Gene/Proteome Database (LMPD)

LMPD ID
LMP004768
Gene ID
239827
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class Z
Gene Symbol
Pigz
Synonyms
F630022B06Rik
Alternate Names
GPI mannosyltransferase 4; PIG-Z; GPI-MT-IV; GPI mannosyltransferase IV; phosphatidylinositol glycan, class Z; phosphatidylinositol-glycan biosynthesis class Z protein
Chromosome
16
Map Location
16 B2|16
EC Number
2.4.1.-

Proteins

GPI mannosyltransferase 4 precursor
Refseq ID NP_766410
Protein GI 255003686
UniProt ID Q8BTP0
mRNA ID NM_172822
Length 560
RefSeq Status VALIDATED
MMVAAQVIWGSFSLLRVLWCLLPQTGYIHPDEFFQSPEVMAEDILGVQATRPWEFYPSSSCRTVVFPLLTSGSTFWLLRLWEELGLWPGLVSGYMLLVGPRFLLTALSFALDWAVYDLAPLWGADRWNALCLLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSPGVVRSPTSKKPTPGPRWHRYLLGVILAAGFFNRPTFLAFALAPLSLWGIHRASELGGIRALIQEALVLLPGAALAAVLCVATDSWYFSSLSRSTGVFLTPANFLYYNLDPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQQLHACLRASPQTGLSRVRGARGLLSSSKSYLLLFYFTPLLLLSAFSHQEARFLIPLLVPLVLLCSPQTQPIPWKGTLVLFNILGALIFGCLHQGGLVPGLKYLEQIVHTPDLSGTTTHYTLLFTHTYMPPQHLLHLSGLGSPVEVVDMGGAEDRVLCQALNNFSRQPACQLAGEPWPCRLFVVTPGTNRHALEKCRFPLKNETLLFPHLTLEDPPALSSLLSGAWRKHLSLHVIELETPVVTKQPKAQP
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2311 peptide sequence: MMVAAQVIWGSFSLLRVLWC

Gene Information

Entrez Gene ID
239827
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class Z
Gene Symbol
Pigz
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000026 IEA:Ensembl F alpha-1,2-mannosyltransferase activity
GO:0006506 IEA:UniProtKB-UniPathway P GPI anchor biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
mmu00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR005599 GPI mannosyltransferase

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class Z
Protein Entry
PIGZ_MOUSE
UniProt ID
Q8BTP0
Species
Mouse

Comments

Comment Type Description
Function Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues (By similarity). {ECO:0000250}.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the glycosyltransferase 22 family. PIGZ subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004768 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
255003686 RefSeq NP_766410 560 GPI mannosyltransferase 4 precursor

Identical Sequences to LMP004768 proteins

Reference Database Accession Length Protein Name
GI:255003686 GenBank AAI17749.1 560 Phosphatidylinositol glycan anchor biosynthesis, class Z [Mus musculus]
GI:255003686 RefSeq XP_006522181.1 560 PREDICTED: GPI mannosyltransferase 4 isoform X1 [Mus musculus]
GI:255003686 RefSeq XP_006522182.1 560 PREDICTED: GPI mannosyltransferase 4 isoform X2 [Mus musculus]
GI:255003686 RefSeq XP_006522183.1 560 PREDICTED: GPI mannosyltransferase 4 isoform X3 [Mus musculus]
GI:255003686 SwissProt Q8BTP0.2 560 RecName: Full=GPI mannosyltransferase 4; AltName: Full=GPI mannosyltransferase IV; Short=GPI-MT-IV; AltName: Full=Phosphatidylinositol-glycan biosynthesis class Z protein; Short=PIG-Z [Mus musculus]

Related Sequences to LMP004768 proteins

Reference Database Accession Length Protein Name
GI:255003686 DBBJ BAC40783.1 560 unnamed protein product [Mus musculus]
GI:255003686 GenBank EDK97759.1 799 phosphatidylinositol glycan anchor biosynthesis, class Z [Mus musculus]
GI:255003686 RefSeq XP_008774975.1 558 PREDICTED: GPI mannosyltransferase 4 isoform X1 [Rattus norvegicus]
GI:255003686 RefSeq XP_008774976.1 558 PREDICTED: GPI mannosyltransferase 4 isoform X1 [Rattus norvegicus]
GI:255003686 RefSeq XP_008774977.1 558 PREDICTED: GPI mannosyltransferase 4 isoform X1 [Rattus norvegicus]
GI:255003686 RefSeq XP_008767003.1 558 PREDICTED: GPI mannosyltransferase 4 isoform X2 [Rattus norvegicus]