Gene/Proteome Database (LMPD)

LMPD ID
LMP004783
Gene ID
20916
Species
Mus musculus (Mouse)
Gene Name
succinate-Coenzyme A ligase, ADP-forming, beta subunit
Gene Symbol
Sucla2
Synonyms
4930547K18Rik
Alternate Names
succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; SCS-betaA; succinyl-CoA synthetase beta-A chain; ATP-specific succinyl-CoA synthetase subunit beta
Chromosome
14
Map Location
14 D3|14
EC Number
6.2.1.5

Proteins

succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial precursor
Refseq ID NP_035636
Protein GI 46849708
UniProt ID Q9Z2I9
mRNA ID NM_011506
Length 463
RefSeq Status PROVISIONAL
MAASMFYGRQLAAAALRSHRPQTTLRAAAQVLGNSGLFNKHGLQVQQQQQRTLSLHEYLSMELLQEAGVSVPKGFVAKSSDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFTSGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSAQGGVNIEDVAAENPEAIVKEPIDIVEGIKKEQAVTLAQKMGFPSNIVDSAAENMIKLYNLFLKYDATMVEINPMVEDSDGKVLCMDAKINFDSNSAYRQKKIFDLQDWSQEDERDKEAANADINYIGLDGSIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVQQVTEAFKLITSDKKVQAILVNIFGGIMRCDVIAQGIVMAVKDLEIRIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAAKMVVKLSEIVTLAKEAHVDVKFQLPI
transit_peptide: 1..52 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9Z2I9.2) calculated_mol_wt: 5710 peptide sequence: MAASMFYGRQLAAAALRSHRPQTTLRAAAQVLGNSGLFNKHGLQVQQQQQRT mat_peptide: 53..463 product: Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9Z2I9.2) calculated_mol_wt: 44423 peptide sequence: LSLHEYLSMELLQEAGVSVPKGFVAKSSDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFTSGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSAQGGVNIEDVAAENPEAIVKEPIDIVEGIKKEQAVTLAQKMGFPSNIVDSAAENMIKLYNLFLKYDATMVEINPMVEDSDGKVLCMDAKINFDSNSAYRQKKIFDLQDWSQEDERDKEAANADINYIGLDGSIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVQQVTEAFKLITSDKKVQAILVNIFGGIMRCDVIAQGIVMAVKDLEIRIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAAKMVVKLSEIVTLAKEAHVDVKFQLPI

Gene Information

Entrez Gene ID
20916
Gene Name
succinate-Coenzyme A ligase, ADP-forming, beta subunit
Gene Symbol
Sucla2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0046872 IEA:InterPro F metal ion binding
GO:0004775 IEA:UniProtKB-EC F succinate-CoA ligase (ADP-forming) activity
GO:0004774 ISS:MGI F succinate-CoA ligase activity
GO:0006105 IEA:Ensembl P succinate metabolic process
GO:0006104 IEA:Ensembl P succinyl-CoA metabolic process
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00020 Citrate cycle (TCA cycle)

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR011761 ATP-grasp fold
IPR013815 ATP-grasp fold, subdomain 1
IPR013816 ATP-grasp fold, subdomain 2
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR005809 Succinyl-CoA synthetase, beta subunit
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
succinate-Coenzyme A ligase, ADP-forming, beta subunit
Protein Entry
SUCB1_MOUSE
UniProt ID
Q9Z2I9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Function Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA. {ECO:0000250}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Similarity Belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000305}.
Similarity Contains 1 ATP-grasp domain. {ECO:0000305}.
Subcellular Location Mitochondrion.
Subunit Heterodimer of an alpha and a beta subunit. Interacts with ALAS2 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004783 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46849708 RefSeq NP_035636 463 succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial precursor

Identical Sequences to LMP004783 proteins

Reference Database Accession Length Protein Name
GI:46849708 DBBJ BAE35942.1 463 unnamed protein product [Mus musculus]
GI:46849708 DBBJ BAE21343.1 463 unnamed protein product [Mus musculus]
GI:46849708 DBBJ BAE35647.1 463 unnamed protein product [Mus musculus]
GI:46849708 GenBank AAH56353.1 463 Succinate-Coenzyme A ligase, ADP-forming, beta subunit [Mus musculus]
GI:46849708 GenBank AAH57605.1 463 Succinate-Coenzyme A ligase, ADP-forming, beta subunit [Mus musculus]
GI:46849708 SwissProt Q9Z2I9.2 463 RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; AltName: Full=ATP-specific succinyl-CoA synthetase subunit beta; AltName: Full=Succinyl-CoA synthetase beta-A chain; Short=SCS-betaA; Flags: Precursor [Mus musculus]

Related Sequences to LMP004783 proteins

Reference Database Accession Length Protein Name
GI:46849708 DBBJ BAE31798.1 470 unnamed protein product, partial [Mus musculus]
GI:46849708 DBBJ BAE29687.1 470 unnamed protein product, partial [Mus musculus]
GI:46849708 RefSeq NP_001101857.2 465 succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [Rattus norvegicus]
GI:46849708 RefSeq XP_005355668.1 463 PREDICTED: succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [Microtus ochrogaster]
GI:46849708 RefSeq XP_007647229.1 463 PREDICTED: succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1 [Cricetulus griseus]
GI:46849708 RefSeq XP_007618184.1 463 PREDICTED: succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X3 [Cricetulus griseus]