Gene/Proteome Database (LMPD)

LMPD ID
LMP004802
Gene ID
75669
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Gene Symbol
Pik3r4
Synonyms
2210010O15Rik; C730038E05Rik; C85833; D9Ertd418e
Alternate Names
phosphoinositide 3-kinase regulatory subunit 4; PI3-kinase regulatory subunit 4
Chromosome
9
Map Location
9 F1|9 56.79 cM
EC Number
2.7.11.1

Proteins

phosphoinositide 3-kinase regulatory subunit 4
Refseq ID NP_001074778
Protein GI 124486789
UniProt ID Q8VD65
mRNA ID NM_001081309
Length 1358
RefSeq Status PROVISIONAL
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRARGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDRSIRDLVTQMINREPEKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGESRASGLVVLVSVITSCLQTLKSCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKTLNMENEPDNEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVKQTLMESGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVAHQISTADVYCKLMPYLDPYITQPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHLHMRQKKRNGSLLDCPPPEDPTIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNRAKANAVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDEKRARKHVKQDSNVNEEWKSMFGSLEPPNIPQALPKTSDHEVVQPGKPPRSESSAGICVPLSTSPQVSEAAHIPSKKPVIPVVSSTVLPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHLLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGAMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRLTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLVSPERSYVVAGSTGSPSVSYYKKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDIATFQTTQGFIVTASRDGIVKVWK

Gene Information

Entrez Gene ID
75669
Gene Name
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Gene Symbol
Pik3r4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005930 IDA:UniProtKB C axoneme
GO:0005770 ISS:UniProtKB C late endosome
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
mmu04140 Regulation of autophagy

REACTOME Pathway Links

REACTOME Pathway ID Description
5894013 Synthesis of PIPs at the early endosome membrane
5894010 Synthesis of PIPs at the late endosome membrane

Domain Information

InterPro Annotations

Accession Description
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR019775 WD40 repeat, conserved site
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Protein Entry
PI3R4_MOUSE
UniProt ID
Q8VD65
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Function Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway (By similarity). {ECO:0000250}.
Ptm Myristoylated. {ECO:0000250}.
Ptm Probably autophosphorylated. {ECO:0000250}.
Similarity Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 4 HEAT repeats. {ECO:0000255|PROSITE- ProRule:PRU00103}.
Similarity Contains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular Location Late endosome {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000269|PubMed:24089209}.
Subunit Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with the phosphatidylinositol 3-kinase type 3 (PIK3C3) (By similarity). Forms a complex with BECN1, PIK3C3 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive (By similarity). Part of a complex composed by PIK3C3 and PIK3CB. Interacts with RAB7A in the presence of PIK3C3/VPS34 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004802 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124486789 RefSeq NP_001074778 1358 phosphoinositide 3-kinase regulatory subunit 4

Identical Sequences to LMP004802 proteins

Reference Database Accession Length Protein Name
GI:124486789 SwissProt Q8VD65.3 1358 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 4; Short=PI3-kinase regulatory subunit 4 [Mus musculus]

Related Sequences to LMP004802 proteins

Reference Database Accession Length Protein Name
GI:124486789 GenBank AAI57948.1 1358 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150 [Mus musculus]
GI:124486789 GenBank AAI68984.1 1358 Pik3r4 protein [Rattus norvegicus]
GI:124486789 RefSeq XP_006243862.1 1358 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [Rattus norvegicus]
GI:124486789 RefSeq XP_006243863.1 1358 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [Rattus norvegicus]
GI:124486789 RefSeq XP_006983681.1 1358 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 [Peromyscus maniculatus bairdii]
GI:124486789 SwissProt P0C0R5.2 1358 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 4; Short=PI3-kinase regulatory subunit 4 [Rattus norvegicus]