Gene/Proteome Database (LMPD)

LMPD ID
LMP004732
Gene ID
503610
Species
Mus musculus (Mouse)
Gene Name
zinc finger, DHHC domain containing 18
Gene Symbol
Zdhhc18
Synonyms
-
Alternate Names
palmitoyltransferase ZDHHC18; DHHC-18; zinc finger DHHC domain-containing protein 18
Chromosome
4
Map Location
4 D2.3|4
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC18
Refseq ID NP_001017968
Protein GI 114326532
UniProt ID Q5Y5T2
mRNA ID NM_001017968
Length 380
RefSeq Status VALIDATED
MKDCEYQQISPGAAPPPASPGARRPGPAAPPAPSPGPAPGAPRWSGSGSGSGSLGRRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLILSTTILFFVFDCPYLARTLTLAIPIIAAILFFFVMSCLLQTSFTDPGILPRATICEAAALEKQIDNTGSSTYRPPPRTREVMINGQTVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLLSQGSNFLSALKKTPASVLELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKSIITNCCAVLCGPLPPSLIDRRGFVQSDTALPSPIRSDDPACGAKPDASMVGGHP

Gene Information

Entrez Gene ID
503610
Gene Name
zinc finger, DHHC domain containing 18
Gene Symbol
Zdhhc18
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016409 IDA:MGI F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0034613 IDA:MGI P cellular protein localization
GO:0018345 IEA:Ensembl P protein palmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC domain containing 18
Protein Entry
ZDH18_MOUSE
UniProt ID
Q5Y5T2
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity. {ECO:0000250}.
Function Has palmitoyltransferase activity towards HRAS and LCK. {ECO:0000269|PubMed:15603741}.
Similarity Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. {ECO:0000305}.
Similarity Contains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:15603741}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004732 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
114326532 RefSeq NP_001017968 380 palmitoyltransferase ZDHHC18

Identical Sequences to LMP004732 proteins

Reference Database Accession Length Protein Name
GI:114326532 GenBank AAI67166.1 380 Zinc finger, DHHC domain containing 18 [synthetic construct]
GI:114326532 SwissProt Q5Y5T2.4 380 RecName: Full=Palmitoyltransferase ZDHHC18; AltName: Full=Zinc finger DHHC domain-containing protein 18; Short=DHHC-18 [Mus musculus]

Related Sequences to LMP004732 proteins

Reference Database Accession Length Protein Name
GI:114326532 GenBank AAX73396.1 386 membrane-associated DHHC18 zinc finger protein [Rattus norvegicus]
GI:114326532 RefSeq NP_001034428.1 386 palmitoyltransferase ZDHHC18 [Rattus norvegicus]
GI:114326532 RefSeq XP_006539081.1 407 PREDICTED: palmitoyltransferase ZDHHC18 isoform X1 [Mus musculus]
GI:114326532 RefSeq XP_006539083.1 389 PREDICTED: palmitoyltransferase ZDHHC18 isoform X3 [Mus musculus]
GI:114326532 RefSeq XP_006539084.1 389 PREDICTED: palmitoyltransferase ZDHHC18 isoform X4 [Mus musculus]
GI:114326532 RefSeq XP_006539085.1 388 PREDICTED: palmitoyltransferase ZDHHC18 isoform X5 [Mus musculus]