Gene/Proteome Database (LMPD)

LMPD ID
LMP004721
Gene ID
15502
Species
Mus musculus (Mouse)
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
Dnaja1
Synonyms
Hsj2; Nedd7
Alternate Names
dnaJ homolog subfamily A member 1; HSJ-2; heat shock protein J2; dnaJ protein homolog 2; heat shock 40 kDa protein 4; heat shock protein, Dnaj-like 2; neural precursor cell expressed, developmentally down-regulated gene 7
Chromosome
4
Map Location
4 A5|4

Proteins

dnaJ homolog subfamily A member 1
Refseq ID NP_001158143
Protein GI 258547146
UniProt ID P63037
mRNA ID NM_001164671
Length 397
RefSeq Status VALIDATED
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
dnaJ homolog subfamily A member 1
Refseq ID NP_001158144
Protein GI 258547148
UniProt ID P63037
mRNA ID NM_001164672
Length 397
RefSeq Status VALIDATED
Protein sequence is identical to GI:258547146 (mRNA isoform)
dnaJ homolog subfamily A member 1
Refseq ID NP_032324
Protein GI 6680297
UniProt ID P63037
mRNA ID NM_008298
Length 397
RefSeq Status VALIDATED
Protein sequence is identical to GI:258547146 (mRNA isoform)
mat_peptide: 1..394 product: DnaJ homolog subfamily A member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P63037.1) calculated_mol_wt: 44552 peptide sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC mat_peptide: 1..394 product: DnaJ homolog subfamily A member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P63037.1) calculated_mol_wt: 44552 peptide sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC mat_peptide: 1..394 product: DnaJ homolog subfamily A member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P63037.1) calculated_mol_wt: 44552 peptide sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC

Gene Information

Entrez Gene ID
15502
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
Dnaja1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:InterPro F ATP binding
GO:0030544 ISS:UniProtKB F Hsp70 protein binding
GO:0051087 ISS:UniProtKB F chaperone binding
GO:0050750 ISO:MGI F low-density lipoprotein particle receptor binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0042769 IEA:Ensembl P DNA damage response, detection of DNA damage
GO:0030521 IMP:MGI P androgen receptor signaling pathway
GO:0043508 ISS:UniProtKB P negative regulation of JUN kinase activity
GO:0043066 ISS:UniProtKB P negative regulation of apoptotic process
GO:0043065 ISS:UniProtKB P positive regulation of apoptotic process
GO:0006457 IEA:InterPro P protein folding
GO:0070585 ISS:UniProtKB P protein localization to mitochondrion
GO:0051223 ISS:UniProtKB P regulation of protein transport
GO:0009408 IEA:InterPro P response to heat
GO:0030317 IMP:MGI P sperm motility
GO:0007283 IMP:MGI P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko04141 Protein processing in endoplasmic reticulum
mmu04141 Protein processing in endoplasmic reticulum

Domain Information

InterPro Annotations

Accession Description
IPR012724 Chaperone DnaJ
IPR002939 Chaperone DnaJ, C-terminal
IPR018253 DnaJ domain, conserved site
IPR001623 DnaJ_domain
IPR008971 HSP40/DnaJ peptide-binding
IPR001305 Heat shock protein DnaJ, cysteine-rich domain

UniProt Annotations

Entry Information

Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Protein Entry
DNJA1_MOUSE
UniProt ID
P63037
Species
Mouse

Comments

Comment Type Description
Function Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. {ECO:0000250, ECO:0000269|PubMed:14752510}.
Similarity Contains 1 CR-type zinc finger. {ECO:0000305}.
Similarity Contains 1 J domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {ECO:0000250}.
Subunit Identified in a complex with HSPA1B and BAX. {ECO:0000269|PubMed:14752510}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004721 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
258547146 RefSeq NP_001158143 397 dnaJ homolog subfamily A member 1

Identical Sequences to LMP004721 proteins

Reference Database Accession Length Protein Name
GI:258547146 GenBank EDL05433.1 397 mCG9817, isoform CRA_a [Mus musculus]
GI:258547146 GenBank EDL05434.1 397 mCG9817, isoform CRA_a [Mus musculus]
GI:258547146 GenBank EDL98641.1 397 DnaJ (Hsp40) homolog, subfamily A, member 1 [Rattus norvegicus]
GI:258547146 GenBank AAI58025.1 397 DnaJ (Hsp40) homolog, subfamily A, member 1 [Mus musculus]
GI:258547146 RefSeq NP_001158144.1 397 dnaJ homolog subfamily A member 1 [Mus musculus]
GI:258547146 RefSeq XP_006238161.1 397 PREDICTED: dnaJ homolog subfamily A member 1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP004721 proteins

Reference Database Accession Length Protein Name
GI:258547146 DBBJ BAE39284.1 397 unnamed protein product [Mus musculus]
GI:258547146 GenBank AAE40475.1 397 Sequence 5 from patent US 6001598
GI:258547146 GenBank ABW03357.1 397 DnaJ (Hsp40) homolog, subfamily A, member 1, partial [synthetic construct]
GI:258547146 GenBank AED04407.1 397 Sequence 50 from patent US 7872173
GI:258547146 RefSeq XP_008840705.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Nannospalax galili]
GI:258547146 RefSeq XP_008840706.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Nannospalax galili]