG mat_peptide: 156..574 product: acyloxyacyl hydrolase large subunit calculated_mol_wt: 47756 peptide sequence: RNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEEVFGDQGGH
acyloxyacyl hydrolase isoform 2 preproprotein
Refseq ID NP_001268783
Protein GI 529367294
UniProt ID O35298
mRNA ID NM_001281854
Length 145
RefSeq Status REVIEWED
MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQDNQLISRCPERFRDQY

Gene Information

Entrez Gene ID
27052
Gene Name
acyloxyacyl hydrolase
Gene Symbol
Aoah
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0050528 IDA:MGI F acyloxyacyl hydrolase activity
GO:0008653 IDA:MGI P lipopolysaccharide metabolic process
GO:0050728 IDA:MGI P negative regulation of inflammatory response

Domain Information

InterPro Annotations

Accession Description
IPR001087 Lipase, GDSL
IPR008139 Saposin B
IPR011001 Saposin-like
IPR008138 Saposin-like type B, 2

UniProt Annotations

Entry Information

Gene Name
acyloxyacyl hydrolase
Protein Entry
AOAH_MOUSE
UniProt ID
O35298
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 3-(acyloxy)acyl group of bacterial toxin = 3- hydroxyacyl group of bacterial toxin + a fatty acid.
Function Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. {ECO:0000250}.
Ptm Both subunits contain a number of cysteine residues that may form disulfide bridges. {ECO:0000250}.
Similarity Contains 1 saposin B-type domain. {ECO:0000255|PROSITE-ProRule:PRU00415}.
Subcellular Location Secreted {ECO:0000250}.
Subunit Heterodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004697 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6753064 RefSeq NP_036184 574 acyloxyacyl hydrolase isoform 1 preproprotein
529367294 RefSeq NP_001268783 145 acyloxyacyl hydrolase isoform 2 preproprotein

Identical Sequences to LMP004697 proteins

Reference Database Accession Length Protein Name
GI:6753064 DBBJ BAC39187.1 574 unnamed protein product [Mus musculus]
GI:529367294 DBBJ BAE29933.1 145 unnamed protein product [Mus musculus]
GI:529367294 DBBJ BAE31141.1 145 unnamed protein product [Mus musculus]
GI:6753064 GenBank AAB81182.1 574 acyloxyacyl hydrolase [Mus musculus]
GI:529367294 GenBank AAH89580.1 145 Aoah protein [Mus musculus]
GI:6753064 SwissProt O35298.1 574 RecName: Full=Acyloxyacyl hydrolase; Contains: RecName: Full=Acyloxyacyl hydrolase small subunit; Contains: RecName: Full=Acyloxyacyl hydrolase large subunit; Flags: Precursor [Mus musculus]

Related Sequences to LMP004697 proteins

Reference Database Accession Length Protein Name
GI:529367294 DBBJ BAC39187.1 574 unnamed protein product [Mus musculus]
GI:6753064 DBBJ BAE42533.1 574 unnamed protein product [Mus musculus]
GI:6753064 DBBJ BAE21600.1 574 unnamed protein product [Mus musculus]
GI:529367294 DBBJ BAE21600.1 574 unnamed protein product [Mus musculus]
GI:6753064 EMBL CAJ18450.1 574 Aoah [Mus musculus]
GI:529367294 EMBL CAJ18450.1 574 Aoah [Mus musculus]
GI:529367294 GenBank AAB81182.1 574 acyloxyacyl hydrolase [Mus musculus]
GI:6753064 GenBank EDL32676.1 574 acyloxyacyl hydrolase [Mus musculus]
GI:6753064 GenBank AAI50768.1 574 Acyloxyacyl hydrolase [Mus musculus]
GI:529367294 RefSeq NP_036184.1 574 acyloxyacyl hydrolase isoform 1 preproprotein [Mus musculus]
GI:6753064 RefSeq XP_006516743.1 549 PREDICTED: acyloxyacyl hydrolase isoform X1 [Mus musculus]
GI:529367294 SwissProt O35298.1 574 RecName: Full=Acyloxyacyl hydrolase; Contains: RecName: Full=Acyloxyacyl hydrolase small subunit; Contains: RecName: Full=Acyloxyacyl hydrolase large subunit; Flags: Precursor [Mus musculus]