Gene/Proteome Database (LMPD)

LMPD ID
LMP004769
Gene ID
81849
Species
Homo sapiens (Human)
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Gene Symbol
ST6GALNAC5
Synonyms
SIAT7E; ST6GalNAcV
Alternate Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; SIAT7-E; ST6GalNAc V; GD1 alpha synthase; sialyltransferase 7E; GalNAc alpha-2,6-sialyltransferase V; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase V; ST6 neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase E; sialyltransferase 7 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E; sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E
Chromosome
1
Map Location
1p31.1
EC Number
2.4.99.-
Summary
ST6GALNAC5 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for ST6GALNAC5

Proteins

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Refseq ID NP_112227
Protein GI 13569938
UniProt ID Q9BVH7
mRNA ID NM_030965
Length 336
RefSeq Status PROVISIONAL
MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAAESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESLAINHPENKPVF

Gene Information

Entrez Gene ID
81849
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Gene Symbol
ST6GALNAC5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0001665 ISS:BHF-UCL F alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0008373 ISS:BHF-UCL F sialyltransferase activity
GO:0006688 ISS:BHF-UCL P glycosphingolipid biosynthetic process
GO:0009312 ISS:BHF-UCL P oligosaccharide biosynthetic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0097503 ISS:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00604 Glycosphingolipid biosynthesis - ganglio series
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_200874 Sialic acid metabolism
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Protein Entry
SIA7E_HUMAN
UniProt ID
Q9BVH7
Species
Human

Comments

Comment Type Description
Function Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By similarity).
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 29 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc V; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_634";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC5";

Identical and Related Proteins

Unique RefSeq proteins for LMP004769 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13569938 RefSeq NP_112227 336 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

Identical Sequences to LMP004769 proteins

Reference Database Accession Length Protein Name
GI:13569938 DBBJ BAI47233.1 336 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta- galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5, partial [synthetic construct]
GI:13569938 EMBL CAS91686.1 336 unnamed protein product [Homo sapiens]
GI:13569938 GenBank ABE14908.1 336 Sequence 2441 from patent US 6979557
GI:13569938 GenBank EAX06386.1 336 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Homo sapiens]
GI:13569938 GenBank AIC52445.1 336 ST6GALNAC5, partial [synthetic construct]
GI:13569938 RefSeq XP_004026053.1 336 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Gorilla gorilla gorilla]

Related Sequences to LMP004769 proteins

Reference Database Accession Length Protein Name
GI:13569938 EMBL CAG26704.1 335 alpha-2,6-sialyltransferase ST6GalNAc V, partial [Pan troglodytes]
GI:13569938 RefSeq NP_001032385.1 335 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Pan troglodytes]
GI:13569938 RefSeq XP_002810735.1 334 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Pongo abelii]
GI:13569938 RefSeq XP_003260270.1 334 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Nomascus leucogenys]
GI:13569938 RefSeq XP_003807839.1 335 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Pan paniscus]
GI:13569938 RefSeq XP_003892139.1 335 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 isoform X1 [Papio anubis]