Gene/Proteome Database (LMPD)

LMPD ID
LMP004765
Gene ID
8395
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Gene Symbol
PIP5K1B
Synonyms
MSS4; STM7
Alternate Names
phosphatidylinositol 4-phosphate 5-kinase type-1 beta; PIP5KIbeta; PIP5K1-beta; protein STM-7; ptdIns(4)P-5-kinase 1 beta; phosphatidylinositol 4-phosphate 5-kinase type I beta; phosphatidylinositol-4-phosphate 5-kinase type-1 beta; type I phosphatidylinositol 4-phosphate 5-kinase beta; type I phosphatidylinositol-4-phosphate 5-kinase beta
Chromosome
9
Map Location
9q13
EC Number
2.7.1.68

Proteins

phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 2
Refseq ID NP_003549
Protein GI 4505817
UniProt ID O14986
mRNA ID NM_003558
Length 540
RefSeq Status VALIDATED
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL
phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 3
Refseq ID NP_001265182
Protein GI 503776444
UniProt ID O14986
mRNA ID NM_001278253
Length 502
RefSeq Status VALIDATED
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVNEHYPHDRPTLYSNSK

Gene Information

Entrez Gene ID
8395
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Gene Symbol
PIP5K1B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0001931 IDA:UniProtKB C uropod
GO:0016308 NAS:UniProtKB F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0046854 NAS:GOC P phosphatidylinositol phosphorylation
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04144 Endocytosis
hsa04666 Fc gamma R-mediated phagocytosis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121025 Synthesis of PIPs at the plasma membrane
REACT_200668 WNT mediated activation of DVL

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Protein Entry
PI51B_HUMAN
UniProt ID
O14986
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O14986-1; Sequence=Displayed; Name=2; Synonyms=Isoform 1; IsoId=O14986-2; Sequence=VSP_016010, VSP_016011; Name=3; IsoId=O14986-3; Sequence=VSP_054771; Note=No experimental confirmation available.;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Caution There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.
Function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
Similarity Contains 1 PIPK domain. {ECO
Subcellular Location Endomembrane system . Note=Associated with membranes.
Subunit Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.
Tissue Specificity Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.

Identical and Related Proteins

Unique RefSeq proteins for LMP004765 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505817 RefSeq NP_003549 540 phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 2
503776444 RefSeq NP_001265182 502 phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 3

Identical Sequences to LMP004765 proteins

Reference Database Accession Length Protein Name
GI:4505817 DBBJ BAF85423.1 540 unnamed protein product [Homo sapiens]
GI:503776444 DBBJ BAG58479.1 502 unnamed protein product [Homo sapiens]
GI:4505817 GenBank EAW62465.1 540 phosphatidylinositol-4-phosphate 5-kinase, type I, beta, isoform CRA_a [Homo sapiens]
GI:4505817 GenBank AHD79548.1 540 Sequence 29192 from patent US 8586006
GI:4505817 RefSeq XP_005252318.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Homo sapiens]
GI:4505817 RefSeq XP_005252319.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [Homo sapiens]
GI:4505817 RefSeq XP_006717363.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3 [Homo sapiens]
GI:503776444 RefSeq XP_006717364.1 502 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [Homo sapiens]

Related Sequences to LMP004765 proteins

Reference Database Accession Length Protein Name
GI:503776444 DBBJ BAF85423.1 540 unnamed protein product [Homo sapiens]
GI:503776444 EMBL CAA63224.1 540 STM-7 [Homo sapiens]
GI:4505817 GenBank AAC51327.1 540 STM7 [Homo sapiens]
GI:4505817 GenBank AAQ02592.1 541 phosphatidylinositol-4-phosphate 5-kinase, type I, beta, partial [synthetic construct]
GI:503776444 GenBank AHD79548.1 540 Sequence 29192 from patent US 8586006
GI:4505817 RefSeq XP_003824804.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Pan paniscus]
GI:503776444 RefSeq XP_005252318.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Homo sapiens]
GI:503776444 RefSeq XP_005252319.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [Homo sapiens]
GI:503776444 RefSeq XP_006717363.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3 [Homo sapiens]
GI:4505817 RefSeq XP_008976662.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Pan paniscus]
GI:4505817 RefSeq XP_008976663.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Pan paniscus]
GI:4505817 RefSeq XP_008976664.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Pan paniscus]